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  4. ADAMTS17 Antibody

ADAMTS17 Antibody

  • 中文名稱：
    ADAMTS17兔多克隆抗體
  • 貨號：
    CSB-PA007786
  • 規(guī)格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ADAMTS17
  • 別名：
    A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif; 17 antibody; ADAM metallopeptidase with thrombospondin type 1 motif; 17 antibody; ADAM-TS 17 antibody; ADAM-TS17 antibody; ADAMTS 17 antibody; ADAMTS-17 antibody; ADAMTS17 antibody; ATS17_HUMAN antibody; EC 3.4.24. antibody; FLJ16363 antibody; FLJ32769 antibody; OTTHUMP00000194818 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ADAMTS-17.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 基因功能參考文獻：
    1. Secretion of ADAMTS17 requires O-fucosylation. ADAMTS17 binds fibrillin-2 but not fibrillin-1 and does not cleave either. ADAMTS17 regulates fibrillin isoform composition of microfibrils in the eye. PMID: 28176809
    2. higher Adamts17 expression is found in several human cancer cell subtypes, especially in breast ductal carcinoma and there is an inverse correlation between higher Adamts17 expression and patients' survival. PMID: 24906090
    3. The mutation in the Weill-Marchesani syndrome (WMS)- gene ADAMTS17 also causes WMS in an Indian family. PMID: 24940034
    4. A mutation in WMS-like gene ADAMTS17 also causes WMS. PMID: 24940034
    5. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
    6. Recessive ADAMTS17 mutations are a recurrent cause of isolated spherophakia with short stature. PMID: 22486325
    7. ADAMTS17 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
    8. Homozygous mutation in ADAMTS17 causes lenticular myopia, ectopia lentis, glaucoma, spheropakia, and short stature. PMID: 19836009

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  • 相關疾?。?/div>
    Weill-Marchesani-like syndrome (WMSL)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 組織特異性：
    Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17109

    OMIM: 607511

    KEGG: hsa:170691

    STRING: 9606.ENSP00000268070

    UniGene: Hs.513200



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