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  4. VBP1 Monoclonal Antibody

VBP1 Monoclonal Antibody

  • 中文名稱：
    VBP1 Monoclonal Antibody
  • 貨號(hào)：
    CSB-MA160131
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western blotting analysis using VBP1 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with VBP1 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) VBP1 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
    VBP1
  • 別名：
    VBP1; VHL Binding Protein 1; PFDN3; PFD3; Von Hippel-Lindau Binding Protein 1; Prefoldin Subunit 3; HIBBJ46; VBP-1; Von Hippel-Lindau-Binding Protein 1; VHL-Binding Protein 1; Prefoldin 3
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human VBP1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    21E11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
  • 基因功能參考文獻(xiàn)：
    1. Data show that von Hippel-Lindau-binding protein 1 (VBP1) enhances the stability of von Hippel-Lindau tumor suppressor protein (pVHL) and facilitates pVHL-mediated ubiquitination of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha). PMID: 29121446
    2. VBP1 acts together with p97 to regulate hMSH4 degradation. PMID: 23964080
    3. binds to HIF-1 alpha and regulates the function of HIF-1 alpha PMID: 12613020
    4. VBP1 and cullin2/von Hippel-Lindau are required for proper HIV-1 expression at a step between integrase-dependent proviral integration into the host genome and transcription of viral genes PMID: 17698809
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
  • 蛋白家族：
    Prefoldin subunit alpha family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12662

    OMIM: 300133

    KEGG: hsa:7411

    STRING: 9606.ENSP00000286428

    UniGene: Hs.436803



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