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ACOT8 Antibody

  • 中文名稱:
    ACOT8兔多克隆抗體
  • 貨號:
    CSB-PA000805
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using ACOT8 Polyclonal Antibody
    • Western Blot analysis of MCF7 PC-12 cells using ACOT8 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ACOT8
  • 別名:
    ACOT8 antibody; ACTEIII antibody; PTE1 antibody; Acyl-coenzyme A thioesterase 8 antibody; Acyl-CoA thioesterase 8 antibody; EC 3.1.2.1 antibody; EC 3.1.2.11 antibody; EC 3.1.2.2 antibody; EC 3.1.2.3 antibody; EC 3.1.2.5 antibody; Choloyl-coenzyme A thioesterase antibody; EC 3.1.2.27 antibody; HIV-Nef-associated acyl-CoA thioesterase antibody; Peroxisomal acyl-CoA thioesterase 2 antibody; PTE-2 antibody; Peroxisomal acyl-coenzyme A thioester hydrolase 1 antibody; PTE-1 antibody; Peroxisomal long-chain acyl-CoA thioesterase 1 antibody; Thioesterase II antibody; hACTE-III antibody; hACTEIII antibody; hTE antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ACOT8.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation.; (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression.
  • 基因功能參考文獻:
    1. In summary, lipolytic enzyme ACOT8 is frequently upregulated in HCC clinical specimens. More importantly, ACOT8 silencing leads to inhibition of cell growth in HCC in vitro. PMID: 24788990
    2. Acyl-CoA thioesterase 8 is a specific protein related to nodal metastasis and prognosis of lung adenocarcinoma. PMID: 23540296
    3. ACOT4 and ACOT8 are responsible for the termination of beta-oxidation of dicarboxylic acids of medium-chain length with the concomitant release of the corresponding free acids PMID: 16141203
    4. SREBP2 modulates brain palmitoyl-coa hydrolase gene transcription. PMID: 16335799
    5. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol. PMID: 17624024

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  • 亞細胞定位:
    Peroxisome matrix.
  • 蛋白家族:
    C/M/P thioester hydrolase family
  • 組織特異性:
    Detected in a T-cell line (at protein level). Ubiquitous.
  • 數據庫鏈接:

    HGNC: 15919

    OMIM: 608123

    KEGG: hsa:10005

    STRING: 9606.ENSP00000217455

    UniGene: Hs.444776



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