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  4. CD79A Monoclonal Antibody

CD79A Monoclonal Antibody

  • 中文名稱：
    CD79A鼠單克隆抗體
  • 貨號(hào)：
    CSB-MA961575
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-MA961575 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD79a單克隆抗體（CUSABIO貨號(hào)：CSB-MA961575）是針對(duì)B細(xì)胞特異性表面標(biāo)志物CD79a靶點(diǎn)研發(fā)的高特異性科研試劑，該靶點(diǎn)作為B細(xì)胞受體（BCR）復(fù)合物的關(guān)鍵信號(hào)轉(zhuǎn)導(dǎo)亞基，在B細(xì)胞發(fā)育、分化及免疫應(yīng)答調(diào)控中發(fā)揮核心作用。本產(chǎn)品經(jīng)ELISA和免疫組化（IHC）雙重平臺(tái)驗(yàn)證，可精準(zhǔn)識(shí)別人源CD79a抗原，其穩(wěn)定的抗原結(jié)合特性使其成為研究B細(xì)胞相關(guān)免疫機(jī)制的重要工具。在免疫學(xué)研究領(lǐng)域，該抗體適用于B細(xì)胞淋巴瘤的分子標(biāo)記分析、自身免疫性疾病（如系統(tǒng)性紅斑狼瘡）的病理機(jī)制探索以及免疫微環(huán)境中B細(xì)胞亞群的功能鑒定等科研場(chǎng)景。通過(guò)特異性識(shí)別跨膜結(jié)構(gòu)域表位，該單克隆抗體可清晰定位B細(xì)胞在組織切片中的分布狀態(tài)，同時(shí)滿足體外蛋白互作研究的定量檢測(cè)需求。作為經(jīng)過(guò)嚴(yán)格質(zhì)控的科研級(jí)抗體，其高批次穩(wěn)定性可為流式細(xì)胞術(shù)預(yù)實(shí)驗(yàn)、免疫印跡交叉驗(yàn)證等多元化研究提供可靠支持，助力研究人員深入解析B細(xì)胞介導(dǎo)的免疫調(diào)控網(wǎng)絡(luò)及疾病發(fā)生發(fā)展機(jī)制。
  • 產(chǎn)品名稱：
    Mouse anti-Homo sapiens (Human) CD79A Monoclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD79A; IGA; MB1; B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein; CD antigen CD79a
  • 宿主：
    Mouse
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from human CD79a
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    IgG2a, Kappa
  • 純化方式：
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • 克隆號(hào)：
    20B11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
  • 基因功能參考文獻(xiàn)：
    1. The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status. PMID: 27915469
    2. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part. PMID: 24769851
    3. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
    4. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. PMID: 24146823
    5. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. PMID: 21324920
    6. CD79a may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
    7. Unlike the B29 octamer motif, the mb-1 octamer motif does not have the essential sequence required for OBF-1/Bob1 interaction, therefore its promoter is not transactivated by OBF-1/Bob1. PMID: 11907094
    8. B cell-restricted mb-1 gene: expression, function, and lineage infidelity. Review. PMID: 12403343
    9. There is a somatic hypermutation of this gene in B-cell lymphoma and multiple myeloma. PMID: 12651942
    10. Results indicate that PAX5 is a more specific marker than CD79a for B-cell ALL diagnosis. PMID: 15492262
    11. lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains. PMID: 15591116
    12. FISH findings indicate that CD79a, despite its specificity for B-cell differentiation, represented the aberrant presence of a B-cell antigen in leukemias of distinct myeloid linage. PMID: 16271957
    13. Acute leukemia with t(8;21) coexpresses CytCD79a represent biphenotypic acute leukemia. PMID: 17350472
    14. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma. PMID: 17374736
    15. Ig-alpha was phosphorylated in all myeloma IgG BCR isolates, the 31-kD variant being phosphorylated most frequently. It was not phosphorylated in normal control B cells. PMID: 17701175
    16. Median survival time of cytoplasmic CD79 alpha positive group was shorter than that of cytCD79a negative group in acute myeloid leukemia. PMID: 18160827

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  • 相關(guān)疾病：
    Agammaglobulinemia 3, autosomal recessive (AGM3)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    B-cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1698

    OMIM: 112205

    KEGG: hsa:973

    STRING: 9606.ENSP00000221972

    UniGene: Hs.631567



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