在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AES Antibody

  • 中文名稱:
    AES兔多克隆抗體
  • 貨號:
    CSB-PA973928
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA973928(AES Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA973928(AES Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AES
  • 別名:
    Aes 1 antibody; Aes 2 antibody; aes antibody; AES_HUMAN antibody; Aes1 antibody; Aes2 antibody; Amino enhancer of split antibody; Amino terminal enhancer of split antibody; Amino-terminal enhancer of split antibody; Esp 1 antibody; Esp1 antibody; Gp130 associated protein GAM antibody; Gp130-associated protein GAM antibody; GRG 5 antibody; GRG antibody; GRG protein antibody; Grg-5 antibody; GRG5 antibody; Groucho-related protein 5 antibody; Protein ESP 1 antibody; Protein ESP1 antibody; Protein GRG antibody; TLE 5 antibody; TLE5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human AES
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
  • 基因功能參考文獻:
    1. Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa) by regulating both androgen receptor (AR) and Notch signaling pathway. PMID: 28178391
    2. results indicate that Aes may belong to a novel family of metastasis suppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally PMID: 27561171
    3. heat shock cognate 70 (HSC70) is an essential component of Aes foci in colorectal cancer cells. PMID: 26229111
    4. AES is a transcriptional repressor for HNF-1-alpha in pancreatic beta-cell. PMID: 26549228
    5. AES binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone deficiency. PMID: 23732115
    6. alteration of the malignant behavior of cancer cells by AES is related to RND3 regulation. PMID: 23546594
    7. In the presence of NUP98-HOXA9, AES caused an increase in long-term proliferation of primary human CD34+ cells with a marked increase in the numbers of primitive cells. PMID: 21937451
    8. Elevated levels of AES mRNA and protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens. PMID: 21245488
    9. LRP6-ICD interacts with AES exclusively in the nucleus and represses AES mediated TCF/LEF-1 reporter transcription. PMID: 20676368
    10. Data report that the negative regulatory domain of AES inhibits AES dimerization and AES-mediated inhibition of AR-driven transcription through an interaction with the inhibitory domain. PMID: 20163360
    11. Results identify Bit1, a mitochondrial protein released into the cytoplasm during apoptosis that forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein. PMID: 15006356
    12. amino enhancer of split has apoptotic activity in neurons and suggest that neuroprotection by histone deacetylase-related protein is mediated by the inhibition of this activity through direct interaction. PMID: 18438919

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    WD repeat Groucho/TLE family
  • 組織特異性:
    Found predominantly in muscle, heart and Placenta. In fetal tissues, abundantly expressed in the heart, lung, kidney, brain and liver.
  • 數據庫鏈接:

    HGNC: 307

    OMIM: 600188

    KEGG: hsa:166

    STRING: 9606.ENSP00000221561

    UniGene: Hs.515053



主站蜘蛛池模板: 国产福利视频在线观看| 人妻精油按摩bd高清中文字幕 | 国产日韩另类综合11页| 国产桃色无码视频在线观看| 午夜好爽好舒服免费视频| 日本亚洲国产一区二区三区| 色欲天天天天天综合网| 中日韩产精品1卡二卡三卡| 亚洲人成色77777在线观看| 国产又黄又硬又粗| 国产永久免费观看视频| 久久综合88熟人妻| 国产成人无码精品久久久性色| 98久久人妻少妇激情啪啪| 亚洲中文有码字幕日本| 免费午夜男女高清视频| 苍井空一区二区波多野结衣av| 国产成人久久精品一区二区三区| 中文字幕乱码一区av久久不卡| 永久免费观看黄网视频| 最新 国产 精品 精品 视频| 亚洲欧美成aⅴ人在线观看| 日日摸日日碰人妻无码老牲| 日本理伦片午夜理伦片| 波多野结衣乱码中文字幕| 午夜嘿嘿嘿在线观看| 欧美日韩精品一区二区在线观看| 亚洲日韩aⅴ在线视频| 国产精品国产三级国产a| 十八禁无码精品a∨在线观看| 国产在线精品视频二区| 区二区三区国产精华液区别大吗| 377p欧洲日本亚洲大胆| 少妇人妻邻居| 亚洲爆乳无码专区www| 国产交换配乱婬视频偷网站| 九九视频免费精品视频| 色一情一乱一伦| 免费观看的av在线播放| 国产人成高清在线视频99最全资源| 日韩人妻ol丝袜av一二区|