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  4. MAGEA4 Monoclonal Antibody

MAGEA4 Monoclonal Antibody

  • 中文名稱：
    MAGEA4鼠單克隆抗體
  • 貨號：
    CSB-MA013330A0m
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-MA013330A0m diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-MA013330A0m diluted at 1:200 and staining in paraffin-embedded human bladder cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-MA013330A0m diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-MA013330A0m diluted at 1:200 and staining in paraffin-embedded human gastric cancer tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing A375 cells stained with CSB-MA013331A0m (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA013330A0m MAGEA4單克隆抗體是靶向人類黑色素瘤相關抗原4（Melanoma-Associated Antigen A4）的高特異性科研試劑，該抗原屬于MAGE家族成員，在多種惡性腫瘤中呈現特異性高表達特征，是腫瘤免疫治療研究的重要靶點。本產品采用雜交瘤技術制備，經親和層析純化確保高純度，適用于ELISA、免疫組化（IHC）和流式細胞術（FC）等實驗平臺，可精準檢測人類樣本中MAGEA4蛋白的表達水平。其在腫瘤微環境研究、免疫檢查點調控機制探索及癌癥生物標志物篩選中具有重要價值，特別適用于黑色素瘤、肺癌、頭頸癌等實體腫瘤的體外實驗研究，為開發新型免疫療法提供可靠工具。該抗體經過嚴格質控驗證，具備優異的批間穩定性和抗原結合活性，支持多種實驗體系的蛋白定位與定量分析，是腫瘤免疫學研究和轉化醫學研究的關鍵試劑。
  • 產品名稱：
    Mouse anti-Homo sapiens (Human) MAGEA4 Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cancer/testis antigen 1.4 antibody; CT1.4 antibody; MAGA4_HUMAN antibody; MAGE 4 antibody; MAGE 4 antigen antibody; MAGE 41 antibody; MAGE 41 antigen antibody; MAGE 4A antibody; MAGE 4B antibody; MAGE X2 antibody; MAGE X2 antigen antibody; MAGE-4 antigen antibody; MAGE-41 antigen antibody; MAGE-X2 antigen antibody; MAGE4 antibody; MAGE41 antibody; MAGE4A antibody; MAGE4B antibody; MAGEA 4 antibody; MAGEA4 antibody; Melanoma antigen family A 4 antibody; Melanoma associated antigen 4 antibody; Melanoma-associated antigen 4 antibody; MGC21336 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Melanoma-associated antigen 4 protein (1-317AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%, Protein G purified
  • 克隆號：
    1G10H5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC：1:200-1:500
    FC FC：1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
  • 基因功能參考文獻：
    1. MAGEA4 was positively correlated with TWIST1, and its knockdown inhibited EMT in TE3 cells. PMID: 28653599
    2. Because of the significant correlation of MAGEA4 and indices of poor prognosis, the role of this CTA may be confirmed in Esophageal squamous cell carcinoma (ESCC) aggressiveness and metastasis. Therefore, MAGEA4 may be a promising therapeutic candidate for suppressing ESCC aggressiveness PMID: 30197348
    3. Study shows that whereas MAGEA4 expression by itself may be indicative of a poor prognosis in primary lung cancer, its prognostic value depends entirely on its subcellular localization and on the p53 status. The accumulation of nuclear MAGEA4 expression without p53 expression is significantly associated with poor survival, implying that MAGEA4 inhibits apoptosis and increases tumorigenesis. PMID: 29901069
    4. MAGE-A4 depletion from MAGE-A4-expressing cancer cells destabilizes RAD18. PMID: 27377895
    5. Our results support...the potential utility of MAGEA4 as an ancillary diagnostic marker for synovial sarcoma PMID: 28744588
    6. some autoantibodies, such as anti-MAGEA4, anti-CTAG1 or anti-TP53 and their combinations could possibly contribute to the development of cancer early detection tests (not necessarily restricted to gastric cancer) when being combined with other markers. PMID: 27140836
    7. Anti-MAGEA4 exhibited the highest sensitivity for detecting early stage colorectal cancer (CRC) and advanced adenoma. PMID: 26909861
    8. High MAGE-A4 expression is associated with Lung Cancer. PMID: 27793776
    9. Results found concomitant overexpression of MAGEA4 and TWIST1 in esophageal squamous cell carcinoma (ESCC). Also, it showed a correlation between MAGEA4 and TWIST1 expression, which was found as indirect binding of TWIST1 to the E-boxes in the MAGEA4 promoter revealing transcriptional upregulation of MAGEA4 by TWIST1. PMID: 27533647
    10. Results support the potential utility of NY-ESO-1, PRAME, and MAGEA4 as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas. PMID: 27993576
    11. CTAs (MAGE-A4, NY-ESO-1, MAGE-A10) were more likely expressed in patients with squamous cell carcinoma of the lung and when CTAs combined with CD133, they can be better prognostic factors. PMID: 26191258
    12. HLA class I loss in smokers or patients with the MAGE-A4 gene was a prognostic factors in non-small cell lung cancer . PMID: 23124547
    13. Expression of MAGE-A4 may make immunotherapeutic intervention possible in selected patients with thyroid cancer. PMID: 24238058
    14. Detection of MAGE-4 transcripts in blood may help to predict the prognosis and monitoring of the response of HCV-infected hepatocellular carcinoma patients to therapy PMID: 22653756
    15. Mage-A4 expression and serum identification is and potential therapeutic target in estrogen receptor negative breast cancer. PMID: 23172894
    16. MAGEA4 promotes growth by preventing cell cycle arrest and by inhibiting apoptosis mediated by the p53 transcriptional targets. PMID: 22842486
    17. High MAGE-4 gene expression is associated with metastases in hepatitis C virus patients complicated by hepatocellular carcinoma. PMID: 21452042
    18. MAGE-A4 is identified as a specific biomarker of esophageal squamous cell carcinoma with a possible oncogenic role contributing to tumor progression. PMID: 21613820
    19. novel HLA-A2-restricted T cell epitope derived from MAGE-4 was identified PMID: 21815906
    20. High MAGE-A4 gene expression is associated with head and neck squamous cell carcinoma PMID: 20715104
    21. Report immunohistochemical expression of MAGE-A4 in renal oncocytoma and chromophobe renal cell carcinoma. PMID: 20591578
    22. positive expression in patients with non-small cell lung cancer is associated with poorer overall survival PMID: 19545928
    23. MAGE-4 protein may have a role in development of hepatocellular carcinogenesis in cirrhotic patients PMID: 11985796
    24. MAGE-A4 expression in bladder transitional cell carcinoma. PMID: 12209610
    25. strong MAGE-A4 expression and to a lesser degree NY-ESO-1 expression is characteristic of the vast majority of uterine carcinosarcomas and a major subset of papillary serous carcinomas PMID: 12209997
    26. MAGE-A4 binds to gankyrin and suppresses its oncogenic activity. PMID: 12525503
    27. a cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis PMID: 14739298
    28. MAGE-A4(143-151) and SAGE(715-723) are HLA-A2402-restricted CTL epitopes PMID: 16061876
    29. Expression may represent potential targets for cancer immunotherapy in patients with non small cell lung carcinoma. PMID: 16596224
    30. Expressed in a large part of epithelial skin tumors with predominantly scattered immunoexpression pattern in organ-transplant recipients. PMID: 17214847
    31. Its expression is significantly associated with prognostic factors in poor outcome of the non-small cell lung cancer. PMID: 18982744
    32. Overexpression of MAGE-A4 is associated with bladder cancer. PMID: 19533752

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  • 組織特異性：
    Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
  • 數據庫鏈接：

    HGNC: 6802

    OMIM: 300175

    KEGG: hsa:4103

    STRING: 9606.ENSP00000276344

    UniGene: Hs.37107



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