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  4. AASS Antibody

AASS Antibody

  • 中文名稱：
    AASS兔多克隆抗體
  • 貨號：
    CSB-PA000779
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using AASS Polyclonal Antibody
    • Western Blot analysis of 293 NIH-3T3 A549 cells using AASS Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AASSAlpha-aminoadipic semialdehyde synthase antibody; mitochondrial antibody; LKR/SDH) [Includes: Lysine ketoglutarate reductase antibody; LKR antibody; LOR antibody; EC 1.5.1.8); Saccharopine dehydrogenase antibody; SDH antibody; EC 1.5.1.9)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human AASS.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.
  • 基因功能參考文獻：
    1. GR and KLF15 physically interact via low affinity GR binding sites within glucocorticoid response elements (GREs) for PRODH and AASS that contribute to combinatorial regulation with KLF15. PMID: 26088140
    2. Mitochondrial NADPH is crucial for AASS function PMID: 24847004
    3. Hyperlysinemia is caused by mutations in AASS PMID: 23570448
    4. Isolation and characterization of the mouse ortholog. PMID: 10567240
  • 相關疾病：
    Hyperlysinemia, 1 (HYPLYS1); 2,4-dienoyl-CoA reductase deficiency (DECRD)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    AlaDH/PNT family; Saccharopine dehydrogenase family
  • 組織特異性：
    Expressed in all 16 tissues examined with highest expression in the liver.
  • 數據庫鏈接：

    HGNC: 17366

    OMIM: 238700

    KEGG: hsa:10157

    STRING: 9606.ENSP00000377040

    UniGene: Hs.156738



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