在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CEP55 Monoclonal Antibody

  • 中文名稱:
    CEP55 Monoclonal Antibody
  • 貨號:
    CSB-MA977360
  • 規格:
    ¥1320
  • 圖片:
    • Flow cytometric analysis of Centrosomal protein 55 expression in HeLa cells using Centrosomal protein 55 antibody. Green, isotype control; red, Centrosomal protein 55.
    • Western blotting analysis using centrosomal protein 55 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with centrosomal protein 55 antibody and HRP-conjugated goat anti-mouse secondary antibody respectively.
  • 其他:

產品詳情

  • 產品名稱:
    Mouse anti-Homo sapiens (Human) CEP55 Monoclonal antibody
  • Uniprot No.:
  • 基因名:
    CEP55
  • 別名:
    CEP55; Centrosomal Protein 55; C10orf3; CT111; Up-Regulated In Colon Cancer 6; Centrosomal Protein Of 55 KDa; Cancer/Testis Antigen 111; Centrosomal Protein 55kDa; FLJ10540; URCC6; Chromosome 10 Open Reading Frame 3; MARCH; Cep55
  • 宿主:
    Mouse
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CEP55 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    Mouse IgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    9H5
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2500
    FC 1:200-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney.
  • 基因功能參考文獻:
    1. A significant over expression of forkhead box protein M1 (FOXM1), polo-like kinase 1 (PLK1) and centrosomal protein 55 (CEP55) was observed in tumor samples compared to adjacent and normal bladder tissues, suggesting they may be potential candidate's biomarkers for early diagnosis and targets for cancer therapy. PMID: 30277841
    2. our data suggest that CEP55 can be used as a prognostic marker for osteosarcoma PMID: 29579156
    3. CEP55 was increased in lung cancer cells. PMID: 29750778
    4. whole-exome sequencing lead to identification of a homozygous nonsense mutation c.256C>T (p.Arg86*) in CEP55 (centrosomal protein of 55 kDa) in autosomal recessive Meckel syndrome fetus. PMID: 28295209
    5. CEP55 loss of function mutations likely underlie MARCH, a novel multiple congenital anomaly syndrome. PMID: 28264986
    6. A FAK-Src signaling pathway downstream of integrin-mediated cell adhesion was found to decelerate both PLK1 degradation and CEP55 accumulation at the midbody. These data identify the regulation of PLK1 and CEP55 as steps where integrins exert control over the cytokinetic abscission. PMID: 27127172
    7. Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein) PMID: 28620049
    8. Aberrant CEP55 expression may predict unfavorable clinical outcomes in epithelial ovarian carcinoma (EOC) patients and play an important role in regulating invasion in ovarian cancer cells. Thus, CEP55 may serve as a prognostic marker and therapeutic target for EOC PMID: 26615423
    9. CEP55 plays a crucial role in promoting breast cancer cell proliferation and it might be a potential therapeutic target in breast cancer. PMID: 26902787
    10. In depth discussion of the functions of CEP55 across different effector pathways, and also its roles as a biomarker and driver of tumorigenesis, commemorating a decade of research on CEP55. [review] PMID: 25915844
    11. Which was required for FLJ10540/MMP-7 or FLJ10540/MMP-10 expressions. PMID: 25889801
    12. myotubularin-related protein 3 and myotubularin-related protein 4 may act as a bridge between CEP55 and polo-like kinase 1, ensuring proper CEP55 phosphorylation and regulating CEP55 recruitment to the midbody. PMID: 25659891
    13. CEP55 mRNA/protein expression was observed is specific to TCC of human urinary bladder and might be used as a diagnostic biomarker and vaccine target in development of BC specific immunotherapy. PMID: 25178936
    14. cellular proliferation was suppressed as a result of cell cycle arrest at the G2/M phase in CEP55-knockdown cells PMID: 24390615
    15. FLJ10540 may be critical regulator of disease progression in nasopharygeal carcinoma, and the underlying mechanism may involve in the osteopontin/CD44 pathway. PMID: 22591637
    16. At the midbody, BRCA2 influences the recruitment of endosomal sorting complex required for transport (ESCRT)-associated proteins, Alix and Tsg101, and formation of CEP55-Alix and CEP55-Tsg101 complexes during abscission. PMID: 22771033
    17. the existence of a p53-Plk1-Cep55 axis in which p53 negatively regulates expression of Cep55, through Plk1 which, in turn, is a positive regulator of Cep55 protein stability. PMID: 22184120
    18. Data provide strong evidence that CEP55 and HELLS may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression. PMID: 20400365
    19. Data show that Plk1 activity negatively regulates Cep55 to ensure orderly abscission factor recruitment and ensures that this occurs only once cell contraction has completed. PMID: 21079244
    20. Cep55 is stabilized in a phosphorylation- and Pin1-dependent manner. PMID: 19855176
    21. data suggest a possible involvement of CEP55 in centrosome-dependent cellular functions, such as centrosome duplication and/or cell cycle progression, or in the regulation of cytokinesis PMID: 16406728
    22. This study defines a cellular mechanism that links centralspindlin to Cep55, which, in turn, controls the midbody structure and membrane fusion at the terminal stage of cytokinesis. PMID: 16790497
    23. By forming a complex with phosphatidylinositol 3'-kinase, FLJ10540 activates the PI3-kinase/AKT proto-oncogene protein pathways, providing a mechanistic basis for FLJ10540-mediated oncogenesis. PMID: 17237822
    24. study shows that two proteins involved in HIV-1 budding-Tsg101, a subunit of the endosomal sorting complex required for transport I (ESCRT-I), & Alix, an ESCRT-associated protein-were recruited to the midbody during cytokinesis by interaction with Cep55 PMID: 17556548
    25. that ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1. PMID: 17853893
    26. the Cep55/Alix/ESCRT-III pathway has a role in cytokinesis and HIV-1 release PMID: 18641129
    27. crystal structure of the ESCRT and ALIX-binding region (EABR) of CEP55 bound to an ALIX peptide at a resolution of 2.0 angstroms; structure shows that EABR forms an aberrant dimeric parallel coiled coil PMID: 18948538
    28. FLJ10540 is not only an important prognostic factor but also a new therapeutic target in the FLJ10540/FOXM1/MMP-2 pathway for oral cavity squamous cell carcinoma treatment. PMID: 19525975
    29. protein could be detected in breast- and lung carcinoma 9but not normal) tissues PMID: 19609239

    顯示更多

    收起更多

  • 相關疾病:
    Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly (MARCH)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody, Midbody ring.
  • 組織特異性:
    Expressed in embryonic brain. Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex. Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level). Widely expressed,
  • 數據庫鏈接:

    HGNC: 1161

    OMIM: 236500

    KEGG: hsa:55165

    STRING: 9606.ENSP00000360540

    UniGene: Hs.14559



主站蜘蛛池模板: 国产精品人成视频免费999| 国产老熟女狂叫对白| 国产久久精品| 免费体验区试看120秒| 无码精品a∨在线观看无广告| 久久久久 亚洲 无码 av 专区 | 天天澡天天揉揉av无码| 人妻系列无码专区免费视频| 日本护士毛茸茸| 久久九九av免费精品| 欧美亚洲人成网站在线观看| 午夜伦费影视在线观看| 欧美三根一起进三p| 欧美一区二区三区视频在线观看 | 欧美视频专区一二在线观看| 肥老熟妇伦子伦456视频| 成年男人裸j照无遮挡无码| 国产免费爽爽视频在线观看| 久久av高潮av无码av喷吹| 久激情内射婷内射蜜桃| 在线播放真实国产乱子伦| 欧美成人形色生活片| 欧美又粗又大xxxxbbbb疯狂| 国产精品爽黄69天堂a| 少妇spa推油被扣高潮| 亚洲人成人无码www影院| 亚洲成av人片久久| 亚洲综合另类小说色区| 国产一区二区三区不卡在线看| 欧美大胆少妇bbw| 欧美变态暴力牲交videos| 亚洲欧美偷拍另类a∨| 伊人久久综合色| 米奇影视第四色| 国产成人亚洲综合网站小说 | 51久久国产露脸精品国产| 人妻无码一区二区三区av| 久久久99无码一区| 久久精品青草社区| 无码人妻aⅴ一区二区三区有奶水| 中文字幕乱码一区二区免费|