在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ABCC10 Antibody

  • 中文名稱:
    ABCC10兔多克隆抗體
  • 貨號:
    CSB-PA003282
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COS7 cells using MRP7 Polyclonal Antibody
    • Western Blot analysis of Jurkat A549 cells using MRP7 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ABCC10
  • 別名:
    ABCC10 antibody; ATP binding cassette; sub family C (CFTR/MRP); member 10 antibody; ATP binding cassette; subfamily C; member 10 antibody; ATP-binding cassette sub-family C member 10 antibody; EST182763 antibody; mFLJ00002 antibody; MRP7 antibody; MRP7_HUMAN antibody; Multidrug resistance associated protein 7 antibody; Multidrug resistance-associated protein 7 antibody; SIMRP7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Monkey
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human MRP7.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
  • 基因功能參考文獻:
    1. FOXM1 promotes 5-FU resistance by up-regulating ABCC10 expression in colorectal tumor cells. PMID: 28051999
    2. It is thus inferred, that ABCC10 expression in CWR22Rv1 cells is not S phase-specific but is primarily associated with cell proliferation. PMID: 28612064
    3. BAG3-mediated miRNA let-7g and let-7i inhibit proliferation and enhance apoptosis of human esophageal carcinoma cells by targeting the drug transporter ABCC10 and modulates cisplatin resistance. PMID: 26655271
    4. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10 PMID: 24431074
    5. ABCC10 expression is correlated with human breast cancer subtype using breast tissue microarrays. PMID: 24937672
    6. This report describes the ATPase activity of ABCC10 and further revealed ABCC10 localizes basolaterally using an in vitro system. The described work also identifies the tyrosine kinase sorafenib as an inhibitor of ABCC10. PMID: 23087055
    7. Study establishes that ABCC10 is able to modulate taxane resistance in vivo using a mouse model. PMID: 21576088
    8. Study establishes that ABCC10 confers resistance to several classes of agents including nucleoside analogs (cytabarine, dideoxycytidine) and epothilone B. PMID: 19118001
    9. This study shows that ABCC10 confers resistance to the anticancer agents taxanes and vinca alkaloids in vitro. PMID: 15256465
    10. First study to describe ABCC10's ability to transport physiological substrates, confirming that this protein, with low identity to ABCC1, was indeed a efflux pump. PMID: 12527806
    11. First study to describe structure and expression pattern of this transporter. PMID: 11146224
    12. Tetrandrine and 5-bromotetrandrine can both reverse multidrug resistance in K562 cells by reducing expression of MRP7. PMID: 22739155
    13. Multivariate regression analysis identified carriage of a composite genotype of ABCC10 rs2125739 to be associated with nevirapine plasma concentrations PMID: 22082652
    14. Tenofovir is a substrate for ABCC10, and genetic variability within the ABCC10 gene may influence tenofovir renal tubular transport and contribute to the development of kidney tubular dysfunction. PMID: 21628669
    15. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10) PMID: 19841739
    16. MRP7 has the facility for mediating the transport of conjugates such as E(2)17betaG indicates that it is a lipophilic anion transporter involved in phase III (cellular extrusion) of detoxification. PMID: 12527806
    17. The genomic organization and gene expression regulation of human multidrug resistance-associated protein 7 and a splicing variant MRP7A were identified PMID: 12566991
    18. A non-major histocompatibility complex MRP7 leader peptide ALALVRMLI binds to HLA-E and strongly inhibits natural killer (NK) cell-mediated lysis PMID: 16034073
    19. MDR1 expression, MRP1 expression, and MRP7 expression are refractory factors in head and neck cancer chemotherapy; induction of MRP7 expression is involved in drug resistance to natural products, especially to docetaxel in salivary gland adenocarcinoma PMID: 17203221
    20. ABCC10/MRP7 may confer vinorelbine resistance in non-small cell lung cancer PMID: 19082471

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
  • 組織特異性:
    [Isoform 1]: Specifically expressed in spleen.; [Isoform 2]: Widely expressed.
  • 數據庫鏈接:

    HGNC: 52

    OMIM: 612509

    KEGG: hsa:89845

    STRING: 9606.ENSP00000361608

    UniGene: Hs.55879



主站蜘蛛池模板: 成人午夜福利院在线观看| av淘宝国产在线观看| 亚洲制服丝袜av一区二区三区| 国产精品亚洲专区无码老司国| 自拍偷自拍亚洲精品牛影院| 69sex久久精品国产麻豆| 无码人妻视频一区二区三区| 亚洲成国产人片在线观看| 亚瑟av亚洲精品一区二区| 国产老熟女伦老熟妇露脸| 中文字幕乱码一区av久久不卡| 午夜福利不卡在线视频| 久久国产av影片| 搡老岳熟女国产熟妇| 粉嫩粉嫩的18在线观看| 又粗又硬又黄又爽的视频永久 | 1000部夫妻午夜免费| 亚洲精品白浆高清久久久久久| 狠狠躁夜夜躁人人爽天天古典 | 偷偷做久久久久网站| 亚洲国产精品久久精品成人网站| 亚洲精品综合欧美一区二区三区| 午夜成人理论无码电影在线播放| 女子spa高潮呻吟抽搐| 国自产拍偷拍精品啪啪模特| 色欲色香天天天综合网站| 国产成人18黄网站| 国产综合无码一区二区色蜜蜜| 丰满大爆乳波霸奶| 中国做爰国产精品视频| 疯狂三人交性欧美| 欧美亚洲一区二区三区| 西西人体大胆无码视频| 欧美人与zoxxxx另类| 脱岳裙子从后面挺进去在线观看| 永久黄网站色视频免费无下载| 国产免费高清69式视频在线观看| 伦埋琪琪电影院久久| 亚洲aⅴ无码专区在线观看| 老汉老妇姓交视频| 熟妇人妻中文字幕无码老熟妇|