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ACTRT1 Antibody

  • 中文名稱：
    ACTRT1兔多克隆抗體
  • 貨號：
    CSB-PA001255LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human smooth muscle tissue using CSB-PA001255LA01HU at dilution of 1:100
    • Immunofluorescence staining of PC-3 cells with CSB-PA001255LA01HU at 1:100,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ACTRT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ACTRT1
  • 別名：
    ACTRT1 antibody; ARPT1 antibody; HSD27Actin-related protein T1 antibody; ARP-T1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Actin-related protein T1 protein (201-376AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ACTRT1 Antibody (CSB-PA001255LA01HU)，的標記方式是Non-conjugated。對于ACTRT1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001255LB01HU ACTRT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA001255LC01HU ACTRT1 Antibody, FITC conjugated
    Biotin CSB-PA001255LD01HU ACTRT1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression.
  • 基因功能參考文獻：
    1. Study identified mutations in the ACTRT1 gene, which encodes actin-related protein T1 (ARP-T1), in two of the six families with Bazex-Dupre-Christol syndrome (BDCS) that were examined in this study. ARP-T1 was found to directly bind to the GLI1 promoter, thus inhibiting GLI1 expression, and loss of ARP-T1 led to activation of the Hedgehog pathway in individuals with BDCS. PMID: 28869610
    2. Describes the discovery of two actin-related proteins as major components in a cytoskeletal, nonmotile structure of bull spermatozoa, suggesting that certain members of this family of proteins may serve functions other than nucleation of actin filaments. PMID: 12243744
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Nucleus.
  • 蛋白家族：
    Actin family
  • 組織特異性：
    In skin, expressed in the basal, spinous and granular layers of the epidermis. Also expressed in hair follicles, sebaceaous glands, eccrine sweat glands and semen.
  • 數據庫鏈接：

    HGNC: 24027

    OMIM: 300487

    KEGG: hsa:139741

    STRING: 9606.ENSP00000360165

    UniGene: Hs.680125



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