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  4. ADD3 Antibody

ADD3 Antibody

  • 中文名稱：
    ADD3兔多克隆抗體
  • 貨號：
    CSB-PA000827
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using Adducin γ Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using Adducin γ Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ADD3
  • 別名：
    ADD3 antibody; ADDG_HUMAN antibody; ADDL antibody; Adducin 3 (gamma) antibody; Adducin 3 antibody; Adducin; gamma antibody; Adducin-like antibody; Adducin-like protein 70 antibody; Gamma-adducin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Adducin γ.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin.
  • 基因功能參考文獻：
    1. ADD3 and ADD3-AS1 variants increased susceptibility to BA, suggesting that these genes may play an additive role in the pathogenesis of the disease. PMID: 29508064
    2. Data indicate lysine acetyltransferase 2B (KAT2B) as a susceptibility gene for kidney and heart disease in adducin 3 (gamma) protein (ADD3)-associated disorders. PMID: 29768408
    3. MiR-145-5p was confirmed to target ADD3 by luciferase reporter assay. The downregulation of miR-145 may contribute to liver fibrosis in Biliary atresia by upregulating the expression of ADD3. PMID: 28902846
    4. ADD3 gene deletion is associated with acute lymphoblastic leukemia. PMID: 28033648
    5. ADD3 gene plays an important role in biliary atresia pathogenesis. PMID: 25285724
    6. Common genetic variants in 10q24.2 can alter biliary atresia risk by regulating ADD3 expression levels in the liver, and may exert an effect on disease epidemiology and on the general population. PMID: 23872602
    7. High expression of ADD3 is associated with glioma. PMID: 23814265
    8. ADD3 gene may be functionally relevant for the development of biliary atresia PMID: 24104524
    9. Homozygous p.G367D mutation in ADD3 causes spastic diplegic/quadriplegic cerebral palsy and intellectual disability. PMID: 23836506
    10. gamma-adducin may influence blood pressure homeostasis by modulating renal NaCl transport. PMID: 21164023
    11. The early expression of ADD3 suggests that it may have a role in erythroblasts but is replaced by ADD2 in later stages of erythropoiesis. PMID: 15963851
    12. Left ventricular diastolic relaxation is modulated by genetic variation in ADD3. PMID: 18475162
    13. In ADD1 GlyGly homozygotes, the properties of the brachial artery are related to the ADD3 (A386G) polymorphism, but the underlying mechanism needs further clarification. PMID: 18787518

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  • 相關疾?。?/div>
    Cerebral palsy, spastic quadriplegic 3 (CPSQ3)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Aldolase class II family, Adducin subfamily
  • 組織特異性：
    Isoform 1 is ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 245

    OMIM: 601568

    KEGG: hsa:120

    STRING: 9606.ENSP00000348381

    UniGene: Hs.501012



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