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  4. ADHFE1 Antibody

ADHFE1 Antibody

  • 中文名稱：
    ADHFE1兔多克隆抗體
  • 貨號：
    CSB-PA001363GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ADHFE1
  • 別名：
    ADH8 antibody; ADHFE 1 antibody; ADHFe1 antibody; Alcohol dehydrogenase iron-containing protein 1 antibody; Alcohol dehydrogenase; iron containing; 1 antibody; Fe containing alcohol dehydrogenase antibody; Fe-containing alcohol dehydrogenase antibody; HOT antibody; HOT_HUMAN antibody; Hydroxyacid oxoacid transhydrogenase; mitochondrial antibody; Hydroxyacid-oxoacid transhydrogenase antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ADHFE1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities.
  • 基因功能參考文獻：
    1. These results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-mediated down expression of ADHFE1 and proliferation of CRC cells. PMID: 24886599
    2. ADHFE1 has an important role of differentiation in CRC, as well as normal colorectal mucosa and embryonic developmental processes. PMID: 23517143
    3. cloned and characterized an iron-activated alcohol dehydrogenase gene, Fe-containing alcohol dehydrogenase 1 (ADHFe1) PMID: 12592711
    4. show that the ADHFe1 gene is related to bacterial GHB dehydrogenases and has a conserved NAD-binding site PMID: 19013439
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    Iron-containing alcohol dehydrogenase family, Hydroxyacid-oxoacid transhydrogenase subfamily
  • 組織特異性：
    Only expressed in adult liver.
  • 數據庫鏈接：

    HGNC: 16354

    OMIM: 611083

    KEGG: hsa:137872

    STRING: 9606.ENSP00000379865

    UniGene: Hs.720023



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