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AFF2 Antibody

  • 中文名稱：
    AFF2兔多克隆抗體
  • 貨號：
    CSB-PA001413LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate
      All lanes: AFF2 antibody at 5µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 145, 141, 48, 144, 106 kDa
      Observed band size: 145 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AFF2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AFF2
  • 別名：
    AF4/FMR2 family member 2 antibody; AF4/FMR2 family, member 2 antibody; AFF2 antibody; AFF2_HUMAN antibody; FMR2 antibody; FMR2P antibody; Fragile X E mental retardation syndrome protein antibody; fragile X mental retardation 2 antibody; Fragile X mental retardation 2 protein antibody; fragile X mental retardation gene associated with FRAXE antibody; FRAXE antibody; mild or borderline mental retardation antibody; MRX2 antibody; OTTHUMP00000024204 antibody; OX19 antibody; Protein FMR-2 antibody; Protein Ox19 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human AF4/FMR2 family member 2 protein (575-705AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，AFF2 Antibody (CSB-PA001413LA01HU)，的標記方式是Non-conjugated。對于AFF2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA001413LB01HU AFF2 Antibody, HRP conjugated ELISA
    FITC CSB-PA001413LC01HU AFF2 Antibody, FITC conjugated
    Biotin CSB-PA001413LD01HU AFF2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure.
  • 基因功能參考文獻：
    1. Partial AFF2 microduplication in a patient with auditory processing disorder, emotional impairment and macrosomia. PMID: 25256661
    2. FMR2 is an upstream regulator of FOS and JUN, and further link deregulation of the immediate early response genes to the pathology of ID- and FRAXE-associated ID in particular. PMID: 23562910
    3. 2.5% of males Autism spectrum disorder patients had missense mutations in AFF2 at highly conserved evolutionary sites. PMID: 22773736
    4. A report of novel deletions involving AFF2 provide evidence for a new mutational spectrum, microdeletions, that are responsible for Fragile X E in a small subset of patients. PMID: 22065534
    5. overexpression of AFF2/3/4 interferes with the organization and/or biogenesis of nuclear speckles. PMID: 21330300

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  • 相關疾病：
    Mental retardation, X-linked, associated with fragile site FRAXE (MRFRAXE)
  • 亞細胞定位：
    Nucleus speckle. Note=When splicing is inhibited, accumulates in enlarged speckles.
  • 蛋白家族：
    AF4 family
  • 組織特異性：
    Brain (most abundant in hippocampus and amygdala), placenta and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3776

    OMIM: 300806

    KEGG: hsa:2334

    STRING: 9606.ENSP00000359489

    UniGene: Hs.496911



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