在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. Phospho-Histone H3(Ser28) Monoclonal Antibody

Phospho-Histone H3(Ser28) Monoclonal Antibody

  • 中文名稱：
    磷酸化-組蛋白H3(Ser28)鼠單克隆抗體
  • 貨號：
    CSB-MA010418PA28ph02HU
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing Hela cells stained with CSB-MA010418PA28ph02HU (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
    • Overlay Peak curve showing HepG2 cells stained with CSB-MA010418PA28ph02HU (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • 產品描述：
    Phospho-Histone H3(Ser28) Monoclonal Antibody（CUSABIO貨號：CSB-MA010418PA28ph02HU）是針對人類HIST1H3A蛋白Ser28位點磷酸化修飾研發的高特異性單克隆抗體，適用于酶聯免疫吸附實驗（ELISA）和流式細胞術（FC）等科研檢測。H3組蛋白作為染色質結構核心組分，其Ser28位點的磷酸化修飾是細胞周期調控的關鍵標志物，尤其在染色體凝聚和有絲分裂進程中發揮重要作用。該抗體基于雜交瘤技術制備，具有嚴格的物種特異性（Human），能夠精準識別磷酸化修飾位點，為細胞周期動力學研究、腫瘤細胞增殖活性檢測及表觀遺傳調控機制探索提供可靠工具。其應用場景涵蓋基礎科研中的有絲分裂進程監測、癌癥相關信號通路分析以及藥物開發中的細胞增殖抑制評估，是研究細胞分裂與基因組穩定性的重要分子探針。通過優化抗體純化工藝，該產品在保證高親和力的同時有效降低非特異性結合，適用于復雜樣本體系的定量與定性分析。
  • 產品名稱：
    Mouse anti-Homo sapiens (Human) HIST1H3A Monoclonal Antibody antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l), HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J, H3FA, H3FL, H3FC, H3FB, H3FD, H3FI, H3FH, H3FK, H3FF, H3FJ
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal Antibody
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%, Protein G purified
  • 克隆號：
    3F12A10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
  • 基因功能參考文獻：
    1. Data indicate the mechanism for epigenetic regulation in cancer by inducing E3 ubiquitin ligase NEDD4-dependent histone H3 ubiquitination. PMID: 28300060
    2. the identification of increased expression of H3K27me3 during a patient's clinical course can be helpful for determining whether the tumors are heterochronous PMID: 29482987
    3. Here, we report that JMJD5, a Jumonji C (JmjC) domain-containing protein, is a Cathepsin L-type protease that mediates histone H3 N-tail proteolytic cleavage under stress conditions that cause a DNA damage response. PMID: 28982940
    4. Data suggest that Ki-67 antigen proliferative index has important limitations and hhosphohistone H3 (PHH3) is an alternative proliferative marker. PMID: 29040195
    5. These results identify cytokine-induced histone 3 lysine 27 trimethylation as a mechanism that stabilizes gene silencing in macrophages PMID: 27653678
    6. This data indicates that, in the early developing human brain, HIST1H3B constitutes the largest proportion of H3.1 transcripts among H3.1 isoforms. PMID: 27251074
    7. This series of 47 diffuse midline gliomas, histone H3-K27M mutation was mutually exclusive with IDH1-R132H mutation and EGFR amplification, rarely co-occurred with BRAF-V600E mutation, and was commonly associated with p53 overexpression, ATRX loss, and monosomy 10. Among these K27M+ diffuse midline gliomas. PMID: 26517431
    8. Data show that histone chaperone HIRA co-localizes with viral genomes, binds to incoming viral and deposits histone H3.3 onto these. PMID: 28981850
    9. These experiments showed that PHF13 binds specifically to DNA and to two types of histone H3 methyl tags (lysine 4-tri-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator. PMID: 27223324
    10. Hemi-methylated CpGs DNA recognition activates UHRF1 ubiquitylation towards multiple lysines on the H3 tail adjacent to the UHRF1 histone-binding site. PMID: 27595565
    11. We describe, for the first time, the MR imaging features of pediatric diffuse midline gliomas with histone H3 K27M mutation PMID: 28183840
    12. Approximately 30% of pediatric high grade gliomas (pedHGG) including GBM and DIPG harbor a lysine 27 mutation (K27M) in histone 3.3 (H3.3) which is correlated with poor outcome and was shown to influence EZH2 function. PMID: 27135271
    13. H3F3A K27M mutation in adult cerebellar HGG is not rare. PMID: 28547652
    14. Data show that lysyl oxidase-like 2 (LOXL2) is a histone modifier enzyme that removes trimethylated lysine 4 (K4) in histone H3 (H3K4me3) through an amino-oxidase reaction. PMID: 27735137
    15. Histone H3 lysine 9 (H3K9) acetylation was most prevalent when the Dbf4 transcription level was highest whereas the H3K9me3 level was greatest during and just after replication. PMID: 27341472
    16. SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. PMID: 27614073
    17. Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes. PMID: 28341809
    18. The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex. PMID: 27679476
    19. Histone H3 modifications caused by traffic-derived airborne particulate matter exposures in leukocytes PMID: 27918982
    20. A key role of persistent histone H3 serine 10 or serine 28 phosphorylation in chemical carcinogenesis through regulating gene transcription of DNA damage response genes PMID: 27996159
    21. hTERT promoter mutations are frequent in medulloblastoma and are associated with older patients, prone to recurrence and located in the right cerebellar hemisphere. On the other hand, histone 3 mutations do not seem to be present in medulloblastoma. PMID: 27694758
    22. AS1eRNA-driven DNA looping and activating histone modifications promote the expression of DHRS4-AS1 to economically control the DHRS4 gene cluster. PMID: 26864944
    23. Data suggest that nuclear antigen Sp100C is a multifaceted histone H3 methylation and phosphorylation sensor. PMID: 27129259
    24. The authors propose that histone H3 threonine 118 phosphorylation via Aurora-A alters the chromatin structure during specific phases of mitosis to promote timely condensin I and cohesin disassociation, which is essential for effective chromosome segregation. PMID: 26878753
    25. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its H3 histone recognition. PMID: 27045799
    26. Functional importance of H3K9me3 in hypoxia, apoptosis and repression of APAK. PMID: 25961932
    27. Taken together, the authors verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin. PMID: 26032366
    28. We conclude that circulating H3 levels correlate with mortality in sepsis patients and inversely correlate with antithrombin levels and platelet counts. PMID: 26232351
    29. Data show that double mutations on the residues in the interface (L325A/D328A) decreases the histone H3 H3K4me2/3 demethylation activity of lysine (K)-specific demethylase 5B (KDM5B). PMID: 24952722
    30. Data indicate that minichromosome maintenance protein 2 (MCM2) binding is not required for incorporation of histone H3.1-H4 into chromatin but is important for stability of H3.1-H4. PMID: 26167883
    31. Data suggest that histone H3 lysine methylation (H3K4me3) serves a crucial mechanistic role in leukemia stem cell (LSC) maintenance PMID: 26190263
    32. PIP5K1A modulates ribosomal RNA gene silencing through its interaction with histone H3 lysine 9 trimethylation and heterochromatin protein HP1-alpha. PMID: 26157143
    33. Data indicate that the lower-resolution mass spectrometry instruments can be utilized for histone post-translational modifications (PTMs) analysis. PMID: 25325711
    34. Data indicate that inhibition of lysine-specific demethylase 1 activity prevented IL-1beta-induced histone H3 lysine 9 (H3K9) demethylation at microsomal prostaglandin E synthase 1 (mPGES-1) promoter. PMID: 24886859
    35. The authors report that de novo CENP-A assembly and kinetochore formation on human centromeric alphoid DNA arrays is regulated by a histone H3K9 acetyl/methyl balance. PMID: 22473132

    顯示更多

    收起更多

  • 相關疾病：
    Glioma (GLM)
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H3 family
  • 數據庫鏈接：

    HGNC: 4766

    OMIM: 137800

    KEGG: hsa:8350

    STRING: 9606.ENSP00000444823

    UniGene: Hs.132854



主站蜘蛛池模板： 久久成人国产精品免费| 亚洲 欧美 日韩 综合aⅴ| 噜噜色综合噜噜色噜噜色| 久久久橹橹橹久久久久高清| 亚洲精品第一国产综合国服瑶| 妺妺窝人体色www在线观看| 久久久久久av无码免费看大片| 欧美丰满熟妇hdxx| 一本一本久久a久久综合精品蜜桃 国产精品人妻久久毛片高清无卡 成视频年人黄网站视频福利 | 成人欧美日韩一区二区三区| 香港日本三级亚洲三级 | 无码精品一区二区三区免费视频| 色婷婷香蕉在线一区二区| 美女张开腿黄网站免费| 精品国产无套在线观看| 久久国产午夜精品理论片34页| 99久久国产综合精品成人影院| 美女内射毛片在线看免费人动物| 久久国产成人免费网站777| 久久婷婷六月综合色液啪| 日日摸日日碰夜夜爽无| 97精品国产97久久久久久免费| 男女高潮又爽又黄又无遮挡| 国产成人av免费网址| 亚洲欧美人成电影在线观看| 天堂中文在线www天堂在线| 色av综合av综合无码网站| 中文乱码人妻系列一区| 久久亚洲精品人成综合网| 人妻一本久道久久综合久久鬼色| 特级做a爰片毛片免费看108| 亚洲欧美综合国产精品二区| 动漫无遮挡h纯肉亚洲资源大片| 欧美大胆少妇bbw| 精品国产免费一区二区三区 | 中文字幕一区二区人妻电影| 中文字幕av伊人av无码av狼人| 成人无码α片在线观看不卡 | 柠檬福利精品视频导航| 国产成人无码av在线播放不卡| 亚洲熟女综合色一区二区三区|