在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ACTL6A Antibody

ACTL6A Antibody

  • 中文名稱：
    ACTL6A兔多克隆抗體
  • 貨號：
    CSB-PA001236GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ACTL6A
  • 別名：
    53 kDa BRG1 associated factor A antibody; 53 kDa BRG1-associated factor A antibody; ACL6A_HUMAN antibody; Actin like 6A antibody; Actin like protein 6A antibody; Actin related protein 4 antibody; Actin related protein antibody; Actin related protein Baf53a antibody; Actin-like protein 6A antibody; Actin-related protein Baf53a antibody; ACTL 6 antibody; ACTL 6A antibody; ACTL6 antibody; ACTL6A antibody; Arp4 antibody; ARPN BETA antibody; ArpNbeta antibody; BAF 53A antibody; BAF complex 53 kDa subunit antibody; BAF53 antibody; BAF53A antibody; BRG1 associated factor antibody; BRG1-associated factor 53A antibody; hArpN beta antibody; INO80 complex subunit K antibody; INO80K antibody; MGC5382 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human ACTL6A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
  • 基因功能參考文獻：
    1. hese results suggest that BAF53a may be a novel prognostic factor for glioma patients, and that BAF53 may facilitate glioma progression by promoting proliferation, invasion, and associate with EMT. Therefore, BAF53a could be a potential promising biomarker and a target for the treatment of glioma. PMID: 29039584
    2. ACTL6A gene mutation analysis should be considered in patients with intellectual disability, learning disabilities, or developmental language disorder. PMID: 28649782
    3. ACTL6A and p63 collaborate as oncogenic drivers in head and neck squamous cell carcinoma (HNSCC). PMID: 28041841
    4. Study shows high expression level of ACTL6A in osteosarcoma tissues and associates with poor survival providing evidence that ACTL6A promotes osteosarcoma cell metastasis through epithelial-mesenchymal transition. PMID: 28260090
    5. ACTL6A protein expression predicts poor prognosis of hepatocellular carcinoma and metastasis. PMID: 26698646
    6. BAF53 is prerequisite for maintaining the structural integrity of chromosomal subdomains. PMID: 26242195
    7. These results indicate that failure to downregulate the BAF53a subunit may contribute to the pathogenesis of rhabdomyosarcoma, and suggest that BAF53a may represent a novel therapeutic target for this tumor. PMID: 23728344
    8. Data show that ACTL6a prevents SWI/SNF complex binding to promoters of KLF4 and other differentiation genes and that SWI/SNF catalytic subunits are required for full induction of KLF4 targets. PMID: 23395444
    9. The beta-actin-Arp4 complex formation might be a crucial feature in some chromatin-modifying enzyme complexes, such as the Brg1 complex. PMID: 22573825
    10. These results suggest that activated expression of the E6 and E7 genes of integrated HPV is dependent on BAF53-dependent higher-order chromatin structure or nuclear motor activity. PMID: 21821000
    11. study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells;innate function of Baf53-containing complexes appears to be transcriptionally suppressive PMID: 21699904
    12. data show that BAF53 shuttles between the cytoplasm and nucleus in an energy-dependent manner, and suggest that BAF53 can play a role distinct from its previously recognized function in transcriptional regulation PMID: 14503849

    顯示更多

    收起更多

  • 相關疾病：
    ACTL6A mutations have been found in patients with intellectual disability of variable severity, developmental delay, dysmorphic features and digit abnormalities. Additional features may include genitourinary and cardiac defects. The disease phenotype resembles Coffin-Siris syndrome and brachymorphism-onychodysplasia-dysphalangism syndrome.
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Actin family
  • 數據庫鏈接：

    HGNC: 24124

    OMIM: 604958

    KEGG: hsa:86

    STRING: 9606.ENSP00000397552

    UniGene: Hs.435326



主站蜘蛛池模板： 久久久国产精品| 国产精品成人观看视频| 亚洲午夜av久久久精品影院色戒| 久久久久亚洲精品中文字幕| 欧美丰满老熟妇xxxxx性| 在线日产精品一区| 无码人妻专区免费视频| 特黄熟妇丰满人妻无码| 免费无码国产v片在线观看| 亚洲中文字幕乱码av波多ji| 人人妻人人妻人人人人妻人人| 国产特级毛片aaaaaa高清| 欧美巨鞭大战丰满少妇| 久久久噜噜噜久久熟女aa片| 国产成人av在线影院无毒| 亚洲六月丁香六月婷婷| 色婷婷综合中文久久一本| 国产精品久久久久蜜臀| 草裙社区精品视频三区免费看 | 免费无码黄动漫十八禁| 国产午夜福利不卡在线秋霞秋霞| 国产成人精品三级麻豆| 久久久久人妻精品一区二区三区| 日本www一道久久久免费| 国产福利在线永久视频| 国产精品亚洲一区二区| 国产亚洲情侣一区二区无| 亚洲 欧洲 日韩 综合在线| 日本丰满熟妇hd| 一区二区三区在线 | 网站| 欧洲一卡2卡3卡4卡国产| 久久人人97超碰国产精品| 亚洲丁香五月天缴情综合| 人人色在线视频播放| 国内精品美女a∨在线播放| 国产精品久久毛片| 东北妇女精品bbwbbw| 人妻少妇精品视频无码专区| 日韩精品成人av在线观看| 欧美黑人巨大xxxxx| 亚洲中文久久精品无码照片|