在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACSL5 Antibody, FITC conjugated

  • 中文名稱:
    ACSL5兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA891734HC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ACSL5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ACSL5 antibody; ACS5 antibody; FACL5 antibody; UNQ633/PRO1250 antibody; Long-chain-fatty-acid--CoA ligase 5 antibody; EC 6.2.1.3 antibody; Arachidonate--CoA ligase antibody; EC 6.2.1.15 antibody; Long-chain acyl-CoA synthetase 5 antibody; LACS 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Long-chain-fatty-acid--CoA ligase 5 protein (33-683AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells.
  • 基因功能參考文獻:
    1. our study has demonstrated that ACS5 expression was increased in colorectal cancer (CRC) cells and CRC tissues and its upregulation closely correlated to poor tumor differentiation and excess muscular layer in patients with CRC PMID: 28808653
    2. These results suggest that ACSL1, ACSL4 and ACSL5 expression is regulated by ER signaling pathways and ACSL5 is a potential novel biomarker for predicting prognosis of breast cancer patients. PMID: 28498416
    3. Functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping was identified as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Delta20 molecules is involved in migraine pathology. PMID: 27189022
    4. colorectal adenocarcinomas with low (n=41; group 1) or high (n=31; group 2) ACSL5 levels were identified. In a one-year follow-up, tumour recurrence was significantly increased in group 1. PMID: 28153554
    5. ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity. The molecular pathway is probably relevant for intestinal homeostasis, overwhelmed by other pathways in carcinogenesis. PMID: 25356045
    6. Uncoupling of ACSL5 and mitochondrial mortalin by mutated TP53 could be important in colorectal carcinogenesis. PMID: 24770931
    7. Down-regulation of ACSL5 is associated with colorectal cancer. PMID: 24222123
    8. Levels of acyl-coenzyme A synthetase 5 in urothelial cells and corresponding neoplasias reflect cellular differentiation. PMID: 23348389
    9. High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells PMID: 22163040
    10. The data strongly indicate that human but not rat acyl-CoA synthetase 5 is sensitive to triacsin C and does not compensate for other triacsin C-sensitive ACSL isoforms. PMID: 22171129
    11. Increased ACSL5 is associated with Fatty Liver. PMID: 20470896
    12. expression of ACS5 in the gastric body and the small intestine with metaplasia or heterotopia PMID: 15736044
    13. ACS5 is a very suitable marker molecule for the detection of villus atrophy in the small intestine. PMID: 15809837
    14. SREBP-1c-mediated insulin regulation of acyl-CoA synthestase 5 expression indicate that ACS-5 is involved in the anabolic fate of fatty acids. PMID: 16198472
    15. Existence of a link between ACSL5 genotype and diet responsiveness. PMID: 17495181
    16. Suggest an ACSL5-dependent regulatory mechanism that contributes to the cellular renewal along the crypt-villus axis in human small intestine. PMID: 17681178
    17. Oncostatin M directly lowers the plasma triglycerides in hyperlipidemia by stimulating the transcription of ACSL3/5 in the liver. PMID: 17761945
    18. Expression of ACSL5 in human epidermis is reported. PMID: 18228202
    19. These results indicate that ACSL5 is a critical factor for survival of glioma cells under acidic tumor microenvironment. PMID: 18806831
    20. These results reveal a mechanism for elevated transcription of ACSL5 in skeletal muscle of carriers of the rs2419621(T) allele, associated with more rapid diet-induced weight loss. PMID: 19218499

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion. Endoplasmic reticulum. Mitochondrion outer membrane; Single-pass type III membrane protein. Endoplasmic reticulum membrane; Single-pass type III membrane protein. Cell membrane.
  • 蛋白家族:
    ATP-dependent AMP-binding enzyme family
  • 數據庫鏈接:

    HGNC: 16526

    OMIM: 605677

    KEGG: hsa:51703

    STRING: 9606.ENSP00000348429

    UniGene: Hs.11638



主站蜘蛛池模板: 777米奇色狠狠俺去啦| 国产精品成人片在线观看| 99热久久这里只精品国产www| 久热这里只有精品12| 亚洲春色在线视频| 五月天激情电影| 亚洲暴爽av人人爽日日碰| 国产精品系列无码专区| 大肉大捧一进一出好爽| 无遮无挡三级动态图| 日韩爆乳一区二区无码| 亚洲乱码在线卡一卡二卡新区| 激情五月婷婷| 先锋影音xfyy5566男人资源| 玩弄丰满熟妇xxxxx性60| 国产成人一区二区不卡免费视频| 香港三级精品三级在线专区| 少妇被爽到高潮动态图| 亚洲三区在线观看内射后入| 天天综合网亚在线| 性高朝久久久久久久| 国产亚洲精久久久久久无码苍井空| 人妻丰满熟妞av无码区| 老司机久久精品最新免费| 中文日产幕无线码6区收藏| 青青草原综合久久大伊人精品 | 99香蕉国产精品偷在线观看| 成片免费观看视频大全| 亚洲综合色在线观看一区| 久久久精品一区aaa片| 国产精品久久久久野外| 国产成人影院一区二区三区| 国产午夜福利不卡在线秋霞秋霞| 少妇高潮一区二区三区99| 极品嫩模高潮叫床| 亚洲精品在看在线观看| 国产裸体舞一区二区三区 | 又黄又爽又色的免费网站| 久久久久成人片免费观看蜜芽| 国产va在线观看免费| 十八禁啪啪无遮挡网站|