在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LCN2 Monoclonal Antibody

  • 中文名稱:
    LCN2鼠單克隆抗體
  • 貨號:
    CSB-MA068302A0m
  • 規格:
    ¥1320
  • 圖片:
    • All lanes:Mouse anti-human Neutrophil gelatinase-associated lipocalin monoclonal antibody at 1μg/ml
      Lane 1:NGAL transfected 293 cell lysate
      Predicted band size : 22 kDa
      Observed band size : 25 kDa
    • Immunohistochemical of paraffin-embedded human spleen organization using CSB-MA068302A0m at dilution of 1:200
    • Immunohistochemical of paraffin-embedded human prostate tissue using CSB-MA068302A0m at dilution of 1:200
  • 其他:

產品詳情

  • 產品描述:
    LCN2單克隆抗體(CUSABIO貨號:CSB-MA068302A0m)是針對脂質運載蛋白-2(Lipocalin-2,LCN2)研發的高特異性科研試劑,適用于人類和小鼠樣本的多種實驗場景。LCN2作為先天免疫系統的關鍵調控因子,廣泛參與炎癥反應、鐵代謝調控及細胞凋亡等生物學過程,其異常表達與代謝綜合征、急性腎損傷及腫瘤微環境調控密切相關。本產品經嚴格驗證可兼容ELISA、Western Blot(WB)及免疫組化(IHC)三大實驗平臺,具有高親和力和批次穩定性,能精準識別LCN2蛋白的天然構象表位。在基礎科研領域,該抗體可助力研究者解析LCN2在非酒精性脂肪肝、敗血癥等疾病模型中的動態表達圖譜,或用于腫瘤微環境中免疫細胞互作機制的探究。其優異的種屬交叉反應性使其能同步支持轉基因小鼠模型與人類組織樣本的對比研究,為炎癥相關信號通路研究和生物標志物發現提供可靠工具。該產品嚴格遵循科研用途開發,滿足分子互作分析、蛋白定位及定量檢測等多元化實驗需求。
  • 產品名稱:
    mouse anti-Homo sapiens (Human) LCN2 monoclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    24p3 antibody; 25 kDa alpha 2 microglobulin related subunit of MMP9 antibody; 25 kDa alpha-2-microglobulin-related subunit of MMP-9 antibody; Alpha 2 microglobulin related protein antibody; HGNC:6526 antibody; HNL antibody; Lcn 2 antibody; Lcn2 antibody; Lipocalin-2 antibody; Migration stimulating factor inhibitor antibody; MSFI antibody; Neutrophil gelatinase associated lipocalin antibody; Neutrophil gelatinase associated lipocalin precursor antibody; Neutrophil gelatinase-associated lipocalin antibody; NGAL antibody; NGAL_HUMAN antibody; Oncogene 24p3 antibody; Oncogenic lipocalin 24p3 antibody; p25 antibody; Siderocalin antibody; siderocalin LCN2 antibody; SV40 induced 24P3 protein antibody; Uterocalin antibody
  • 宿主:
    mouse
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Recombinant Human Neutrophil gelatinase-associated lipocalin protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    monoclonal
  • 抗體亞型:
    IgG2b
  • 純化方式:
    >95%,Protein G purified
  • 克隆號:
    1A1B2
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
  • 基因功能參考文獻:
    1. NGAL is expressed in enteroendocrine cells in small intestine as well as in colon. PMID: 29869714
    2. Urinary NGAL levels were increased in type 2 diabetic patients with early diabetic nephropathy. PMID: 29673928
    3. In the second trimester, high urinary levels indicate tubular injury in gestational diabetes mellitus cases which seems to be a result of hyperglycemia PMID: 28768458
    4. use of bedside NGAL assessment may significantly hasten diagnosis and treatment of CI-AKI PMID: 29791495
    5. neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss of renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory renal diseases. PMID: 30078006
    6. Plasma NGAL is a valuable biomarker for differentiating between patients with asthma-chronic obstructive pulmonary disorder overlap and asthma patients. PMID: 29580282
    7. There is no significant relationship between breast cancer patients and LCN2 gene polymorphisms (rs11556770). PMID: 29915849
    8. Knockdown of NGAL protein exhibited inhibited proliferation, enhanced apoptosis, decreased expressions of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) as well as B-cell lymphoma-2 (Bcl-2) and increased expressions of cysteine-aspartic acid specific protease-9 (caspase-9) and Bcl2-associated X (Bax), as well as repressed tumorigenicity in vivo. PMID: 30308516
    9. Plasma NGAL level measured after return of spontaneous circulation can be an early predictor for the development of acute kidney injury after cardiac arrest. PMID: 29131707
    10. LCN2 might play a role in the cross-talk between bone homeostasis and glucose homeostasis. PMID: 29952418
    11. The serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population. PMID: 30035656
    12. Measurement of urinary NGAL levels showed an excellent diagnostic performance for discriminating patients with lupus nephritis from systemic lupus erythematosus without nephritis. PMID: 29533691
    13. In ambulatory healthy women, the relationships among serum LCN2 level, bone density, and osteocalcin were confounded by age and serum creatinine. Although LCN2 was positively related with c-terminal telopeptide of type 1 collagen, the correlation was very weak and may not be physiologically relevant. PMID: 29294226
    14. serum NGAL is an excellent marker for the early diagnosis of febrile UTI, with sensitivity and specificity higher than those of urine NGAL. PMID: 28980274
    15. In this study uNGAL failed to predict contrast induced acute kidney injury (CI-AKI)and was an inadequate triage tool to guide an early intervention strategy to prevent CI-AKI PMID: 28128223
    16. Study results suggest that stratum corneum neutrophil gelatinase-associated lipocalin may be useful as an objective biomarker of changes in acne vulgaris symptoms. PMID: 29473202
    17. Increased serum levels of NGAL were associated with loss of graft function in kidney transplant recipients. PMID: 29528011
    18. In Colombian systemic lupus erythematosus patients, urinary NGAL and MCP-1 in addition to anti-C1q antibodies were useful biomarkers for the identification of renal involvement and discrimination of active lupus nephritis. PMID: 29073812
    19. a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can bypass sites of megalin-dependent recapture, resulting in urinary excretion PMID: 27796299
    20. predictive value of plasma neutrophil gelatinase-associated lipocalin (pNGAL) in patients with severe sepsis PMID: 29572184
    21. Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples. PMID: 30138675
    22. The main finding of the present study was that serum NGAL levels paralleled increasing clinical activity of ulcerative colitis evaluated by Mayo score, and it also discriminated different stages of endoscopic severity of this disease. By contrast, only insignificant association of NGAL with endoscopic activity of Crohn's disease was found with no relationships with clinical activity scores. PMID: 29550798
    23. Upon screening of blood mediators in palmoplantar pustular psoriasis patients, LCN2 emerged as being significantly upregulated compared to healthy participants. PMID: 29395573
    24. Neutrophil gelatinase-associated lipocalin concentrations in the urine and serum on the second day of intensive care unit admission could be used to predict the development of acute kidney injury in the following three to seven days in the intensive care unit; however, the cystatin C concentration did not have predictive value PMID: 28142264
    25. In non-chronic kidney disease group, plasma NGAL was not associated with any baseline variables including iron indices PMID: 28389813
    26. We conclude that the underexpression of CRABP1 and the overexpression of LCN2 may be useful diagnostic biomarkers in thyroid tumours with questionable malignity, and the overexpression of LCN2 and C1QL1 may be useful for prognostic purposes. PMID: 29321030
    27. Blood lipocalin-2 is a biomarker for adipose tissue inflammation in HIV patients treated with antiretroviral therapy. PMID: 29304747
    28. This study illustrates the temporal regulation of NGAL in plasma and CSF, which potentially is a useful reference for studies measuring NGAL as biomarker in older individuals. PMID: 29082525
    29. Higher levels of NGAL in the acute kidney injury patients were associated with high-dose regimen of colistin. PMID: 29190605
    30. bile LCN2 level is a potential diagnostic marker for cholangiocarcinoma. PMID: 27782193
    31. Serum lipocalin-2 concentrations and mortality of severe traumatic brain injury PMID: 28943289
    32. Plasma NGAL is a useful marker of interstitial lesions in patients with chronic kidney disease (CKD) and a predictor of further kidney worsening in the early CKD stage. PMID: 28397074
    33. In STEMI patients, plasma post-percutaneous coronary intervention NGAL levels were decreased compared with pre-pPCI NGAL levels, even with the administration of potentially nephrotoxic contrast medium. Post-NGAL levels seemed to be superior to pre-NGAL levels for the prediction of 30-day mortality outcome. PMID: 28737526
    34. We found that MISP, KLF10, KLF15, PPP1R18, and RXRbeta proteins could strongly respond to TPA stimulation and activate LCN2 transcriptional expression. MEK, ERK, JNK, and P38 kinases were involved in the LCN2 transactivation. Furthermore, the MEK-ERK signal pathway plays a major role in this biological process but does not involve PKCalpha signaling. PMID: 29098164
    35. Nonrenal conditions and systemic severity should be considered for improved AKI prediction by NGAL and L-FABP as biomarkers. PMID: 27605390
    36. NGAL may have some value in non-proteinuric patients and increased values have been observed in persons at risk for Mesoamerican nephropathy--{REVIEW} PMID: 27771693
    37. Studied the role of urinary neutrophil gelatinase-associated lipocalin and albuminuria in the diagnosis of early stage diabetic nephropathy. PMID: 28845433
    38. LCN-2 protein overexpression was positively correlated with MMP-9. PMID: 27339395
    39. The measurement of NGAL appears to predict the occurrence of acute kidney injury after off-pump coronary artery bypass grafting surgery PMID: 28701593
    40. NGAL may have a role in early renal dysfunction even in nonalbuminuric T1D patients PMID: 28620620
    41. Elevated cord blood NGAL concentration seems to be a promising, novel marker, even in subclinical forms of acute kidney injury in asphyxiated neonates. PMID: 27590891
    42. Urinary NGAL levels increase soon after shock wave lithotripsy (SWL). Data suggest that NGAL could be used as an early biomarker of tissue injury after SWL. PMID: 27787615
    43. Results suggest that hippocampal LCN2 upregulation might be a potential pathogenic mechanism leading to further disruption of the hippocampus through neurotoxicity and neuroinflammation in vascular dementia (VaD). Astrocytes seem to be the major source of LCN2 in the hippocampus of rodent models and patients of VaD. Control of hippocampal astrocytic LCN2 expression or activity may be important for neuroprotection in VaD. PMID: 28581123
    44. AUC for day one uNGAL was greater for ICU (AUC=0.85) than in-hospital mortality (AUC=0.74). CONCLUSIONS: Day one uNGAL is a highly accurate predictor of ICU, but less so for in-hospital mortality PMID: 28674715
    45. The urine level of NGAL on the first day of amphotericin B administration was more accurate than serum creatinine in predicting acute kidney injury caused by this agent. PMID: 28575880
    46. Serum neutrophil gelatinase-associated lipocalin level was significantly higher among the total patient cohort and those with sepsis than among the controls, also in patients with systemic inflammatory response syndrome without sepsis and patients without systemic inflammatory response syndrome. Plasma level of neutrophil gelatinase-associated lipocalin was significantly elevated in nonsurvivors compared with survivors. PMID: 28445241
    47. On PICU day 1, interleukin-18 predicted acute kidney injury with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin and liver fatty acid binding protein predicted acute kidney injury with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher. Interleukin-18 and liver fatty acid binding protein on day 1 predicted prolonged acute kidney injury. PMID: 28430754
    48. Resistin and NGAL correlate with expression of endothelial cell adhesion molecules in sepsis. PMID: 28424824
    49. Direct effects of LCN2 on cardiomyocyte size and number and the consistent associations in experimental and human analyses reveal a central role for LCN2 in the ontogeny of cardiac hypertrophy and heart failure PMID: 28615213
    50. Our results suggest that associated serum levels of proMMP-9, NGAL, proMMP-9/NGAL and NE may reflect the state of systemic inflammation in chronic obstructive pulmonary disease related to cigarette smoking. PMID: 28004483

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Cytoplasmic granule lumen. Cytoplasmic vesicle lumen.
  • 蛋白家族:
    Calycin superfamily, Lipocalin family
  • 組織特異性:
    Detected in neutrophils (at protein level). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and
  • 數據庫鏈接:

    HGNC: 6526

    OMIM: 600181

    KEGG: hsa:3934

    STRING: 9606.ENSP00000277480

    UniGene: Hs.204238



主站蜘蛛池模板: 日韩亚洲欧美中文高清在线| 亚洲国产精品综合久久20| 韩国三级无码hd中文字幕| 亚洲欧洲日产国码在线| 久久精品一区二区三区av| 精品国产va久久久久久久冰 | 国产日韩精品中文字无码| 99久久人妻精品免费一区| 亚洲v欧美v日韩v国产v| 日本中文字幕人妻不卡dvd| 装睡被陌生人摸出水好爽| 极品少妇xxxx精品少妇偷拍| 国产麻豆一精品av一免费软件| 欧洲性久久精品| 亚洲精品无码久久久久久| 精品无人国产偷自产在线| 西西人体午夜大胆无码视频| 国产综合有码无码视频在线| 无码任你躁久久久久久老妇 | 999久久欧美人妻一区二区| 国产内射爽爽大片| 国产成人无码a区在线观看视频免费| 国产精品特黄aaaa片在线观看| 成人国产三级在线观看| 亚洲欧美精品伊人久久| 毛片免费全部播放无码| 怡红院一区二区三区在线| 日韩人妻不卡一区二区三区| 粗壮挺进人妻水蜜桃成熟漫画| 高清精品一区二区三区| 日韩毛片在线视频x| 亚洲精品一区三区三区在线观看| 精品国产在天天在线观看| 亚洲国产成人精品无码区宅男| 综合久久国产九一剧情麻豆| 亚洲国产天堂久久综合| 人人妻在人人| 国内最真实的xxxx人伦| 亚洲a∨无码男人的天堂| 欧美情侣性视频| 吃奶呻吟张开双腿做受在线播放|