在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ACOD1 Antibody, Biotin conjugated

ACOD1 Antibody, Biotin conjugated

  • 中文名稱(chēng)：
    ACOD1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA011825LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) ACOD1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ACOD1
  • 別名：
    ACOD1 antibody; Aconitate decarboxylase 1 antibody; Aconitate decarboxylase antibody; CAD antibody; Cis aconitate decarboxylase antibody; Immune responsive gene 1 protein homolog antibody; Immune-responsive gene 1 protein homolog antibody; Immunoresponsive 1 homolog (mouse) antibody; Irg1 antibody; IRG1_HUMAN antibody; OC116 antibody; OPTB1 antibody; TCTIRC7 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cis-aconitate decarboxylase protein (57-257AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.
  • 基因功能參考文獻(xiàn)：
    1. In conclusion, we found that IRG1 promoted MHC I level in macrophages membrane via ROS-STAT1/3-TAP1 pathway. Besides, IRG1 could activate the pentose phosphate pathway to promote production of ROS depending on NADPH oxidases. PMID: 28477473
    2. findings suggest that polymorphisms in the immunoresponsive gene 1 (IRG1) gene are associated with the immune response to hepatitis B vaccination; observed that IRG1 inhibited the HBV life cycle and that IRG1 rs17385627 allele 'A' was more effective than rs17385627 allele 'T' at eliminating HBV in HepG2.2.15 cell PMID: 28004399
    3. Respiratory syncytial virus infection induced IRG1 expression in human A549 cells and in the lung tissues of respiratory syncytial virus -infected mice and respiratory syncytial virus infection or IRG1 overexpression promoted reactive oxygen species production. PMID: 27252532
    4. IRF1 is a transcriptional regulator of IRG1 in human macrophages. PMID: 26872335
    5. We identified IRF1 as a transcriptional regulator of IRG1 expression in both human and mouse macrophages under inflammatory conditions. PMID: 26872335
    6. IRG1/CAD associates with mitochondria in human macrophages under inflammatory conditions such as LPS and/or IFNg. PMID: 26872335
    7. Taken together, the results show that IRG1 is expressed by human monocytes, macrophages and dendritic cells and that it is rapidly induced in both human and murine macrophages under inflammatory conditions such as LPS, TNFa and IFNg. PMID: 26872335
    8. Findings revealed that IRG1 is a candidate oncogene that is amplified in glioma and is involved in novel mechanisms that influence glioma pathogenesis. PMID: 25216059
    9. inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxin tolerance. PMID: 23609450
    10. IRG1 links cellular metabolism with immune defense by catalyzing itaconic acid production PMID: 23610393
    11. Irg1 gene encodes an enzyme synthesizing itaconic acid from the TCA cycle intermediate cisaconitate. Furthermore, our data also show that IRG1 mediated itaconic acid production contributes to the antimicrobial activity of macrophages. PMID: 23610393
    12. Results indicated that the IRG1 gene is differentially expressed in human fetal PBMCs and LPS-stimulated adult PBMCs. PMID: 21424586

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    PrpD family
  • 組織特異性：
    Expressed in LPS-tolerized macrophages (at protein level). Expressed in peripheral blood mononuclear cells (PBMCs), microglia and macrophage cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 33904

    OMIM: 615275

    KEGG: hsa:730249

    STRING: 9606.ENSP00000366682

    UniGene: Hs.160789



主站蜘蛛池模板： 上司人妻互换hd无码| 国产成人亚洲综合色婷婷| 国产乱子伦三级在线播放| 精品av中文字幕在线毛片 | 国产精品免费看久久久无码| 久久中文字幕人妻熟av女蜜柚m| 伊人久久综合成人网| 欧美性群另类交| 热99re久久精品这里都是精品免费| 欧美人与动性xxxxx杂性| 欧美性猛交xxxx富婆| 成人a大片在线观看| 亚洲国产欧美在线人成最新| 国产美女极度色诱视频www| 青青青国产免a在线观看| 久久久久久无码精品人妻a片软件| 中文字幕av一区| 性生交大全免费看| 国产美女自卫慰水免费视频| 少妇人妻精品无码专区视频| 久久久精品日本一区二区三区| 老子午夜精品无码| 亚洲免费网站观看视频| 国产亚洲精品a在线观看下载| 蜜桃视频一区二区在线观看| 亚洲中文字幕在线第二页| 国产多人群p刺激交换视频| 超清无码波多野吉衣中文| 玩弄japan白嫩少妇hd小说| 国产又黄又刺激又高潮的网站 | 丝袜自慰一区二区三区| 69堂人成无码免费视频果冻传媒| 男人和女人做爽爽视频| 国产区图片区小说区亚洲区| 日韩国产网曝欧美第一页| 国产欧美日韩中文久久| 一区二区亚洲精品国产精华液| 欧美亚洲综合成人专区| 亚洲人成77777在线播放网站不卡 国产 | 欧洲野花视频天堂视频p 亚洲aⅴ天堂av天堂无码 | 国产午夜精品一区二区| 久青草国产97香蕉在线影院|