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  4. TUBB2A Monoclonal Antibody

TUBB2A Monoclonal Antibody

  • 中文名稱：
    TUBB2A鼠單克隆抗體
  • 貨號：
    CSB-MA000312
  • 規格：
    ￥1090
  • 圖片：
    • 1) Input: Mouse Brain Tissue Lysate 2) IP product: IP dilute 1: 200 Western blot analysis: primary antibody : 1: 10000 Secondary antibody: Goat anti-Mouse IgG, Light chain specific (S003), 1: 5000
    • Western blot analysis of 1) Mouse Brain tissue, 2) Rat Brain tissue, diluted at 1:100000.
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA000312 TUBB2A單克隆抗體靶向β-微管蛋白2A（TUBB2A），該蛋白作為細胞骨架核心成分參與細胞形態維持、胞內運輸及有絲分裂等重要生物學過程，在神經發育和腫瘤微環境調控等領域具有重要研究價值。本產品采用雜交瘤技術制備，經ELISA、Western Blot和免疫沉淀（IP）嚴格驗證，可特異性識別小鼠、大鼠及人源樣本中的TUBB2A蛋白，適用于微管蛋白復合物分析、細胞周期研究及神經退行性疾病模型構建等科研場景。該抗體具備高親和力與特異性，為探索細胞骨架動態調控機制、神經元分化路徑及微管相關蛋白互作網絡提供可靠工具，助力細胞生物學、神經科學及腫瘤微管靶向治療等前沿領域的研究突破。
  • Uniprot No.：
  • 基因名：
  • 別名：
    TUBB2A antibody; TUBB2 antibody; Tubulin beta-2A chain antibody; Tubulin beta class IIa antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Mouse,Rat,Human
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    M, R, (H)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    28B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IP
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IP 1:200-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
  • 基因功能參考文獻：
    1. TUBB2A missense mutation is associated with arthrogryposis multiplex congenita, brain abnormalities, and severe developmental delay. PMID: 28840640
    2. study associates mutations in TUBB2A with the spectrum of "tubulinopathy" phenotypes PMID: 24702957
    3. This is the first study showing that paclitaxel neuropathy risk is influenced by polymorphisms regulating the expression of a beta-tubulin gene. PMID: 22718863
    4. Class II beta-tubulin may be very useful for immunohistochemical diagnosis of classical Hodgkin's lymphoma. PMID: 22449234
    5. Data suggest that the increased betaII- and betaIII-tubulin contributed significantly to the resistance phenotype. PMID: 22180309
    6. lack of mutations in early stage lung cancer PMID: 12209967
    7. Mutations of the beta-tubulin gene, which might be a contraindication for chemotherapy based on taxans, were very rare events in gastric cancer. PMID: 12861402

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  • 相關疾病：
    Cortical dysplasia, complex, with other brain malformations 5 (CDCBM5)
  • 亞細胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tubulin family
  • 組織特異性：
    High expression in brain, where it represents 30% of all beta-tubulins.
  • 數據庫鏈接：

    HGNC: 12412

    OMIM: 615101

    KEGG: hsa:7280

    STRING: 9606.ENSP00000369703

    UniGene: Hs.654543



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