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  4. ACTR8 Antibody

ACTR8 Antibody

  • 中文名稱：
    ACTR8兔多克隆抗體
  • 貨號：
    CSB-PA872523LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ACTR8 antibody at 16µg/ml
      Lane 1: A549 whole cell lysate
      Lane 2: HCT116 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 71, 59, 37 kDa
      Observed band size: 71 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ACTR8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ACTR8
  • 別名：
    Actin-related protein 8 antibody; Actr8 antibody; ARP8_HUMAN antibody; hArp8 antibody; INO80 complex subunit N antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Actin-related protein 8 protein (35-175AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ACTR8 Antibody (CSB-PA872523LA01HU)，的標記方式是Non-conjugated。對于ACTR8 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA872523LB01HU ACTR8 Antibody, HRP conjugated ELISA
    FITC CSB-PA872523LC01HU ACTR8 Antibody, FITC conjugated
    Biotin CSB-PA872523LD01HU ACTR8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex.
  • 基因功能參考文獻：
    1. Plays a regulatory role in the binding of Arp8 to DNA. PMID: 25299602
    2. Binding studies reveal that Arp8 and the Arp8-Arp4-actin-HSA sub-complex of INO80 strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting that Arp8 functions as a nucleosome recognition module. PMID: 22977180
    3. These results suggest that ARP8 is required for the recruitment of the mammalian INO80 complex to the laser-induced DNA damage sites. PMID: 20971067
    4. Expression of truncated hArp8 proteins and depletion of endogenous hArp8 by RNA interference caused misalignment of mitotic chromosomes, suggesting that chromosome-associated hArp8 has a role in chromosome behavior. PMID: 18163988
  • 亞細胞定位：
    Nucleus. Chromosome. Note=Specifically localizes to mitotic chromosomes.
  • 蛋白家族：
    Actin family, ARP8 subfamily
  • 數據庫鏈接：

    HGNC: 14672

    KEGG: hsa:93973

    STRING: 9606.ENSP00000336842

    UniGene: Hs.412186



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