在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AARS Antibody

  • 中文名稱:
    AARS兔多克隆抗體
  • 貨號:
    CSB-PA066208
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA066208(AARS Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA066208(AARS Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: K562 cells, Primary antibody: CSB-PA066208(AARS Antibody) at dilution 1/283, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AARS
  • 別名:
    AARS antibody; AI316495 antibody; Alanine tRNA ligase 1, cytoplasmic antibody; Alanine tRNA ligase antibody; Alanine tRNA ligase cytoplasmic antibody; Alanine--tRNA ligase antibody; Alanyl tRNA synthetase antibody; Alanyl tRNA synthetase cytoplasmic antibody; Alanyl-tRNA synthetase antibody; AlaRS antibody; C76919 antibody; CMT2N antibody; cytoplasmic antibody; EC 6.1.1.7 antibody; MGC37368 antibody; Renal carcinoma antigen NY REN 42 antibody; Renal carcinoma antigen NY-REN-42 antibody; SYAC_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Synthetic peptide of Human AARS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
  • 基因功能參考文獻:
    1. A large sequence divergence of the C-terminal domain (C-Ala) reshaped C-Ala in a way that changed the global architecture of alanyl-tRNA synthetase (AlaRS). This reshaping removed the role of C-Ala in prokaryotes for docking tRNA and instead repurposed it to form a dimer interface presenting a DNA-binding groove. PMID: 27911835
    2. Number of missense mutations in AARS expand the clinical spectrum and provide pheno-genotypic correlations in AARS-related neuropathies. PMID: 26032230
    3. A novel mutation in alanyl-tRNA synthetase causes a mild myeloneuropathy, a novel phenotype for patients with mutations in one of the tRNA synthetase genes. PMID: 25904691
    4. Loss-of-function alanyl-tRNA synthetase mutations cause an autosomal-recessive early-onset epileptic encephalopathy with persistent myelination defect. PMID: 25817015
    5. the pathological consequences of diminished tRNA synthetase editing activity, and thus translational infidelity, are dependent on the cell type and the extent of editing disruption PMID: 25422440
    6. in a family with distal hereditary motor neuropathy (dHMN), all 4 affected family members had a heterozygous missense mutation c.2677G>A (p.D893N) of (AARS), not found in the 4 unaffected members and control subjects; conclude AARS mutation caused dHMN in a Chinese family; AARS mutations result in not only a CMT phenotype but also a dHMN phenotype PMID: 22573628
    7. Methylation-mediated deamination of a CpG dinucleotide gives rise to the recurrent p.Arg329His alanyl-tRNA synthetase mutation in patients with Charcot-Marie-Tooth disease type 2N (CMT2N). PMID: 22009580
    8. We show here that mutations in AARS2 cause perinatal or infantile cardiomyopathy with near-total combined mitochondrial respiratory chain deficiency in the heart. PMID: 21549344
    9. cytoplasmic Alanyl-tRNA synthetase may have a role in dominant axonal Charcot-Marie-Tooth disease, as shown by its mutation in a major determinant for binding and aminoacylation PMID: 20045102

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Charcot-Marie-Tooth disease 2N (CMT2N); Epileptic encephalopathy, early infantile, 29 (EIEE29)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class-II aminoacyl-tRNA synthetase family
  • 數據庫鏈接:

    HGNC: 20

    OMIM: 601065

    KEGG: hsa:16

    STRING: 9606.ENSP00000261772

    UniGene: Hs.315137



主站蜘蛛池模板: 亚洲国产无套无码av电影| 国产精品国产三级欧美二区| 色噜噜亚洲男人的天堂| 国产精品自在拍在线播放| 无码精品国产一区二区免费 | 成人爽a毛片在线视频| 无码人妻一区二区三区免费看成人 | 人妻av无码一区二区三区| 精品一区二区三区无码视频| 国产99久久九九精品无码| 久久久这里只有精品10| 热99re久久国超精品首页| 国产精品久久久久久久久久| 美女高潮黄又色高清视频免费| 亚洲人成无码区在线观看| 亚洲欧洲精品无码av| 亚洲人毛茸茸bbxx| 国产成人一区二区三区影院动漫| 欧美精品亚洲精品日韩专区va | 少妇无码一区二区三区免费| 免费无码又爽又刺激高潮| 亚洲中文字幕在线第二页| 欧美影视精品久久| 国产jk白丝在线观看免费| 成人免费视频一区二区三区| 亚洲国产精彩中文乱码av| 四库影院永久国产精品地址 | 国产精品无码一区二区三区免费| 国产色婷婷五月精品综合在线| 中文日韩亚洲欧美制服| 久久精品高清一区二区三区| 少妇被躁爽到高潮无码文| 激情内射亚洲一区二区三区爱妻 | 亚洲精品你懂的在线观看| 麻花豆传媒剧国产免费mv观看| 日本高清色倩视频在线观看| 精品久久亚洲中文无码| 青草久久人人97超碰| 亚洲欧美不卡高清在线| 免费无码毛片一区二区app| 国产偷人妻精品一区二区在线|