在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AEBP1 Antibody

  • 中文名稱:
    AEBP1兔多克隆抗體
  • 貨號:
    CSB-PA225304
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA225304(AEBP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA225304(AEBP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AEBP1
  • 別名:
    AEBP1 antibody; ACLP antibody; Adipocyte enhancer-binding protein 1 antibody; AE-binding protein 1 antibody; Aortic carboxypeptidase-like protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human AEBP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix.; May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor.
  • 基因功能參考文獻:
    1. These studies support the conclusion that bi-allelic pathogenic variants in AEBP1 are the cause of this autosomal-recessive Ehlers-Danlos Syndrome subtype. PMID: 29606302
    2. Studies identify ACLP as a stromal derived mediator of adipose progenitor differentiation that may limit adipocyte expansion during white adipose tissue fibrosis. PMID: 29799877
    3. AEBP1 protein is expressed in the pyramidal neurons of human central nervous system and increased in neurons and glial cells of hippocampi and parahippocampal cortices, correlating with the progression of Alzheimer's disease. PMID: 27997051
    4. ACLP stimulates the fibroblast-to-myofibroblast transition by promoting SMA expression via TGFbeta signaling and promoting collagen expression through a TGFbeta receptor-independent pathway. PMID: 24344132
    5. There is no statistically significant differences in the frequency of variants in AEBP1 among the gastroschisis case group compared to a Caucasian control group. PMID: 22821744
    6. Most ACLP knockout mice die perinatally due to abdominal issues. PMID: 11438679
    7. Both cellular proliferation and survival were affected in AEBP1-silenced U87MG and U138MG cell lines and a significant percentage of these cells were directed towards apoptosis. PMID: 22723309
    8. This review focuses on the recently reported regulatory functions that adipocyte enhancer-binding protein 1 (AEBP1) exerts on PPARgamma1 and LXRalpha transcriptional activity in the context of macrophage cholesterol homeostasis and inflammation. PMID: 20419060
    9. Transgenic overexpression of AEBP1 during adipogenesis coupled with a high-fat diet results in massive obesity in female transgenic mice via adipocyte hyperplasia. PMID: 16307171
    10. ACLP and its discoidin-like domain may be novel targets for anti-myofibroblast-based therapies for the treatment of pulmonary fibrosis. PMID: 19179605

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族:
    Peptidase M14 family
  • 組織特異性:
    Expressed in osteoblast and visceral fat.
  • 數據庫鏈接:

    HGNC: 303

    OMIM: 602981

    KEGG: hsa:165

    STRING: 9606.ENSP00000223357

    UniGene: Hs.439463



主站蜘蛛池模板: 国产亚洲精品岁国产微拍精品| 午夜福利日本一区二区无码| 中国凸偷窥xxxx自由视频| 99久久国产露脸精品竹菊传媒| 开心五月激情综合婷婷色| 欧美内射深喉中文字幕| 亚洲中文字幕久久无码| 四虎国产精品永久免费网址 | 国产初高中生粉嫩无套第一次| 久久精品网站免费观看| 久久超碰极品视觉盛宴| 内射女校花一区二区三区| 久久99精品久久只有精品| 狠狠色噜噜狠狠狠狠av| 国产精品多p对白交换绿帽| 国产精品国产三级国产av麻豆| 国产成人精品免费视频大全软件| 人妻熟女一区二区三区app下载| 成人国产片女人爽到高潮| 亚洲精品一品区二品区三品区| 国产xxxx视频在线| 国产欧美日韩综合在线成| 欧美一区二区三区久久综| 久久精品国产99精品国产2021| 国产熟妇搡bbbb搡bbbb搡| 在线观看国产成人av片| 国语对白刺激精品视频| 色综合久久网| 国产精品sp调教打屁股| 国产九九99久久99大香伊| 亚洲中文字幕a∨在线| 小鲜肉自慰网站| 久久精品国产99国产精品导航| 国产成人精品久久一区二区三区| 欧美激烈精交gif动态图| 亚洲国产福利一区二区三区| 97久久精品亚洲中文字幕无码| 免费人成视频在线观看视频| 久久国产精品日本波多野结衣| 少妇人妻大乳在线视频 | 香港三级韩国三级日本三级 |