在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. HSP90AB1 Monoclonal Antibody

HSP90AB1 Monoclonal Antibody

  • 中文名稱：
    HSP90AB1鼠單克隆抗體
  • 貨號：
    CSB-MA000289
  • 規格：
    ￥1090
  • 圖片：
    • Western blot analysis of 1) Hela, 2) Mouse Brain tissue, 3) Rat Brain tissue, diluted at 1:2000.
  • 其他：

產品詳情

  • 產品描述：
    HSP90AB1單克隆抗體（CUSABIO貨號：CSB-MA000289）靶向熱休克蛋白90AB1（HSP90AB1），該蛋白屬于高度保守的分子伴侶家族，在細胞應激響應、蛋白質折疊及信號轉導中發揮關鍵作用，其異常表達與腫瘤發生發展、神經退行性疾病等病理過程密切相關。本產品采用雜交瘤技術制備，經ELISA和Western Blot（WB）嚴格驗證，可特異性識別人、小鼠、大鼠來源的HSP90AB1蛋白，批號穩定且重復性優異，適用于多種科研場景。在基礎研究領域，該抗體可用于探索HSP90AB1在癌癥發生、神經系統疾病中的分子機制，解析其與客戶蛋白的相互作用網絡；在藥物開發中，可作為工具抗體用于靶向HSP90AB1的小分子抑制劑篩選及療效評估實驗。產品經過抗原親和純化處理，在還原與非還原條件下均能保持高效檢測性能，為研究蛋白質穩態調控、細胞應激通路及疾病相關分子標記物提供可靠支持，關鍵詞：HSP90AB1抗體、WB/ELISA驗證、人源/鼠源/大鼠、熱休克蛋白90AB1、分子伴侶研究。
  • Uniprot No.：
  • 基因名：
  • 別名：
    90 kda heat shock protein beta HSP90 beta antibody; D6S182 antibody; FLJ26984 antibody; Heat shock 84 kDa antibody; Heat shock 90kD protein 1; beta antibody; Heat shock 90kDa protein 1 beta antibody; Heat shock protein 90 alpha family class B member 1 antibody; Heat shock protein 90 kDa antibody; Heat shock protein 90kDa alpha (cytosolic) class B member 1 antibody; Heat shock protein 90kDa alpha family class B member 1 antibody; Heat shock protein beta antibody; Heat shock protein HSP 90 beta antibody; Heat shock protein HSP 90-beta antibody; HS90B_HUMAN antibody; HSP 84 antibody; HSP 90 antibody; HSP 90 b antibody; HSP 90b antibody; HSP84 antibody; HSP90 BETA antibody; hsp90ab1 antibody; HSP90B antibody; HSPC2 antibody; HSPCB antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    H, M, R
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 克隆號：
    6F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.
  • 基因功能參考文獻：
    1. The production of IFN-gamma by T cells stimulated with citrullinated HSP90beta demonstrates a bias toward TH1 immune responses that are likely involved in the pathogenesis of rheumatoid arthritis-interstitial lung disease. PMID: 29968330
    2. the expressions of HSP90AB1 can predict prognosis in astrocytic tumors PMID: 27258564
    3. We found that the nutrient value of the culturing medium and the length of induction had significant effect on Hsp90 production in Escherichia coli. Our fast, single-day purification protocol resulted in a stable, well-folded and pure sample that was resistant to degradation in a reproducible manner. PMID: 28651008
    4. Data show that C allele of rs2282151 was associated with increased expression level of heat shock protein 90 alpha family class B member 1 (HSP90AB1). PMID: 27756247
    5. Hsp90beta induced endothelial cell-dependent tumor angiogenesis by activating VEGFRs transcription. PMID: 28359326
    6. The authors find that the interaction between sB-Raf and the Hsp90 chaperone system is based on contacts with the M domain of Hsp90, which contributes in forming the ternary complex with Cdc37 as long as the kinase is not stabilized by nucleotide. PMID: 27620500
    7. High HSP90B expression is associated with laryngeal carcinoma. PMID: 27959448
    8. The expression level of Hsp90AB1 in lung cancer tissues was significantly higher than that in normal lung tissue and was associated with lung cancer pathological type and overall survival in lung adenocarcinoma patients. PMID: 26903158
    9. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes. PMID: 26511315
    10. HSP90AB1: Helping the good and the bad PMID: 26358502
    11. These results suggest a means by which the hsp90beta interaction could prevent apo-sGCbeta1 from associating with its partner sGCalpha1 subunit while enabling structural changes to assist heme insertion into the H-NOX domain. PMID: 26134567
    12. Casein kinase 2-mediated phosphorylation of Hsp90beta and stabilization of PXR is a key mechanism in the regulation of MDR1 expression. PMID: 25995454
    13. This study identifies overexpression of HSP90 (especially isoform HSP90AB1) and its clients ATR, ATM, and NBS1 as promising markers for radioresistant, aggressive soft tissue sarcomas with particularly poor prognosis. PMID: 26044951
    14. The proteins (HSP90b, TMS1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases. PMID: 25191796
    15. The expression levels of Hsp90-beta and annexin A1 positively correlated and such co-overexpression of Hsp90-beta and annexin A1 contributed to lung cancer diagnosis. PMID: 25300907
    16. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells. PMID: 24466266
    17. A novel mechanism for human carcinogenesis via methylation of HSP90AB1 by SMYD2. PMID: 24880080
    18. Hsp90 is upregulated in systemic sclerosis (SSc) and is critical for TGF-beta signalling. PMID: 23661493
    19. HSP70 was massively up-regulated in all mast cells three months after irradiation whereas HSP90AB1 was up-regulated only in a portion of mast cells PMID: 24670792
    20. Study obtained a structural model of Hsp90 in complex with its natural disease-associated substrate, the intrinsically disordered Tau protein. Hsp90 binds to a broad region in Tau that includes the aggregation-prone repeats. PMID: 24581495
    21. HSP90beta may positively regulate angiogenesis, not only as a protein chaperone, but also as an mRNA stabilizer for pro-angiogenic genes, such as BAZF, in a PRKD2 activity-dependent manner. PMID: 23515950
    22. Here we describe the specific association of heat shock protein-90-beta (Hsp90beta) with EV71 viral particles by the co-purification with virions using sucrose density gradient ultracentrifugation and colocalization as shown by immunogold EM. PMID: 23711381
    23. differences in expression caused by the -144 polymorphism in the HSP90beta promoter are associated with cellular inflammatory responses and the severity of organ injury PMID: 23516526
    24. the transdominant effect of HSP90AB1 on capsid-spacer protein 1-mutant HIV infectivity suggests a potential role for this class of cellular chaperones in HIV core stability and uncoating. PMID: 23200770
    25. The upregulation of Hsp90-beta was associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients PMID: 22929401
    26. DNA sequencing of 101 human samples detects eight and seven unique single nucleotide polymorphisms (SNPs) at the HSP90AA1 and HSP90AB1 loci, respectively. PMID: 22185817
    27. a possible role for HSP90AB1 in postentry HIV replication and may provide an attractive target for therapeutic intervention. PMID: 21602280
    28. TRIM8 modulates translocation of phosphorylated STAT3 into the nucleus through interaction with Hsp90beta and consequently regulates transcription of Nanog in embryonic stem cells. PMID: 21689689
    29. cyclophilin A and Hsp90 facilitate translocation of lethal factor(N) diphtheria toxin, but not of lethal factor, across endosomal membranes, and thus they function selectively in promoting translocation of certain proteins, but not of others PMID: 20946244
    30. Results show that RPL4, RPLP0, and HSPCB were the most stable reference genes in ovarian tissues. PMID: 20705598
    31. H. pylori induces the translocation of HSP90beta from the cytosol to the membrane and interaction of HSP90beta and Rac1, which leads to the activation of NADPH oxidase and production of ROS in gastric epithelial cells. PMID: 20451655
    32. findings present novel Hsp90 mutants that render cells resistant to Hsp90 inhibitors; show that the resistance depends on the increased ATPase turnover due to enhanced interaction with Aha1 PMID: 20226818
    33. Data show that the small molecule celastrol inhibits the Hsp90 chaperoning machinery by inactivating the co-chaperone p23, resulting in a more selective destabilization of steroid receptors. PMID: 19996313
    34. Study points to a potential role for Hsp90beta in MSC biology. PMID: 19327008
    35. PKC-epsilon is specifically required in the signaling pathway leading to the induction of hsp90 beta gene in response to heat shock. PMID: 14532285
    36. hsp90beta is repressed by p53 in UV irradiation-induced apoptosis PMID: 15284248
    37. Mutations at the phosphorylation sites of HSP90-beta modulate the interaction with arylhydrocarbon receptor (AhR) and may negatively regulate formation of the functional AhR complex in the steady-state cytosol. PMID: 15581363
    38. Hydrogen-exchange mass spectrometry was used to study structural & conformational changes undergone by full-length Hsp90beta in solution upon binding of the co-chaperone Cdc37 & 2 Hsp90 ATPase inhibitors: Radicicol & the anticancer drug DMAG PMID: 17764690
    39. Results suggest that HSP90 beta prevents auto-ubiquitination and degradation of its client protein c-IAP1, whose depletion would be sufficient to inhibit cell differentiation. PMID: 18239673
    40. These data provide an explanation for apoptosome inhibition by activated leukemogenic tyrosine kinases and suggest that alterations in Hsp90beta-apoptosome interactions may contribute to chemoresistance in leukemias. PMID: 18591256
    41. Presence of ovarian autoantibodies to human HSP90 in sera of women with infertility could be involved in human ovarian autoimmunity and thereby be a causative factor in early ovarian failure. PMID: 19022436
    42. Results show that heat shock protein 90 beta is cleaved by activated caspase-10 under UVB irradiation. PMID: 19380486
    43. celastrol may represent a new class of Hsp90 inhibitor by modifying Hsp90 C terminus to allosterically regulate its chaperone activity and disrupt Hsp90-Cdc37 complex. PMID: 19858214

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Melanosome. Nucleus. Secreted. Cell membrane. Dynein axonemal particle.
  • 蛋白家族：
    Heat shock protein 90 family
  • 數據庫鏈接：

    HGNC: 5258

    OMIM: 140572

    KEGG: hsa:3326

    STRING: 9606.ENSP00000325875

    UniGene: Hs.509736



主站蜘蛛池模板： 丝袜高潮流白浆潮喷在线播放| 久久人人爽人人爽人人片av麻烦| 国产另类ts人妖一区二区| 加勒比无码人妻东京热| 国产成人av一区二区三区无码| 久久综合亚洲欧美成人| 日韩av片无码一区二区不卡电影| 熟女人妻aⅴ一区二区三区60路| 色老久久精品偷偷鲁| 特黄做受又大又粗又长大片| 亚洲精品国男人在线视频| 巨胸爆乳美女露双奶头挤奶| 日韩国产丝袜人妻一二区| 国产精品无码一区二区在线a片| 亚洲色无码专区在线观看| 沈阳45老熟女高潮喷水亮点| 亚洲一区二区三区av无码| 尤物国精品午夜福利视频| 欧美精品videosbestsex日本| 精品人妻av区乱码| 亚洲中文字幕久在线| 成人免费视频在线观看地区免下载 | 国产成人8x人在线视频软件| 成人免费精品网站在线观看影片| 40岁成熟女人牲交片20分钟| 人妻丰满熟妇无码区免费| 2019久久视频这里有精品15| 欧美又黄又大又爽a片三年片| 中文字幕精品亚洲无线码二区| 少妇内射兰兰久久| 欧美成人精品三级网站视频| 人人添人人澡人人澡人人人人| 97se亚洲精品一区| 国产成人欧美亚洲日韩电影| 国产下药迷倒白嫩美女网站| 国产成人无码一区二区在线观看| 忘忧草www中文在线资源| 美女扒开腿让男人桶爽揉| 精品人妻少妇一区二区三区| 久久综合色鬼综合色| 色舞月亚洲综合一区二区|