在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACVR2A Antibody

  • 中文名稱:
    ACVR2A兔多克隆抗體
  • 貨號:
    CSB-PA070256
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ACVR2A; ACVR2; Activin receptor type-2A; Activin receptor type IIA; ACTR-IIA; ACTRIIA
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the N-terminal region of Human ACTR-IIA.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
  • 基因功能參考文獻:
    1. Altered decidual ACVR2A expression impairs the ability of stromal cells to properly decidualise and regulate trophoblast function at the maternalfetal interface, which may result in abnormal placentation that can lead to poor pregnancy outcomes such as pre-eclampsia. PMID: 29203340
    2. Results showed no association between genotypes and preeclampsia for polymorphisms rs5186, rs4606 in 3'UTR of genes ACVR2A, AGTR1 and RGS2 in women with preeclampsia PMID: 29593124
    3. TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.( PMID: 27696331
    4. This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality. PMID: 27832070
    5. Data suggest ALK1 and ACVR2A/ACVR2B, acting as BMP9 co-receptors, rearrange pro-domains of BMP9--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling. PMID: 26677222
    6. Activin A inhibited signaling by BMP-6 and BMP-9 by competing for type 2 receptors ACVR2A and ACVR2B. PMID: 26047946
    7. Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (as seen in pre-eclampsia). PMID: 25659497
    8. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors. PMID: 26086422
    9. The gene ACVR2A was associated with the more severe early onset preeclampsia. PMID: 25499008
    10. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies. PMID: 23633461
    11. ACVR2A was identified as a subnetwork component in functional association network analysis. PMID: 23263486
    12. ACVR2A showed statistically significant differential dose-expression relationship. PMID: 22848350
    13. ACVR2A interaction with Nodal and ADMP regulates head development from the 'organizer', a restricted group of cells in the embryo. PMID: 22949641
    14. This is the first report on the function of miR-195 in human placental trophoblast cells which reveals an invasion-promoting effect of the small RNA via repressing ActRIIA. PMID: 22723898
    15. Activin type IIA receptors are clearly demonstrable throughout the adult human hypothalamus and basal forebrain. PMID: 22296042
    16. Exonic selectivity for frameshift mutation within ACVR2 is specifically controlled by individual nucleotides flanking each coding ACVR2 microsatellite. PMID: 22001236
    17. Mutation in activin type II receptor is associated with colorectal cancer. PMID: 20197483
    18. crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor PMID: 12667445
    19. Activin type II receptor gene (ACTRII) is probably involved in both non-microsattelite unstable and microsattelite-unstable colorectal carcinogenesis, but more frequently in the latter subgroup. PMID: 14691305
    20. Data indicate that activin A and activin receptors IIA and IIB may be involved in the regulation of germ cell proliferation in the human ovary during the period leading up to primordial follicle formation. PMID: 14738881
    21. Mutations highly frequent in microsatellite unstable(MSI-H) colon cancers and cause loss of ACVR2, indicating biallelic gene nactivation. Loss of activin signaling through mutation of ACVR2 may have role in genesis of MSI-H colorectal cancer. PMID: 14988818
    22. demonstrates that truncating mutations of the ACVR2 gene result in a significant reduction in activin mediated cell signaling. Inactivation of ACVR2 is a common event in prostate cancer and may play an important role in the development of prostate cancer PMID: 16337854
    23. structure of the ternary complex representing the signaling competent complex of BMP-2 bound to the entire extracellular domains of both its type I receptor, BMPR-Ia, & its type II receptor, ActRII, at a resolution of 2.2 angstroms PMID: 16672363
    24. Activin is growth suppressive and enhances migration in colon cancer. PMID: 17258738
    25. RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal PMID: 17472960
    26. Inhibin/activin BA subunit, follistatin, and activin receptor proteins and mRNAs are present in the human fetal palate. PMID: 18001154
    27. Populations with different ancestors (Iceland/Norway-Australia/New Zealand) demonstrate a common maternal pre-eclampsia susceptibility locus on chromosome 2q22-23, may suggests a general role of this locus, and possibly the ACVR2A gene, in pre-eclampsia. PMID: 18781190
    28. The -1 bp frameshift mutation rates of TGFBR2 and ACVR2 microsatellite sequences are dependent upon the human DNA Mismatch PMID: 18941508
    29. It remains unclear what role, if any, ACVR2A polymorphisms play in pre-eclampsia risk, at least in these Australian families. PMID: 19126782
    30. ActRII signaling is required for prostatic cancer cell and neuroblastoma cell viability, with ActRII mediating cell fate via the regulation of cell adhesion PMID: 19308291
    31. The four most frequently mutated genes in colorectal cancers with microsatellite instability were ACVR2 (92%), TAF1B (84%), ASTE1/HT001 (80%) and TGFBR2 (77%). PMID: 19503063

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 數據庫鏈接:

    HGNC: 173

    OMIM: 102581

    KEGG: hsa:92

    STRING: 9606.ENSP00000241416

    UniGene: Hs.470174



主站蜘蛛池模板: 欧美丰满熟妇xx猛交| 国产一区视频一区欧美| 久久久亚洲精品一区二区三区| 牛牛视频一区二区三区| 无码国内精品人妻少妇| 一本大道久久香蕉成人网 | 经典三级欧美在线播放| 亚洲人成网站色www| 熟女少妇内射日韩亚洲| 麻豆熟妇人妻xxxxxx| 久久综合亚洲欧美成人| 亚洲五月天综合| 亚洲久悠悠色悠在线播放| 免费无人区男男码卡二卡| 97超碰国产精品无码分类| 亚洲色国产欧美日韩| 亚洲国产中文字幕在线视频综合| 成人欧美一区二区三区在线| 亚洲aⅴ在线无码播放毛片一线天 吃奶摸下高潮60分钟免费视频 | 国产亚洲一区二区在线观看| 超碰国产精品人人做人人爱| 女人摸下面自熨视频在线播放| 色欲色香天天天综合vvv| 韩国精品福利一区二区三区 | 一本久道高清无码视频| 久久久国产99久久国产久麻豆| 亚洲人成无码网站在线观看| 中文字幕一区二区三区精彩视频| 狠狠色噜噜狼狼狼色综合久| 久久www成人片免费看| 国产精品视频一区二区噜噜| 久久久亚洲精华液精华液精华液| 手机看黄av免费网址| 国产精品一区二区 尿失禁| 国产男女爽爽爽免费视频| 四虎影视88aa久久人妻| 伊人精品成人久久综合97| 亚洲成av人片不卡无码| 亚洲337少妇裸体艺术| 97熟女毛毛多熟妇人妻aⅴ| 亚洲精品天堂成人片av在线播放|