在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RRM1 Monoclonal Antibody

  • 中文名稱:
    RRM1鼠單克隆抗體
  • 貨號:
    CSB-MA0205181A0m
  • 規格:
    ¥1320
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-MA0205181A0m in 30μg/ml dilute concentrations.
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-MA0205181A0m in 30μg/ml dilute concentrations.
  • 其他:

產品詳情

  • 產品描述:
    RRM1單克隆抗體(CUSABIO貨號:CSB-MA0205181A0m)是針對核糖核苷酸還原酶M1亞基(RRM1)研發的高特異性科研工具,該靶點作為DNA合成與損傷修復的關鍵調控酶,在細胞周期調控及腫瘤化療耐藥性研究中具有重要價值。本產品采用雜交瘤技術制備,經嚴格的質控驗證,適用于人類樣本的ELISA和免疫組化(IHC)檢測,能夠精準識別內源性RRM1蛋白的表達定位。在基礎研究領域,該抗體可廣泛應用于腫瘤發生機制探索、化療藥物敏感性研究以及DNA代謝相關信號通路分析,特別適用于非小細胞肺癌、卵巢癌等實體瘤研究中RRM1蛋白表達水平的定量與定性檢測。其高親和力特性確保在復雜樣本基質中仍能保持優異的檢測靈敏度,為揭示RRM1在腫瘤微環境調控、基因組穩定性維持等前沿課題提供可靠技術支撐。通過優化抗原表位選擇及純化工藝,本產品在組織切片染色和蛋白免疫分析中展現出高度一致性,是癌癥分子生物學研究和轉化醫學實驗的理想選擇。
  • 產品名稱:
    mouse anti-Homo sapiens (Human) RRM1 monoclonal antibody
  • Uniprot No.:
  • 基因名:
    RRM1
  • 別名:
    R1 antibody; Ribonucleoside diphosphate reductase large subunit antibody; Ribonucleoside diphosphate reductase M1 chain antibody; Ribonucleoside diphosphate reductase subunit M1 antibody; Ribonucleoside reductase; large subunit antibody; Ribonucleoside-diphosphate reductase large subunit antibody; Ribonucleoside-diphosphate reductase subunit M1 antibody; Ribonucleotide reductase large chain antibody; Ribonucleotide reductase large subunit antibody; Ribonucleotide reductase M1 antibody; Ribonucleotide reductase M1 polypeptide antibody; Ribonucleotide reductase R1 subunit antibody; Ribonucleotide reductase; M1 subunit antibody; RIR 1 antibody; RIR1 antibody; RIR1_HUMAN antibody; RR 1 antibody; RR1 antibody; RRM 1 antibody; RRM1 antibody
  • 宿主:
    mouse
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human RRM1 Protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    monoclonal
  • 純化方式:
    >95%,protein G purifed
  • 克隆號:
    3D6H5
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  • 基因功能參考文獻:
    1. The evaluation of RRM1 gene expression in cfRNA allows for estimation of the risk of severe oral mucositis (OM) in patients subjected to radiotherapy PMID: 29865035
    2. The expression of RRM1 can be considered a predictor of poor survival in patients with pancreatic cancer receiving gemcitabine chemotherapy. PMID: 29214667
    3. Our results therefore demonstrate that RRM1 is a novel therapeutic target in multiple myeloma in the preclinical setting and provide the basis for clinical evaluation of RRM1 inhibitor, alone or in combination with DNA-damaging agents, to improve patient outcome in multiple myeloma PMID: 28442502
    4. three SNPs (corepressor interacting with RBPJ 1 (CIR1) rs13009079T>C, ribonucleotide reductase M1 (RRM1) rs1465952T>C and solute carrier family 38, member 4 (SLC38A4) rs2429467C>T), may play a role in the pathogenesis of lung cancer PMID: 27587543
    5. TP53 mutant cancer cells had elevation of ribonucleotide reductase subunit 1 (RRM1) and 2 (RRM2), which was reduced by inhibition of mTORC1. PMID: 28507282
    6. The genetic polymorphisms RRM1 -756T>C and -269C>A may not be a factor for susceptibility to cervical neoplasia PMID: 27179014
    7. Based on the results of clinical trials, we conclude that Ribonucleotide reductase (RR) enzymes (RR1 and RR2)inhibitors are viable treatment options, either as a monotherapy or as a combination in cancer chemotherapy. With the recent advances made in cancer biology, further development of RR inhibitors with improved efficacy and reduced toxicity is possible for treatment of variety of cancers. PMID: 28624910
    8. RRM1 single nucleotide polymorphism is associated with Non-Small-Cell Lung Cancer. PMID: 27908619
    9. RRM1/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1/RRM2 in order to preserve ongoing replication and avoid the accumulation of DNA damage in hypoxic cells. PMID: 28416140
    10. findings suggest that the up-regulated RRM1 and hTrx1 in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy. PMID: 28411237
    11. RRM1 and ERCC1 expression levels did not show any relationship with overall survival. PMID: 26612755
    12. RRM1 and ERCC wild type alleles are risk-reducing factor for Coronary artery disease (CAD). Also, carrying RRM1 A allele might have a protective effect for smokers. PMID: 27566080
    13. Presence of rare AA (-37C>A) and CC (-524C>T) genotypes of the RRM1 may be favorable predictive factors for chemotherapy with platinum compounds and gemcitabine in non-small cell lung cancer patients. PMID: 26650486
    14. study finds that ERCC1 and RRM1 are not independent prognostic factors of recurrence in stage I non-small cell lung cancer patients PMID: 26542178
    15. mRNA expression of RRM1 was closely associated with cell proliferation and varied in seven non-Hodgkin lymphoma cell lines. PMID: 27173327
    16. A significant association has been found between RRM1 rs12806698 (-269C>A) RRM1 genotype and the risk for developing non-small cell lung cancer. PMID: 26718430
    17. Results underline the relevance of microRNA-101-3p-driven regulation of RRM1 in pancreatic ductal carcinoma gemcitabine resistance. PMID: 26828016
    18. The genotype of ribonucleotidereductase M1 -269C > A is associated with the response to platinum-based chemotherapy and as a prognostic biomarker in advanced nonsmall cell lung cancer PMID: 26323924
    19. TUBB3, TOP2A, CYP19A1 and CYP2D6 gene expression, but not protein expression, was associated with patient survival. PMID: 26252353
    20. A possible predictive impact of ribonucleotide-reductase subunit-1 (RRM1) on vinorelbine efficacy in non-small cell lung cancer (NSCLC) has been previously reported. PMID: 26637889
    21. RRM1 expression was predictive and prognostic of clinical outcome in advanced UC treated with gemcitabine plus platinum combination chemotherapy PMID: 26200905
    22. RNA expression of deoxycytidine kinase (DCK), human equilibrative nucleoside transporter-1 (ENT1) and ribonucleotide reductase M1 (RRM1) were significantly higher and cytidine deaminase (CDA) was significantly lower in ex vivo Ara-C sensitive samples. PMID: 26083014
    23. It is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells. PMID: 25837929
    24. For RRM1 C37A-T524C genotype, sensitive group had higher proportion of high effective genotype than non-sensitive group (p=0.009). PMID: 26028097
    25. Adenoviral vector expressing short hairpin RNA targeting RRM1 exerts potent antitumor effects and increases sensitivity to gemcitabine. PMID: 26254808
    26. Data demonstrate that RRM1 gene interferes with mitotane metabolism in adrenocortical cancer cells, as a possible mechanisms of drug resistance. PMID: 25497672
    27. These in vitro results suggest that mRNA expression levels of the RRM1 and ABCB1 genes may be useful indicators of chemosensitivity to gemcitabine and cisplatin. PMID: 25560468
    28. The oligomerization-directed fluorescence quenching of hRNR-alpha, covalently labeled with two fluorophores, allows for direct readout of hRNR dimeric and hexameric states. PMID: 25256246
    29. RRM1 expression was identified as independent prognosticators for freedom from recurrence of malignant pleural mesothelioma in patients undergoing induction chemotherapy followed by extrapleural pneumonectomy. PMID: 25840756
    30. In Turkish population RRM1 rs12806698 carriers have nearly twofold risk for development of head and neck squamous epithelial cell cancer. PMID: 24861915
    31. Patients with high RRM1 expression benefited more from a platinum-containing regimen, and patients with high BRCA1 expression showed a high response rate to a platinum-containing regimen and reduced disease progression. PMID: 25078585
    32. Gene polymorphisms of RRM1 -756T>C and RRM1 -269C>A may be not an important factor for the susceptibility of breast cancer. PMID: 24578158
    33. concomitant low expression levels of ERCC1, RRM1, and RRM2 and the high expression level of BRCA1 were predictive of a better outcome. PMID: 25227663
    34. RRM1 gene expression may contribute to chemotherapy sensitivity and may be an indicator of survival in nonsmall cell lung cancer patients treated with gemcitabine plus cisplatin. PMID: 24591771
    35. RRM1 IHC expression tailored selection of first-line therapy could improve therapeutic outcomes in patients with advanced NSCLC. PMID: 24595080
    36. High intratumoural hENT1 and low RRM1 expression were independently associated with prolonged disease-free survival in cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy. PMID: 25032731
    37. High RRM1 expression is associated with non-small cell lung cancer. PMID: 23803067
    38. No change in RRM1 expression was observed in primary NSCLC tumours, but expression seemed to be higher in N2 lymph node metastases following chemotherapy. PMID: 24266856
    39. Ribonucleotide reductase large subunit M1 predicts poor survival due to modulation of proliferative and invasive ability of gastric cancer. PMID: 23922955
    40. we found no support of the hypothesis that aberrations of RRM1 or RRM2B, neither individually nor in combination, are associated with an altered clinical outcome following chemotherapy. PMID: 24215511
    41. We observed an increase of ORR in NSCLC patients when they were treated with chemotherapy according to ERCC1 and RRM1 SNPs status. PMID: 24045016
    42. low expression of RRM1 and RRM2 could be used to predict the treatment response to platinum-based chemotherapy and survival in non-small cell lung cancer PMID: 24155212
    43. RRM1 preserves chromosomal stability via the CHK1- and CDK1-dependent stabilization of the centrosomal integrity at the replication stage. PMID: 24434653
    44. Genetic polymorphisms in SLC28A3, SLC29A1 and RRM1 can influence the clinical outcome of metastatic breast cancer patients treated with paclitaxel-gemcitabine chemotherapy. PMID: 24361227
    45. The analysis of RRM1 (-37C>A) more than ERCC1 (19007C>T) polymorphism may be a promising tool in the qualification of NSCLC patients for chemotherapy containing platinum compounds and gemcitabine PMID: 23982437
    46. These results suggest that SNPs within ribonucleotide reductase (RRM1 and RRM2) might be helpful predictive markers of response to nucleoside analogs and should be further validated in larger cohorts. PMID: 24024897
    47. Low RRM1 expression is associated with response to therapy in pancreatic cancer. PMID: 23991987
    48. RR1 expression may discriminate cervical cancer phenotype and radiochemotherapy outcome PMID: 23552804
    49. The expressions of MDR-1, RRM-1, EGFR, ERCC-1 were observed in a variety of pathological types of NSCLC. PMID: 23948418
    50. Report essential roles for ribonucleotide reductase and thymidylate synthase in C-MYC-dependent suppression of senescence in melanoma cells. PMID: 23249808

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Ribonucleoside diphosphate reductase large chain family
  • 數據庫鏈接:

    HGNC: 10451

    OMIM: 180410

    KEGG: hsa:6240

    STRING: 9606.ENSP00000300738

    UniGene: Hs.445705



主站蜘蛛池模板: 精品国产一区二区三区香蕉| 国产美女精品视频线免费播放| 成熟妇人a片免费看网站| 中国女人内谢69xxxx| 天天做天天大爽天天爱| 少妇精品偷拍高潮少妇小说| 奇米影视7777久久精品人人爽| 激情五月婷婷| 国产精品无码av无码| 亚洲欧洲自拍拍偷精品网| 国内精品久久人妻互换 | 夫妇交换性三中文字幕| 十八岁污网站在线观看| 国产xxxx色视频在线观看| 国产女人乱子对白av片| www国产精品内射熟女| 亚洲精品国产字幕久久不卡| 精品亚洲成a人片在线观看| 欧美xxxx做受欧美88| 欧美日韩欧美| 欧美成 人版中文字幕| 亚洲最大成人网 色香蕉| 欧美极品少妇无套实战| 精品人妻无码一区二区三区换脸| 亚洲色成人网站永久| 五月天天天综合精品无码| 无码日韩精品一区二区人妻| 久久中文字幕人妻av熟女| 999久久久精品国产消防器材| 免费国产裸体美女视频全黄| 亚洲国产成人精品无码区99| 精品国产一区二区三区麻豆| 综合偷自拍亚洲乱中文字幕| 国产9色在线 | 日韩| 丰满岳乱妇在线观看中字| 国内免费视频成人精品| 国产成人av一区二区三区在线观看| 鲁一鲁一鲁一鲁一澡| 国产在线午夜不卡精品影院| 人妻熟妇乱又伦精品视频| 日韩国产成人精品视频|