在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ABCE1 Antibody

ABCE1 Antibody

  • 中文名稱：
    ABCE1兔多克隆抗體
  • 貨號：
    CSB-PA802152
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 cells, human ovarian cancer tissue, Primary antibody: CSB-PA802152(ABCE1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ABCE1
  • 別名：
    2' 5' oligoadenylate binding protein antibody; 2''-5''-oligoadenylate-binding protein antibody; 2'5' oligoadenylate binding protein antibody; ABC 38 antibody; ABC38 antibody; ABCE 1 antibody; ABCE1 antibody; ABCE1_HUMAN antibody; ATP binding cassette sub family E (OABP) member 1 antibody; ATP binding cassette sub family E member 1 antibody; ATP-binding cassette sub-family E member 1 antibody; HuHP 68 antibody; HuHP68 antibody; OABP antibody; Ribonuclease 4 inhibitor antibody; Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor antibody; Ribonuclease L inhibitor antibody; RLI antibody; RNase L inhibitor antibody; RNASEL1 antibody; RNASELI antibody; RNS 4I antibody; RNS4I antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human ABCE1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage; this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway.; (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly.; (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
  • 基因功能參考文獻：
    1. Induction of ribosome rescue factors PELO and HBS1L is required to support protein synthesis when ABCE1 levels fall in platelets, including for hemoglobin production during blood cell development. PMID: 27681415
    2. ABCE1 is involved in histone biosynthesis and DNA replication and therefore is essential for normal S phase progression. PMID: 26985706
    3. The present study reported on the effects of ABCE1 overexpression on lung adenocarcinoma cells in vitro, demonstrating its enhancing effect on cell proliferation and invasiveness with simultaneous downregulation of p27 protein expression. PMID: 27314749
    4. ABCE1 plays an essential role in the progression and metastasis of lung cancers and may represent a valuable therapeutic target for the management of lung tumor PMID: 26733164
    5. miR-299-3p promotes the sensibility of lung cancer to doxorubicin through suppression of ABCE1, at least partly. Therefore, the disordered decreased of miR-299-3p and resulting ABCE1 up-expression may contribute to chemoresistance of lung cancer PMID: 26617714
    6. Expression of the ABCE1-silencing gene, transfected by electrotransfer, could inhibit the proliferation, invasion, and migration of thyroid cancer cells. PMID: 26600528
    7. Downregulation of ABCE1 via siRNA affects the sensitivity of lung cancer cells against chemotherapeutic agents. PMID: 25744244
    8. ABCE1 is closely associated with cell proliferation, invasion and migration in esophageal cancer and silencing the ABCE1 gene by electroporation can significantly reduce the proliferation, invasion and migration capacity PMID: 25815591
    9. ABCE1 is able to suppress RNA silencing in Nicotiana benthamiana plants, in mammalian HEK293 cells and in the worm Caenorhabditis elegans. PMID: 25659154
    10. ABCE1 is closely connected with the pathogenesis and development of oral cancer, which acts through the cellular pathways of 2-5A/RNase L. PMID: 25337191
    11. ABCE1 is closely connected with the pathogenesis and development of esophageal carcinoma, which act through the cellular pathways of 2-5A/RNase L. PMID: 24551278
    12. Studies indicate a strong sequence conservation of ABC-type ATPase ABCE1 in eukaryotes and archaea. PMID: 23266104
    13. ABCE1 protein regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis. (Review) PMID: 23008114
    14. Pulse chase experiments and immunoelectron microscopy shows that HIV-1 Gag associates transiently with ABCE1 during HIV-1 capsid assembly, including at the plasma membrane where assembly is completed. PMID: 17233757
    15. HIV-1, HIV-2, SIV mac239, and SIVagm Gag proteins form ABCE1-containing assembly intermediates during immature capsid formation, indicating that Gag proteins of these diverse retroviruses bind to ABCE1 despite the limited homology between these Gags. PMID: 14747530
    16. For binding of WT HIV-1 Gag to the cellular ATPase ABCE1, which facilitates HIV-1 capsid assembly, the basic residues in the nucleocapsid domain of Gag are required but the cysteine and histidine residues in the nucleocapsid domain are dispensable. PMID: 16275648
    17. During assembly of an immature HIV-1 capsid, HIV-1 Gag progresses through a pathway of sequential assembly intermediates that contain ABCE1, a cellular ATPase that was found to facilitate capsid formation. PMID: 11780123
    18. To form HIV-1 capsid assembly intermediates, HIV-1 Gag co-opts a complex found in infected and uninfected cells that contains the cellular ATPase ABCE1 and the RNA helicase DDX6, both of which facilitate HIV-1 capsid assembly. PMID: 22851315
    19. Report high expression level of ABCE1 mRNA and protein in human lung adenocarcinoma tissues and metastatic lymph nodes, which was also correlated with clinical stages. PMID: 22267055
    20. Pelota/Hbs1 induced dissociation of elongation complexes from ribosomes and release of peptidyl-tRNA, but only in the presence of ABCE1. PMID: 21448132
    21. Results suggest that ABCE1 plays an important role in the pathogenesis of human small cell lung cancer cell. PMID: 20372810
    22. NTP hydrolysis by ABCE1 is stimulated by posttermination complexes and is required for its ribosomal recycling activity. PMID: 20122402
    23. were able to confirm the excess of rare genetic variation among HIV-1-positive African-American individuals (n=53; Tajima's D=-2.34). These results highlight the potential importance of ABCE1's role in infectious diseases such as HIV-1. PMID: 19657357
    24. HIV-2 Gag associates with human HP68 in a cell-free system and that Gag proteins of HIV-2, simian immunodeficiency virus SIVmac239, and SIVagm associate with endogenous HP68 in primate cells, as is seen for HIV-1. PMID: 14747530
    25. overexpression in a permissive cell line had no significant effect on varicella zoster virus replication PMID: 15107989
    26. ABCE1 and its peptides could be target molecules in specific immunotherapy for HLA-A2(+) colon cancer patients. PMID: 15809757
    27. The primary role of ABCE-1 in the effect of TULA appears to be the recruitment of TULA to the sites of HIV-1 assembly where TULA interferes with the late steps of the HIV-1 life cycle. PMID: 18006034
    28. host protein essential for assembly of immature HIV-1 capsids PMID: 11780123

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Mitochondrion. Note=Localized to clusters of virus formation at the plasma membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCE family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 69

    OMIM: 601213

    KEGG: hsa:6059

    STRING: 9606.ENSP00000296577

    UniGene: Hs.12013



主站蜘蛛池模板： 亚洲欧洲免费无码| 中文字幕精品av乱码在线| 日本japanese漂亮丰满| 好男人社区www在线观看| 国产精品久线在线观看| 香港台湾经典三级a视频| 手机看黄av免费网址| 丰满熟女高潮毛茸茸欧洲视频| 亚洲国产欧美在线人成| 天天天天躁天天爱天天碰2018| 麻豆 美女 丝袜 人妻 中文| 国产精品成人永久在线四虎| 亚洲欧美人成网站aaa| 亚洲一卡2卡3卡4卡精品| 国产丰满老熟妇乱xxx1区| 扒开双腿吃奶呻吟做受视频| 亚洲欧洲美洲无码精品va| 亚洲精品自偷自拍无码| 免费能直接看黄的视频| 国产在线拍揄自揄拍免费下载 | www一区二区www免费| 少妇邻居内射在线| 在线观看一区二区三区国产免费| 在线观看免费人成视频网| av无码中出一区二区三区| 性暴力欧美猛交在线播放| 久久午夜无码鲁丝片午夜精品| 成人免费无遮挡无码黄漫视频| 无码专区―va亚洲v专区在线| 亚洲色欲色欲www成人网| 新版天堂资源中文8在线| 艳妇乳肉豪妇荡乳av无码福利| 国产精品久久久久久成人影院| 亚洲色欲在线播放一区| 亚洲旡码欧美大片| 国产亚洲精品美女久久久久| 久久夜色撩人精品国产小说| 国产精品亚洲a∨天堂| 无码人妻精品一区二区三区9厂| 午夜时刻免费入口| 午夜男女爽爽影院免费视频|