在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 單克隆抗體
  4. GSTM3 Monoclonal Antibody

GSTM3 Monoclonal Antibody

  • 中文名稱：
    GSTM3鼠單克隆抗體
  • 貨號：
    CSB-MA009982A1m
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, A549 whole cell lysate, Rat brain tissue
      All lanes: GSTM3 antibody at 1:1000
      Secondary
      Goat polyclonal to mouse IgG at 1/50000 dilution
      Predicted band size: 27 KDa
      Observed band size: 27 KDa
      Exposure time：10min
    • IHC image of CSB-MA009982A1m diluted at 1:100 and staining in paraffin-embedded human testes tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Overlay Peak curve showing Hela cells stained with CSB-MA009982A1m (red line) at 1:100. The cells were incubated in 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 1h at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/100 dilution for 30min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • 產品描述：
    CUSABIO貨號：CSB-MA009982A1m GSTM3單克隆抗體是針對谷胱甘肽S-轉移酶Mu3（GSTM3）研發的高特異性科研試劑，該靶標蛋白屬于Ⅱ期代謝酶家族成員，在細胞解毒代謝和氧化應激調控中發揮重要作用，其表達異常與多種腫瘤發生發展密切相關。本產品采用雜交瘤技術制備，經ELISA、蛋白質印跡（WB）、免疫組織化學（IHC）及流式細胞術（FC）多平臺驗證，可特異性識別人源GSTM3蛋白，具有批次穩定性高、交叉反應性低的特點。在1:1000稀釋比下WB實驗顯示清晰條帶，IHC染色能準確呈現組織樣本中GSTM3的亞細胞定位。適用于腫瘤發生機制研究、藥物代謝通路分析、氧化應激相關信號轉導實驗等前沿領域，為探索GSTM3在癌癥生物標志物篩選、化療耐藥性研究及抗氧化治療開發提供可靠工具。該GSTM3抗體具有多平臺兼容性，可滿足蛋白質表達譜分析、病理切片檢測和細胞表面標記物研究等多元化實驗需求，是開展分子毒理學和腫瘤微環境研究的優選試劑。
  • 產品名稱：
    Mouse anti-Homo sapiens (Human) GSTM3 Monoclonal Antibody antibody
  • Uniprot No.：
  • 基因名：
    GSTM3
  • 別名：
    brain GST antibody; brain type mu glutathione S transferase antibody; glutathione S alkyltransferase M3 antibody; glutathione S aryltransferase M3 antibody; glutathione S transferase M3 (brain) antibody; glutathione S transferase M3 antibody; Glutathione S transferase Mu 3 antibody; glutathione S transferase, Mu 3 antibody; Glutathione S-transferase Mu 3 antibody; GST class mu 3 antibody; GST class-mu 3 antibody; GST5 antibody; GSTB antibody; Gstm3 antibody; GSTM3-3 antibody; GSTM3_HUMAN antibody; GTM3 antibody; hGSTM3-3 antibody; MGC3310 antibody; MGC3704 antibody; S (hydroxyalkyl)glutathione lyase M3 antibody
  • 宿主：
    Mouse
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Glutathione S-transferase Mu 3 protein (1-225AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal Antibody
  • 抗體亞型：
    IgG1
  • 純化方式：
    >95%, Protein G purified
  • 克隆號：
    2H9D7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.
  • 基因功能參考文獻：
    1. Differential activity of antioxidant enzymes caused by the polymorphism in GSTM3 may contribute to resistance to hormonal therapy through oxidative stress. The GSTM3 rs7483 polymorphism may be a promising biomarker for prostate cancer patients treated with androgen-deprivation therapy (ADT) PMID: 27993795
    2. Expression of GSTM3 might be regulated by epigenetic changes in lens tissue. Hypermethylation in GSTM3 promoter and altered histone modification might have a role in the ARC formation. PMID: 27607418
    3. No associations between the GSTT1, GSTP1, and GSTM3 genotypes and neoplasia risk were observed. In conclusion, we determined the genotype distribution of GST polymorphisms in control subjects and breast cancer patients from northeastern Mexico. PMID: 26125851
    4. NSD1 interacted with RNAPII and bound to GSTM3 -63A/C TATA box. PMID: 25193115
    5. All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis. PMID: 22430872
    6. This meta-analysis suggests that the GSTM3 A/B polymorphism may be an important protective factor for head and neck cancer, especially of laryngeal cancer and Caucasian populations. PMID: 24416175
    7. rs1332018 genetic variants in the GSTM3 promoter predispose the host to downregulating GSTM3 expression in kidney, facilitate carcinogenesis, and predict an unfavourable postoperative prognosis of renal cell carcinoma. PMID: 24157827
    8. In conclusion, this epistatic interaction showed a high degree of consistency when stratifying by sex, the epsilon4 allele of apolipoprotein E genotype, and geographic region. PMID: 23036584
    9. The GSTM3 A/B gene polymorphism is not associated with lung cancer susceptibility. PMID: 23167362
    10. Methylation of GSTM3 promoter may contribute to oxidative stress-associated liver damage and correlate with the disease severity in Acute-on-chronic hepatitis B liver failure. PMID: 22976281
    11. There were no significant differences in distribution of 3-bp deletion polymorphism in intron 6 variant allele in Glutathione-S-transferase M3 between chronic obstructive pulmonary disease patients and controls in a north Indian population. PMID: 21513434
    12. In individuals from Angola, Mozambique and the Sao Tome e Principe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. PMID: 20549140
    13. Diminished GSTM3 mRNA levels correlated with decreased minichromosome maintenance deficient 3 (MCM3) mRNA levels in a diagnostic and SNP-dependent fashion in Alzheimer disease. PMID: 18423940
    14. The presence of the GSTM3*B allele appears to associated with a reduced risk of laryngeal squamous cell carcinoma. PMID: 19922706
    15. No increased prostate scancer risk for men carrying any of the GSTM1 or GSTT1 genotypes. PMID: 14968442
    16. Glutathione S-transferase hGSTM3 has a role in ageing-associated neurodegeneration PMID: 15621212
    17. GSTM3 -63C allele strongly affects gene expression and suggests that individuals who carry the low expression allele may be deficient in glutathione transferase catalyzed biological functions. PMID: 15665284
    18. Single marker association analyses revealed that the AGG/AGG genotype of the GSTM3 rs1799735 (del/AGG) polymorphism was associated with an increased risk of AD (p=0.05), especially in the group of APOE4-allele non-carriers (p=0.004; OR=2.07). PMID: 17904251
    19. distribution of -63A/C polymorphism of human glutathione S-transferase M3(GSTM3) gene in Chinese Han population and the association of -63A/C polymorphism with essential hypertension PMID: 17922434
    20. The GSTM3*A/*A genotype was 76% in cancer cases versus 74% in controls; a significant association between smoking status and GSTM3 genotype was not detected. PMID: 18569590
    21. Our results suggested GSTM3 (AB + BB) genotype to be significantly associated with prostate cancer risk. PMID: 18668224
    22. GST-M3 activity is possibly involved in protection against mucosal atrophy caused by H. pylori as the levels of IgG titer and pepsinogen I are linked to mucosal status. PMID: 19696791
    23. The researchers found evidence of an increased risk for non-Hodgkin's lymphoma in women who used hair dye before 1980 and who were carriers of the GSTM3 intron 6 deletion. PMID: 19822571

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Mu family
  • 組織特異性：
    Testis and brain.
  • 數據庫鏈接：

    HGNC: 4635

    OMIM: 138390

    KEGG: hsa:2947

    STRING: 9606.ENSP00000256594

    UniGene: Hs.2006



主站蜘蛛池模板： 四虎国产精品永久地址入口| 五十路熟妇亲子交尾| 婷婷丁香五月六月综合激情啪| 开心色怡人综合网站| 成人毛片18女人毛片免费| 97人妻人人揉人人躁人人| 亚洲中文字幕日产无码成人片| 国产免费爽爽视频| 久久久精品人妻一区二区三区gv| 色 综合 欧美 亚洲 国产| 久久午夜福利无码1000合集| 日本边添边摸边做边爱喷水| 免费无遮挡很爽很污很黄的网站| 国产又粗又硬又大爽黄老大爷 | 最大胆裸体人体牲交免费| 草草地址线路①屁屁影院成人| 欧美乱妇狂野欧美在线视频| 婷婷色香合缴缴情av第三区| 国产成人av一区二区三区无码| 国产微拍精品一区二区| 人人妻人人澡人人爽欧美二区| 国产又色又爽无遮挡免费 | 亚洲国产精品无码专区影院| 美女大量吞精在线观看456| 精品久久久久久综合日本| 中国内射xxxx6981少妇| 欧美综合在线激情专区| 精品无码一区二区三区在线| 亚洲熟妇无码av另类vr影视| h人成在线看免费视频| 毛片免费全部播放无码| 国产精品亚洲专区无码牛牛| 无码高潮又爽又黄a片日本动漫| 国产牛仔裤网站精品| 中文字幕精品久久久久人妻红杏1 久久久精品日本一区二区三区 | 67194成是人免费无码| 国产成人无码a区视频| 国产人在线成免费视频| 免费做a爰片久久毛片a片| 亚洲天堂2017无码中文| 欧美性猛交xxxxx按摩欧美|