在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AAK1 Antibody

AAK1 Antibody

  • 中文名稱：
    AAK1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA643571LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Mouse kidney tissue
      All lanes: AAK1 antibody at 2.5μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 104, 94 kDa
      Observed band size: 104 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA643571LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA643571LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) AAK1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    AAK1
  • 別名：
    AAK 1 antibody; Aak1 antibody; AAK1_HUMAN antibody; Adaptor associated kinase 1 antibody; Adaptor-associated kinase 1 antibody; AP2 associated kinase 1 antibody; AP2 associated protein kinase 1 antibody; AP2-associated protein kinase 1 antibody; DKFZp686F03202 antibody; DKFZp686K16132 antibody; FLJ23712 antibody; FLJ25931 antibody; FLJ31060 antibody; FLJ42882 antibody; FLJ45252 antibody; KIAA1048 antibody; MGC138170 antibody; MGC164568 antibody; MGC164570 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，AAK1 Antibody (CSB-PA643571LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于AAK1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA643571LB01HU AAK1 Antibody, HRP conjugated ELISA
    FITC CSB-PA643571LC01HU AAK1 Antibody, FITC conjugated
    Biotin CSB-PA643571LD01HU AAK1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Preferentially, may phosphorylate substrates on threonine residues. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.; (Microbial infection) By regulating clathrin-mediated endocytosis, AAK1 plays a role in the entry of hepatitis C virus as well as for the lifecycle of other viruses such as Ebola and Dengue.
  • 基因功能參考文獻(xiàn)：
    1. Results present the first structures of AAK1 and BIKE which reveal that all members of the Numb-associated kinase family share unusual activation segment architecture. PMID: 26853940
    2. Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis PMID: 25852190
    3. AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively. PMID: 25653444
    4. AAK1 increases the localization of activated Notch to Rab5-positive endocytic vesicles, while AAK1 depletion or overexpression of Numb, an inhibitor of the pathway, interferes with this localization. PMID: 21464124
    5. These observations suggest that AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome. PMID: 17494869

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Peripheral membrane protein. Membrane, clathrin-coated pit. Cell junction, synapse, presynapse.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Detected in brain, heart and liver. Isoform 1 is the predominant isoform in brain.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19679

    OMIM: 616405

    KEGG: hsa:22848

    STRING: 9606.ENSP00000386456

    UniGene: Hs.468878



主站蜘蛛池模板： 人妻精品久久久久中文字幕69| 毛片免费观看天天干天天爽| 成人免费无码不卡毛片视频| 日产精品久久久久久久蜜臀| 国产成人一区二区三区影院动漫| 玖玖资源站最稳定网址| 国产suv精二区| 玩弄少妇人妻中文字幕 | 少妇特黄a一区二区三区| 免费国产a国产片高清网站 | av第一福利网站| 亚洲欲色欲色xxxxx在线| 激情无码人妻又粗又大| 欧美人与动牲交zooz乌克兰| 无码超乳爆乳中文字幕久久| 亚洲国产日韩欧美综合a| 国内精品九九久久精品| 波多野结衣中文字幕久久| 亚州中文字幕无码中文字幕| 丰满无码人妻热妇无码区| 久久不见久久见免费视频7| 免费夜色污私人影院在线观看| 日韩经典精品无码一区| 国产av午夜精品一区二区三| 成人av无码一区二区三区 | 久久精品人人爽人人爽 | 亚洲女人色综合小说| 日本黄页网站免费大全| 亚洲国产aⅴ成人精品无吗 | 人人爽人人澡人人高潮| 国产精品久久人妻无码网站蜜臀 | 亚洲精品tv久久久久久久久j| 国产乱妇无码大片在线观看| 亚洲国产精品久久久久爰色欲| 精品国产福利一区二区| 亚洲精品无码ma在线观看| 色爱无码av综合区| 国产高潮流白浆免费观看| 黑人大战欲求不满人妻| 久久久日韩精品一区二区| 熟女俱乐部五十路六十路av|