在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ADAM19 Antibody

  • 中文名稱:
    ADAM19兔多克隆抗體
  • 貨號:
    CSB-PA880929ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA880929ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA880929ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ADAM19 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ADAM19
  • 別名:
    ADAM19 antibody; MLTNB antibody; FKSG34Disintegrin and metalloproteinase domain-containing protein 19 antibody; ADAM 19 antibody; EC 3.4.24.- antibody; Meltrin-beta antibody; Metalloprotease and disintegrin dendritic antigen marker antibody; MADDAM antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Disintegrin and metalloproteinase domain-containing protein 19 protein (203-460AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone.
  • 基因功能參考文獻:
    1. 3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease. PMID: 27078193
    2. ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer. PMID: 26912236
    3. these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells PMID: 26823772
    4. miR-30c inhibited colon cancer cells via targeting ADAM19. PMID: 25799050
    5. four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease. PMID: 25114068
    6. ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function. PMID: 24951661
    7. MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19 PMID: 25475731
    8. ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls. PMID: 23429442
    9. Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments. PMID: 21270819
    10. Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma. PMID: 21239057
    11. These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2. PMID: 20460109
    12. ADAM19 correlates with the progress and prognosis of endometrial carcinoma. PMID: 18458692
    13. ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation. PMID: 19727588
    14. activation by furin via one of two consecutive recognition sites PMID: 12006600
    15. investigation of proteolytic activity PMID: 12393862
    16. yeast two-hybrid screen performed in fetal brain cDNA library isolated four proteins that interact with the cytoplasmic tail of ADAM19 PMID: 12463424
    17. A new autolytic processing site at Lys543-Val544 was identified in soluble mutants of ADAM19 when these cysteine residues were individually mutated to serine residues. PMID: 15242783
    18. ChIP assays demonstrated high levels of acetylated histone H3 in the promoter region of the MADDAM gene in TSA-treated THP-1 cells/dendritic cells compared to macrophages, indicating an important role of histone acetylation in regulating the MADDAM gene. PMID: 15896713
    19. ADAM19 may have a modulatory role in the dysfunctional renal allograft state PMID: 16827870
    20. results suggest that ADAM19 has a constitutive alpha-secretase activity for amyloid precursor protein PMID: 17112471
    21. we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer. PMID: 18714391

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in many normal organ tissues and several cancer cell lines.
  • 數據庫鏈接:

    HGNC: 197

    OMIM: 603640

    KEGG: hsa:8728

    STRING: 9606.ENSP00000257527

    UniGene: Hs.483944



主站蜘蛛池模板: 中文字幕精品久久久久人妻红杏 | 国产精品久久久久久影视 | 午夜精品久久久久9999| 亚洲高清国产拍精品26u| 少妇人妻丰满做爰xxx| 乱人伦人妻中文字幕无码| 熟妇人妻无码中文字幕老熟妇| 久久香蕉国产线看观看亚洲小说 | 亚洲中文字幕无码日韩精品| 超碰97人人射妻| 怡春院国产精品视频| av网站的免费观看| 97久久人人超碰超碰窝窝| 成人毛片无码一区二区三区| 国产亚洲精品久久久久秋霞不卡| 亚洲精品久久国产精品| 亚洲风影视传媒有限公司辽宁| 久久婷婷五月综合97色一本一本| 狠狠亚洲婷婷综合色香五月排名| 日韩加勒比一本无码精品| 亚洲人亚洲人成电影网站色| 西西人体www大胆高清视频| 精品视频一区二区三三区四区| 精品国内自产拍在线观看| 把女邻居弄到潮喷的性经历| 久久精品黄aa片一区二区三区 | 99精品久久久久久久婷婷| 中文字幕丝袜精品久久| 无遮挡很爽很污很黄的网站| 无码成人一区二区三区| 国产熟妇午夜精品aaa| 久久久久久亚洲综合影院| 国产精品久久久久久亚洲色| 人妻少妇精品无码专区二区| 国产毛片毛多水多的特级毛片| 欧美激欧美啪啪片| 国精产品一二三区精华液| 国产一区二区三区免费高清在线播放| 岛国无码av不卡一区二区| 国产偷人爽久久久久久老妇app| 色婷婷久久综合中文久久一本|