在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADAM28 Antibody

  • 中文名稱:
    ADAM28兔多克隆抗體
  • 貨號:
    CSB-PA892455ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: ADAM28 antibody IgG at 5.6μg/ml + PC-3 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 88, 62 kDa
      Observed band size: 88 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA892455ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ADAM28 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ADAM28
  • 別名:
    ADAM28 antibody; ADAM23 antibody; MDCLDisintegrin and metalloproteinase domain-containing protein 28 antibody; ADAM 28 antibody; EC 3.4.24.- antibody; Epididymal metalloproteinase-like antibody; disintegrin-like antibody; and cysteine-rich protein II antibody; eMDC II antibody; Metalloproteinase-like antibody; disintegrin-like antibody; and cysteine-rich protein L antibody; MDC-L antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 28 protein (199-440AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
  • 基因功能參考文獻:
    1. Within placental villi, ADAM28 mRNA levels were highest in HLA-G(+) column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G(+) trophoblasts within distal anchoring columns and decidual tissue. PMID: 28623976
    2. There is a relationship between the serum level of ADAM28 and the degree of the colonic cancer clinical stage. PMID: 29254295
    3. miR-552 is an oncomir able to promote CRC metastasis in part through a mechanism of targeting ADAM28. PMID: 27661126
    4. The data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells. PMID: 26918856
    5. ADAM28 is overexpressed in primary human prostate tumor biopsies, and it promotes human prostate cancer cell proliferation and migration. PMID: 27749584
    6. The results of this study suggest that these proteins play important roles in pulmonary inflammatory reactions elicited against etiological viral agents. PMID: 25453333
    7. Src is an inducer of ADAM28 gene expression through the MEK/extracellular signal-regulated kinase and PI3K/mammalian target of rapamycin pathways. PMID: 24007880
    8. IL-1beta-induced MMP-13 expression and changes in cell proliferation and apoptosis in alpha7(+)hSMSC-OB cells are regulated by ADAM-28. PMID: 24613731
    9. Sequence analysis of ADAM28 genes did not reveal any putative mutations for hyperostosis cranialis interna to chromosome 8p21 PMID: 23640157
    10. The change of ADAM28 and IGFBP-3 gene expression is present in the normal tissue in overweight/obese patients with colorectal cancer only, and the observed variability of ADAM28 and IGFBP-3 expression may be an initial process of cancer proliferation PMID: 23527725
    11. High ADAM28 expression is associated with B-Cell Chronic Lymphocytic Leukemia. PMID: 23643150
    12. Human ADAM28 expression levels were positively correlated with parameters of the metabolic syndrome. PMID: 23010875
    13. ADAM28 cleaves and inactivates proapoptotic VWF in carcinoma cells and enhances lung metastasis probably by promoting carcinoma cell survival within the blood vessels. PMID: 22636800
    14. Study shows using proteomics that ADAM28 may be used as a possible biomarker of bladder cancer. PMID: 21913264
    15. ADAM28 showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer. PMID: 21782798
    16. ADAM28 might actively participate in manipulating the proliferation, differentiation, and apoptosis of human dental pulp stem cells (HDPSCs). PMID: 21329817
    17. It plays a role in cancer cell proliferation, invasion and metastasis. (review) PMID: 21077327
    18. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF(165)-induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF(165) complex. PMID: 20971063
    19. High ADAM28 in serum is associated with non-small-cell lung cancers. PMID: 20112342
    20. Upregulation of ADAM28 is associated with asbestos-related lung adenocarcinomas. PMID: 20544843
    21. was able to effectively manipulate the proliferation, apoptosis, and differentiation of human periodontal ligament stem cells PMID: 20450360
    22. overexpression of A disintegrin and metalloproteinase 28 was increased according to its histologic grade in conventional chondrosarcoma and could be one of the helpful tools in distinguishing between low-grade chondrosarcoma and enchondroma. PMID: 19896699
    23. ADAM8, ADAM15, and ADAM28, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE receptor. PMID: 12777399
    24. data demonstrate for the first time that ADAM28 is overexpressed and activated in human non-small cell lung carcinomas, and suggest the possibility that ADAM28 plays a role in cell proliferation and progression of the human lung carcinomas PMID: 16052521
    25. ADAM28 is overexpressed in an activated form in breast carcinoma cells and suggest ADAM28 is involved in cell proliferation through enhanced bioavailability of IGF-I released from the IGF-I/IGFBP-3 complex by IGFBP-3 cleavage in breast carcinomas. PMID: 17047053
    26. ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1 PMID: 17597069
    27. Report essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells. PMID: 18690470
    28. These results indicate that ADAM28 participates in proteoglycan degradation. PMID: 19527685

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed predominantly in secondary lymphoid tissues, such as lymph node, spleen, small intestine, stomach, colon, appendix and trachea. The lymphocyte population is responsible for expression of this protein in these tissues. Isoform 2 is expressed pref
  • 數據庫鏈接:

    HGNC: 206

    OMIM: 606188

    KEGG: hsa:10863

    STRING: 9606.ENSP00000265769

    UniGene: Hs.174030



主站蜘蛛池模板: 国产精品无码av在线播放| 久热这里只有精品99| 最新精品国偷自产在线老年人| 少妇被粗大猛进进出出| 精品国产18久久久久久| 欧美日韩免费专区在线| 欧产日产国产精品| 国精一二二产品无人区免费应用| 亚洲色偷精品一区二区三区| 欧美亚洲偷图色综合| 中文字幕久久精品一区二区三区| 天堂无码人妻精品一区二区三区| 国产一区二区精品丝袜| 人牛交vide欧美xxxx| 成人夜色视频网站在线观看| 亚洲精品久久久久国产| 无码av中文一区二区三区桃花岛| 极品人妻被黑人中出种子| 成人无码午夜在线观看| 国产人妻人伦精品| 亚洲精品久久久久久无码色欲四季| 成在人线av无码免费漫画| 人人妻人人爽人人爽| 免费的黄网站在线观看| 又色又爽又高潮免费观看| 亚洲国产精品无码中文字| 国内精品久久久久久久小说| 成熟丰满熟妇高潮xxxxx视频| 3d动漫精品啪啪一区二区中| 男人女人做爽爽18禁网站| 中文区中文字幕免费看| 一本一道vs无码中文字幕| 无码精品人妻一区二区三区98| 国产精品揄拍100视频| 久久aⅴ无码av高潮av喷吹| 亚洲欧美日韩中文二区| 开心婷婷五月激情综合社区| 人妻 日韩精品 中文字幕| 国产精品久久久久久爽爽爽床戏| 色噜噜狠狠色综合av| 看曰本女人大战黑人视频|