在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

PGR Monoclonal Antibody

  • 中文名稱:
    PGR鼠單克隆抗體
  • 貨號:
    CSB-MA080142
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human breast caricnoma using PR Monoclonal Antibody.
  • 其他:

產品詳情

  • 產品描述:
    CUSABIO貨號:CSB-MA080142 PGR單克隆抗體是針對孕酮受體(Progesterone Receptor)研發的高特異性科研試劑,該靶標蛋白在調節生殖系統功能、乳腺發育及中樞神經活動中發揮關鍵作用,其表達水平與子宮內膜異位癥、乳腺癌等疾病的病理機制密切相關。本產品采用雜交瘤技術制備,經嚴格驗證可特異性識別人類、小鼠及大鼠樣本中的PGR蛋白,適用于ELISA免疫分析、免疫組化(IHC)組織定位及免疫熒光(IF)細胞成像等多維實驗場景??蒲腥藛T可借助該抗體精準檢測不同物種模型中PGR蛋白的表達分布與動態變化,為生殖生物學研究、婦科腫瘤機制探索以及神經內分泌調控實驗提供可靠工具。該PGR抗體具有高批次穩定性和低交叉反應特性,特別適用于構建生殖系統疾病動物模型、乳腺癌細胞信號通路研究及神經保護機制分析等前沿領域,滿足分子生物學、病理學等多學科交叉研究的實驗需求。
  • Uniprot No.:
  • 基因名:
  • 別名:
    NR3C3 antibody; Nuclear receptor subfamily 3 group C member 3 antibody; PGR antibody; PR antibody; PRA antibody; PRB antibody; PRGR_HUMAN antibody; Progesterone receptor antibody; Progestin receptor form A antibody; Progestin receptor form B antibody
  • 宿主:
    Mouse
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic Peptide
  • 免疫原種屬:
    Human, Mouse, Rat
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 克隆號:
    3G5
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:200
    IF 1:100-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.; Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.; Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.; Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
  • 基因功能參考文獻:
    1. We found that the Alu insertion was associated with breast cancer incidence in Indians and Indo-European mixed racial groups, but the association disappeared for patients of Caucasian or Latino decent. Our meta-analysis showed that the Alu-insertion progesterone receptor gene polymorphism was not associated with breast cancer. [Meta-analysis] PMID: 29370776
    2. findings showed no association between PROGINS and leiomyoma in the overall analysis nor in either of the subgroups, Asian or non-Asian, in all genetic models;. conclusion: The PROGINS polymorphisms cannot be considered a risk factor for developing uterine leiomyoma - Systematic Review and Meta-Analysis PMID: 29630404
    3. in primary breast tumors, PR-A expression was correlated negatively with miR-92a-3p expression and positively with miR-26b-5p expression. Therefore, hormonal cross-talk of PR-A with ER is probably a fundamental mechanism that enables metastasis of luminal breast cancer. PMID: 29162724
    4. heterogeneous distribution in deep infiltrating endometriosis PMID: 29383962
    5. This study aimed to determine the presence and localization of oestrogen receptors (ERs), progesterone receptors (PRs), and androgen receptors (ARs) in both healthy and varicose vein wall cells and their relationship with gender. PMID: 30250632
    6. These findings suggest that in myometrial cells the repressive activity of PR-A on PR-B increases with advancing gestation and is induced by pro-inflammatory cytokines. PMID: 28671036
    7. polymorphisms do not predict in vitro fertilization outcome PMID: 29916276
    8. Data show that insulin-like growth factor-II mRNA-binding protein 2 and 3 (IMP2/3)-miR-200a-progesterone receptor axis represents a double-negative feedback loop and serves as a new potential therapeutic target for the treatment of Triple-negative breast cancer (TNBC). PMID: 29217458
    9. The experimental data corroborated the inhibitory function of miR-513a-5p on progesterone receptor expression in breast cancer confirming that progesterone receptor is a target of miR-513a-5p PMID: 29126102
    10. A major finding of our study is that one out of five (20%) patients with breast cancer BM had a receptor discrepancy between the primary tumor and the subsequent BM, with loss of hormone receptors (ER and/or PR) expression, and gain of HER2 overexpression as the most commonly observed changes PMID: 28975433
    11. Single nucleotide polymorphism in progesterone receptor gene is associated with the risk of type 2 diabetes among Hispanic Americans compared to European American postmenopausal women. PMID: 29417738
    12. In progesterone control of myometrial contractility during pregnancy and labour, while liganded nuclear progesterone receptor B can suppress the expression of Cx43, unliganded progesterone receptor A paradoxically translocates to the nucleus where it acts as a transcriptional activator of this labour gene. PMID: 27220952
    13. Progesterone receptor, EGFR, and galectin-3 are expressed differentially in uterine smooth muscle tumors. PMID: 29729689
    14. Estrogen receptor (ER) and progesterone receptor (PR) expression in endometrial carcinoma (EC) were significantly higher than those in the paracarcinoma tissue and control. PMID: 29081408
    15. Alcohol consumption may have differential effects on concordant and discordant receptor subtypes of breast cancer. PMID: 29353824
    16. General obesity, indicated by BMI, is more strongly associated with ER+/PR+ subtype, especially among premenopausal women, whereas central obesity, indicated by WHR, is more specific for ER-/PR- subtype, independent of menopausal status. These results suggest that different chemoprevention strategies may be appropriate in selected individuals. PMID: 28912152
    17. TIMP-3 mRNA expression levels positively correlates with levels of miR-21 in in situ breast carcinomas and negatively in progesterone receptor positive invasive breast carcinomas. PMID: 28935174
    18. results suggest differential downstream progesterone receptor signalling, as progesterone receptor regulates MMP3/10 expression via HIF1A, which is not involved in ADAMTS-1 expression PMID: 28736153
    19. Association of progesterone receptor gene polymorphism with threatened abortion. PMID: 29762972
    20. Villin, Pro-Ex-C and progesterone/estrogen receptor expression have diagnostic and predictive roles in endocervical and endometrioid adenocarcinoma. PMID: 28832070
    21. These data collectively indicate that progesterone suppresses triple-negative breast cancer (TNBC) growth and metastasis via mPRalpha, which provides evidence of the anti-neoplastic effects of progesterone-mPRalpha pathway in the treatment of human TNBC. PMID: 28713912
    22. Patients with Estrogen- and progesterone receptors-positive invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC)have similar quantitative ER and PR expression profiles, implicating that ER/PR expression is unlikely to be a confounding factor in studies concerning chemo-sensitivity of ILC and IDC PMID: 28365834
    23. The progesterone receptor B (PRB) and androgen Receptor (AR) mRNA levels were highest in tumors. PMID: 29491078
    24. Chorionic gonadotropin activates Epac-Erk1/Erk2 signaling regulating progesterone receptor expression and function in human endometrial stromal cells. PMID: 28333280
    25. Ten international pathology institutions participated in this study and determined messenger RNA expression levels of ERBB2, ESR1, PGR, and MKI67 in both centrally and locally extracted RNA from formalin-fixed, paraffin-embedded breast cancer specimens with the MammaTyper(R) test. Samples were measured repeatedly on different days within the local laboratories, and reproducibility was assessed by means of variance comp... PMID: 28490348
    26. Human myometrial tissue in culture undergoes changes in progesterone receptor (PR) gene expression consistent with transition toward a laboring phenotype. TSA maintained the nonlaboring PR isoform expression pattern. PMID: 28540297
    27. OHPg/PR-B through Beclin-1 and Bcl2 evoke autophagy-senescence transition in breast cancer cells PMID: 27462784
    28. Report a significant survival benefit in lung adenocarcinoma patients with positive expression of one of the investigated hormonal receptors: androgen receptor, estrogen receptor-alpha or progesterone receptor. PMID: 27690341
    29. We investigate the impact of central histology (n = 772), immunohistochemistry for intrinsic subtyping and IHC4, and dichotomous (GG) or continuous (GGI) genomic grade (n = 472) on patient outcome and benefit from taxane chemotherapy, focusing on HR+/HER2(HR: ER and/or PR)- patients (n = 459) PMID: 27022068
    30. progesterone receptor expression status correlates with final pregnancy outcome PMID: 27728856
    31. RA induced loss of PR binding only at the proximal site. Interestingly, RARalpha was recruited to the -1.1 kb PRE and the -130 bp PRE/RARE regions with P4, but not RA alone or RA plus P4 PMID: 28692043
    32. the 5alpha-reduction of progesterone decreased PR activation significantly, 16alpha-hydroxyprogesterone and 16OH-dihydroprogesterone exhibited comparable receptor activation. PMID: 27664517
    33. C/EBPbeta negatively regulates PR-B expression in glioblastoma cells. PMID: 27663075
    34. Evaluation of progesterone expression in axillary lymph node metastasis of ER-positive, HER2-negative breast cancer may enable prediction of patients who are less likely to benefit from adjuvant tamoxifen. PMID: 28416639
    35. Insight into previously reported associations between +331G/A polymorphism and breast cancer risk. [meta-analysis; review] PMID: 29084518
    36. findings suggest that GATAD2B serves as an important mediator of progesterone-progesterone receptor suppression of proinflammatory and contractile genes during pregnancy; decreased GATAD2B expression near term may contribute to the decline in progesterone receptor function, leading to labor PMID: 28576827
    37. The altered expression of ER and PR may be associated with the expression variation of integrin and pinopode formation in endometrium of luteal phase deficit women. PMID: 27960568
    38. We sought to determine the relation between 17-alpha hydroxyprogesterone caproate plasma concentrations, progesterone receptor single nucleotide polymorphisms and single nucleotide polymorphisms in CYP3A4 and CYP3A5 and spontaneous preterm birth. PMID: 28522317
    39. the estrogen- (ER), progesterone- (PgR) and HER2/neu receptor status of the primary tumor with brain metastases in a series of 24 consecutive breast cancer patients, is reported. PMID: 28870906
    40. we found that combinatorial MK-2206+progesterone treatments decreased angiogenesis and proliferation in the Pten(d/d) conditional mouse model of endometrial cancer. Taken together, these findings suggest that a combinatorial therapeutic approach utilizing Akt inhibitors with progestins may improve the efficacy of progestin therapy for the treatment of endometrial cancer. PMID: 26996671
    41. The interplay between intracellular progesterone receptor and PRKCA-PRKCD plays a key role in migration and invasion of human glioblastoma cells. PMID: 27717886
    42. Folic acid inhibits colon cancer cell proliferation through activation of PR. PMID: 27233474
    43. The endometrial expression of PR and Ki67 along with serum CA125 predicted the development of lymph node metastasis in endometrial cancer. PMID: 27163153
    44. Overexpression of RNA-binding region-containing protein 1 (RNPC1) increased, whereas knockdown of RNPC1 decreased, the level of progesterone receptor (PR) protein and transcripts. PMID: 27634883
    45. analysis of pancreatic adenocarcinoma reveals nPR and the presence of mPR of alpha, beta, gamma subtypes both at the mRNA and protein levels PMID: 27449817
    46. Working model. During most of pregnancy, progesterone via PR-B promotes myometrial cell quiescence in part by repressing responsiveness to proinflammatory stimuli. With advancing gestation, prolabor signals increase the inflammatory load on the uterus until a threshold is reached. The threshold is the point at which inflammatory stimuli augment PR-A stability. PMID: 27886516
    47. Choroidal metastases from BC are associated with ER and PR expression in the primary tumor and the luminal B molecular subtype. PMID: 27479811
    48. Data suggest the relevance of determining the progesterone receptor (PR) isoform ratio before starting antiprogestin treatments. PMID: 28376177
    49. The data show that human parturition involves the phosphorylation of PR-A at serine-345 in myometrial cells and that this process is ligand dependent and induced by a proinflammatory stimulus. PMID: 27653036
    50. PR-B expression was significantly reduced in the eutopic endometrium (p=0.031) and ovarian endometrioma (p=0.036) from women with advanced-stage endometriosis compared with eutopic endometrium tissues from control subjects. PMID: 27593876

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Note=Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane.
  • 蛋白家族:
    Nuclear hormone receptor family, NR3 subfamily
  • 組織特異性:
    In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of th
  • 數據庫鏈接:

    HGNC: 8910

    OMIM: 607311

    KEGG: hsa:5241

    STRING: 9606.ENSP00000325120

    UniGene: Hs.32405



主站蜘蛛池模板: 国产一区二区三区无码免费 | 欧美香蕉爽爽人人爽| 无码精品人妻一区二区三区av| 欧美群妇大交群| 18禁白丝喷水视频www视频| 在线欧美日韩制服国产| 国产成人精品一区二区不卡| 欧美无人区码suv| 人妻体体内射精一区二区| 成年片色大黄全免费软件到| 一本aⅴ高清一区二区三区| 欧洲精品一线二线三线区别| 麻豆精品一区二区综合av| 在线看片免费人成视频福利| 中文成人无码精品久久久动漫 | 午夜无码福利伦利理免| 717影院理论午夜伦八戒| 国产精品成人av片免费看| 日本高清视频www| 日韩69永久免费视频| 欧美中日韩免费观看网站| 午夜精品久久久久久中宇| 女人被狂爆到高潮免费视频 | 色琪琪丁香婷婷综合久久| 成年女人免费视频播放体验区| 99蜜桃在线观看免费视频网站| 97人妻免费公开在线视频| 麻花传媒mv国产免费观看视频| 影音先锋人妻啪啪av资源网站 | 久久精品国产亚洲欧美| 国产午夜鲁丝片av无码| 一本一本久久aa综合精品| 国产综合精品久久丫| 奇米影视色777四色在线首页| 午夜不卡av免费| 亚洲第一成人网站在线播放| 国产超碰人人做人人爽av动图| 柠檬福利第一导航在线| 和岳每晚弄的高潮嗷嗷叫视频| 国产精品久久久久7777按摩| av片在线观看永久免费|