在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACTN1 Antibody

  • 中文名稱:
    ACTN1兔多克隆抗體
  • 貨號:
    CSB-PA906019
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA906019(ACTN1 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA906019(ACTN1 Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    actinin 1 smooth muscle antibody; Actinin alpha 1 antibody; actinin; alpha 1 antibody; ACTN 1 antibody; Actn1 antibody; ACTN1_HUMAN antibody; Alpha Actinin 1 antibody; Alpha actinin cytoskeletal isoform antibody; Alpha-actinin cytoskeletal isoform antibody; Alpha-actinin-1 antibody; BDPLT15 antibody; F actin cross linking protein antibody; F-actin cross-linking protein antibody; FLJ40884 antibody; FLJ54432 antibody; Non muscle alpha actinin 1 antibody; Non-muscle alpha-actinin-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ACTN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
  • 基因功能參考文獻:
    1. these results indicate that increased alpha-actinin-1 expression destabilizes E-cadherin-based adhesions, which is likely to promote the migratory potential of breast cancer cells. Furthermore, our results identify a-actinin-1 as a candidate prognostic biomarker in basal-like breast cancer. PMID: 29742177
    2. provide a structural model of regulation of the actin crosslinking activity of alpha-actinin-1 where calcium induced structural stabilisation causes fastening of the juxtaposed actin binding domain, leading to impaired capacity to crosslink actin PMID: 27272015
    3. our 11 patients with macrothrombocytopenia related to ACTN1 mutation are characterized by an isolated autosomal dominant mild thrombocytopenia, with low bleeding tendency. PMID: 28562514
    4. Calcium modulates calmodulin-ACTN1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. PMID: 28130124
    5. Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression PMID: 27208173
    6. This suggests that a precise dosage of PC2 is necessary for an adequate mechanosensitive alpha-actinin recruitment at junctions. PMID: 27575580
    7. The present study identified a de novo mutation in ACTA1 (c.350A>G; p.Asn117Ser) in a Chinese patient using targetcapture sequencing of a panel containing 125 known causal genes for inherited muscle diseases. PMID: 27357517
    8. Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites. PMID: 26609810
    9. Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy. PMID: 26096820
    10. The authors show that the microtubule binding protein EB1 (end-binding protein 1), a key regulator of microtubule dynamics, can bind directly to filamentous actin (F-actin) F-actin. PMID: 26854759
    11. Several dominantly inherited congenital macrothrombocytopenia-associated mutations that are located within the actinin-1 actin-binding domain cause increased binding of actinin-1 to actin filaments and enhance filament bundling in vitro. PMID: 26879394
    12. Data indicate that alpha-actinin (110 kDa) autoantibody was characterized as a major target in lupus nephritis (LN) patients positive for Anti-membrane autoantibodies (MbA). PMID: 26071203
    13. ACTN1 determines the motility of keratinocytes by regulating the organization of the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cell speed, lamellipodial dynamics, and directed migration PMID: 25431851
    14. ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration PMID: 25429109
    15. ACTN1-related thrombocytopenia is characterized by mild course with platelet macrocytosis and low risk for bleeding. PMID: 25361813
    16. A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family. PMID: 24069336
    17. The C-terminal polybasic region of CYTH2 participates in interacting directly with the EFh2 domain of ACTN1. PMID: 22659138
    18. Loss of dorsal stress fibers either by depleting alpha-actinin-1 or Rac1 results in a beta-actin accumulation at the leading edge in migrating and spreading cells. PMID: 23132927
    19. Actinin-alpha1 readily forms heterodimers composed of monomers that may have different properties and interacting proteins, altering our view of non-muscle actinin, thus altering our view of non-muscle actinin function. PMID: 23557398
    20. Transduction of mouse fetal liver-derived megakaryocytes with disease-associated ACTN1 variants caused a disorganized actin-based cytoskeleton in megakaryocytes. PMID: 23434115
    21. Alpha actinin 1, a cytoskeleton protein implicated in inflammatory/degenerative autoimmune diseases, might be regarded as a novel multiple sclerosis autoantigen. PMID: 23139387
    22. We conclude that alpha-actinin stabilizes Ca(V)1.2 at the plasma membrane and that its displacement by calcium-calmodulin triggers calcium-induced endocytosis of Ca(V)1.2, thus providing an important negative feedback mechanism for calcium influx. PMID: 23664615
    23. The alpha-actinin/EWI motif-containing protein 2 (EWI-2) complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and structures involved in T cell recognition. PMID: 22689882
    24. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells. PMID: 21474972
    25. Identification of a 31 kD amino-terminal fragment of alpha-actinin protein, named mactinin, that promotes monocyte/macrophage maturation in vitro. PMID: 10029173
    26. Mactinin is a novel inducer of Hsp90 activity on monocytes and may serve to perpetuate and augment monocytic activation. PMID: 19715605
    27. cathepsin X overexpression reduced LFA-1 clustering and induced an intermediate affinity LFA-1 conformation that is known to associate with alpha-actinin-1. PMID: 19750481
    28. the focal adhesion component alpha-actinin interacts with syndecan-4 in a beta-integrin-independent manner PMID: 12493766
    29. an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking PMID: 12837758
    30. the dynamics of alpha-actinin are important for PI 3-kinase-induced reorganization of the actin cytoskeleton PMID: 15710624
    31. GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 PMID: 16190873
    32. S1P-induced recruitment of S1P1 to CEM fractions promotes PI3 kinase-mediated Tiam1/Rac1 activation required for alpha-actinin-1/4-regulated cortical actin rearrangement and EC barrier enhancement PMID: 16195373
    33. Alpha-actinin plays a role in regulating cell survival through stabilization of focal adhesions and regulation of TNF-alpha-induced survival signaling. PMID: 16807302
    34. Results show that the interaction between ICAM-5 and alpha-actinin is mediated through binding of positively charged amino acids near the transmembrane domain of ICAM-5, and this interaction may play an important role in neuronal differentiation. PMID: 16820411
    35. Interaction of alpha 1 actinin with ICAM-1 is required for leukocyte extravasation. PMID: 16951376
    36. Molecular dynamics method was applied to investigate the mechanical behaviour of the human skeletal muscle alpha-actinin. PMID: 17115122
    37. there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning PMID: 17311919
    38. ACT1 is de-expressed in endometriosis and endometrioid carcinoma compared with normal uterine epithelium. PMID: 17525629
    39. Alpha-actinin-1 phosphorylation at Y12 plays a crucial role in pressure-activated cell adhesion and mechanotransduction by facilitating Src recruitment to beta(1)-integrin, and consequently the association of focal adhesion kinase with Src. PMID: 17898132
    40. Taken together, alpha-actinin not only attaches TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. PMID: 17944866
    41. study examines the mechanism by which phosphoinositide binding regulates alpha-actinin function PMID: 17965186
    42. A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three organs and may represent general cancer-related splicing events. PMID: 18353764
    43. alpha-actinin-1 may play a role in human glomerular disease PMID: 18408146
    44. two sm-titin Zq domains interact with each other and with the two R2-R3 sites in the alpha-actinin central rod PMID: 18519573
    45. interaction of GNE with alpha-actinin 1 might point to its involvement in alpha-actinin mediated processes PMID: 18560563
    46. ICAM-2 mediates suppression of metastatic phenotype and the interaction of ICAM-2/alpha-actinin/actin represents the first complete membrane-linker protein-actin linkage to impact tumor cell motility in vitro and metastatic potential in an in vivo model. PMID: 18978946
    47. Data describe alterations of myocardial intercellular and cell-matrix contacts in hypertrophic tissue, and show intracellular translocation of beta-catenin, alpha-actinin and chondroitin sulfate proteoglycan 6 in both an animal model and in LVH patients. PMID: 19094982

    顯示更多

    收起更多

  • 相關疾病:
    Bleeding disorder, platelet-type 15 (BDPLT15)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction. Cell projection, ruffle.
  • 蛋白家族:
    Alpha-actinin family
  • 數據庫鏈接:

    HGNC: 163

    OMIM: 102575

    KEGG: hsa:87

    STRING: 9606.ENSP00000377941

    UniGene: Hs.235750



主站蜘蛛池模板: 久久青青草原精品国产app| 色欲久久久天天天综合网精品| 女女同性av片在线观看免费| 人人澡人人曰人人摸看| 清纯小美女主播流白浆| 精品少妇无码av无码专区| 99riav国产精品视频| 国产麻豆精品av在线观看| 久久精品国产99久久久小说| 伊人久久精品无码av一区| 久久人妻少妇嫩草av无码专区 | 黑人大战亚洲人精品一区| a毛看片免费观看视频| 亚洲sm另类一区二区三区| 中文字幕亚洲欧美在线不卡| 色综合久久无码中文字幕| 亚洲精品自偷自拍无码| 少妇无码av无码专区线y| 亚洲精品中文字幕无码蜜桃| 一性一交一口添一摸视频 | 免费无遮挡无码视频网站| 日日摸日日碰夜夜爽免费| 国产欧美日韩另类精彩视频| 久久综合伊人77777麻豆| 精品无码一区二区三区电影| 精品国产免费观看久久久| 99re久久精品国产首页| 97精品久久久久中文字幕| 亚洲色无码专线精品观看| 五月激情婷婷丁香综合基地| 一本无码久本草在线中文字幕dvd 337p日本欧洲亚洲大胆裸体艺术 国产av一区二区三区 | 免费人成网站视频在线观看国内| 久99久热只有精品国产15| 粗了大了 整进去好爽视频| 真人做人60分钟啪啪免费看| 吃奶揉捏奶头高潮视频| 精品久久久无码人妻字幂| 久久久综合九色综合88| 国产乱子伦一区二区三区四区五区| 国产麻豆剧传媒精品国产av| 成人欧美一区二区三区黑人免费|