在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ACO2 Antibody

  • 中文名稱:
    ACO2兔多克隆抗體
  • 貨號:
    CSB-PA104784
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA104784(ACO2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA104784(ACO2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: CSB-PA104784(ACO2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ACO2
  • 別名:
    ACO 2 antibody; ACO2 antibody; ACON_HUMAN antibody; aconitase 2 antibody; Aconitase 2 mitochondrial antibody; Aconitase antibody; Aconitase2 antibody; Aconitate hydratase antibody; Aconitate hydratase mitochondrial antibody; ACONM antibody; Citrate hydro lyase antibody; Citrate hydro-lyase antibody; ICRD antibody; mitochondrial antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human ACO2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
  • 基因功能參考文獻:
    1. Aco2 activity correlated significantly with motor score, independence scale, and functional capacity of the Unified Huntington's Disease Rating Scale as well as disease duration. Our study provides a potential biomarker to assess the disease status of HD patients and PreHD carriers. PMID: 29160844
    2. Results suggest that ACO2 activity is reduced in peripheral lymphocytes of subjects with Alzheimer's disease and mild cognitive impairment and correlates with antioxidant protection PMID: 25322927
    3. Our study shows that autosomal recessive ACO2 mutations can cause either isolated or syndromic optic neuropathy. PMID: 25351951
    4. immunofluorescence staining localized ACO2 to the human sperm mid-piece. By immunoblotting, we demonstrated that the level of ACO2 protein in asthenozoospermic samples was significantly decreased compared with that in normal fertile men PMID: 24785945
    5. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity. PMID: 24429287
    6. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells PMID: 23709747
    7. Gastric cancer patients with lower ACO2 expression have a shorter survival time than those with higher ACO2 expression. PMID: 23550275
    8. Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2. PMID: 22405087
    9. these results suggest that p53 downregulation of mACON gene expression in human prostate carcinoma cells may not occur through the putative consensus p53 response elements found within the mACON promoter. PMID: 20607720
    10. abolishes oxidant-induced apoptosis PMID: 19524665
    11. Lon protease selectively recognizes and degrades the oxidized, hydrophobic form of aconitase after mild oxidative modification, but that severe oxidation results in aconitase aggregation, which makes it a poor substrate for Lon. PMID: 12198491
    12. ACO2 is often deleted in colorectal cancer but is unlikely to be the true target of the deletions PMID: 12746427
    13. The m-aconitase promoter is contained in a 153-bp 5' fragment lacking a TATA or CAAT sequence. Sp1 binding to specific Sp1 site is needed for promoter activity. Other transcription factors are recruited through protein-protein interactions. PMID: 16598741
    14. Manganese acts as an antagonist of iron, disrupting the enzymatic activity and gene expression of mACON and citrate metabolism in the prostate. PMID: 16625280
    15. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953
    16. This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19110265

    顯示更多

    收起更多

  • 相關疾病:
    Infantile cerebellar-retinal degeneration (ICRD); Optic atrophy 9 (OPA9)
  • 亞細胞定位:
    Mitochondrion.
  • 蛋白家族:
    Aconitase/IPM isomerase family
  • 數據庫鏈接:

    HGNC: 118

    OMIM: 100850

    KEGG: hsa:50

    STRING: 9606.ENSP00000216254

    UniGene: Hs.643610



主站蜘蛛池模板: 自拍偷在线精品自拍偷免费| 国产精品成人免费一区久久羞羞| 亚洲真人无码永久在线| 亚洲精品久久yy5099| 国产v亚洲v天堂a无码99| 无遮挡十八禁污污污网站| 久久久久国产精品无码免费看| 久久久欧美国产精品人妻噜噜| 超碰aⅴ人人做人人爽| 国产系列丝袜熟女精品网站| 成人国内精品久久久久一区 | 97国产精品人妻无码久久久| 宅男宅女精品国产av天堂| 俺去啦俺来也五月天| 国产偷窥熟女高潮精品视频| 全球av集中精品导航福利| 亚洲综合一区二区三区四区五区 | 97精品人人a片免费看| 国产精品a成v人在线播放| 青青草国产久久精品| 人妻熟女久久久久久久| 欧美成人一区二区三区片免费 | 国产a精彩视频精品视频下载| 色噜噜亚洲男人的天堂www| 欧美成人一区二区三区在线观看| 真实的国产乱xxxx在线| 一出一进一爽一粗一大视频免费的| 国产欧美综合在线观看第十页| 国产亚洲欧洲aⅴ综合一区| 人妻少妇无码精品视频区| 日本熟妇人妻xxxxx| 国产如狼似虎富婆找强壮黑人| 久久精品国产免费播| 狠狠综合久久av一区二区| 亚洲中文字幕永久在线全国| 欲色影视天天一区二区色香欲| av鲁丝一区鲁丝二区鲁丝三区| 国产日韩精品一区二区三区在线| 四虎亚洲精品成人a在线观看 | 在线观看国产日韩亚洲中 | 一个人看的视频www在线|