MYCBP Monoclonal Antibody
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中文名稱：MYCBP鼠單克隆抗體
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貨號(hào)：CSB-MA8587101A0m
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規(guī)格：￥1320
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圖片：
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Immunohistochemical of paraffin-embedded Human testis tissue using CSB-MA8587101A0m at dilution of 1:200.
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其他：
產(chǎn)品詳情
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產(chǎn)品描述：MYCBP單克隆抗體（CUSABIO貨號(hào)：CSB-MA8587101A0m）是針對(duì)MYC結(jié)合蛋白（MYCBP）研發(fā)的高特異性科研試劑，該靶點(diǎn)作為MYC原癌基因的關(guān)鍵互作蛋白，在細(xì)胞周期調(diào)控、DNA損傷修復(fù)及腫瘤發(fā)生機(jī)制中具有重要研究?jī)r(jià)值。本產(chǎn)品采用雜交瘤技術(shù)制備，經(jīng)ELISA與免疫組化（IHC）雙平臺(tái)驗(yàn)證，可精準(zhǔn)識(shí)別人類來(lái)源的MYCBP抗原表位，適用于腫瘤生物學(xué)、分子病理學(xué)等領(lǐng)域的蛋白質(zhì)相互作用研究。科研人員可將其應(yīng)用于腫瘤組織切片中MYCBP蛋白的定位分析、體外培養(yǎng)細(xì)胞模型的蛋白表達(dá)水平檢測(cè)，以及基于ELISA平臺(tái)的定量分析實(shí)驗(yàn)。產(chǎn)品經(jīng)過(guò)嚴(yán)格的質(zhì)控流程，為探索MYC信號(hào)通路在腫瘤微環(huán)境調(diào)控、耐藥機(jī)制等前沿課題提供可靠工具。該抗體已成功應(yīng)用于乳腺癌、結(jié)直腸癌等實(shí)體瘤研究的文獻(xiàn)報(bào)道中，是癌癥標(biāo)志物篩選和分子機(jī)理研究的優(yōu)選試劑。
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產(chǎn)品名稱：mouse anti-Homo sapiens (Human) MYCBP monoclonal antibody
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Uniprot No.：
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基因名：MYCBP
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別名：AMY 1 antibody; AMY-1 antibody; AMY1 antibody; Associate of Myc 1 antibody; C myc binding protein antibody; C-Myc-binding protein antibody; Cmyc binding protein antibody; MYCBP antibody; MYCBP_HUMAN antibody
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宿主：mouse
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反應(yīng)種屬：Human
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免疫原：Recombinant Human MYCBP Protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：monoclonal
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純化方式：>95%,protein G purifed
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克隆號(hào)：1D5D5
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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產(chǎn)品提供形式：liquid
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應(yīng)用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:500 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
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基因功能參考文獻(xiàn)：
- c-Myc expression is reduced in pterygium compared with normal conjunctiva. PMID: 22050566
- Suppression of telomerase activity mediated by PinX1 is involved in the Mad1/c-Myc pathway. PMID: 20544396
- miR-22 acts as a tumor suppressor through direct repression of MYCBP expression and subsequent reduction of oncogenic c-Myc activities. PMID: 20562918
- identified a novel AMY-1-binding protein, AAT-1, and determied its expression profiles, genes, and cellular localization; results showed that AAT-1 was specifically expressed in the testis throughout spermatogenesis and was also present in mature sperm PMID: 12223483
- interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits enzyme acdtivity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex PMID: 12414807
- AMY-1 coordinates ADP-Ribosylation Factors-mediated membrane trafficking and signaling pathways. PMID: 16866877
- An important role for MBP-1 in the altered cell proliferation and energy utilization that occur in response to an altered glucose concentration. PMID: 17595061
- AMY-1 was localized in the mitochondria of HeLa and sperm in association with AKAP149 and S-AKAP84, respectively. These results suggest that AMY-1 plays a role in spermatogenesis PMID: 11483602
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亞細(xì)胞定位：Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
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蛋白家族：AMY1 family
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組織特異性：Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
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數(shù)據(jù)庫(kù)鏈接：
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