ABCB5 Monoclonal Antibody
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中文名稱:ABCB5鼠單克隆抗體
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貨號:CSB-MA000232
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規格:¥1090
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圖片:
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其他:
產品詳情
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產品描述:ABCB5單克隆抗體(CUSABIO貨號:CSB-MA000232)是針對人源ABCB5靶點開發的高特異性科研試劑,該靶點作為ATP結合盒轉運蛋白家族成員,在腫瘤干細胞表型維持、藥物外排及組織再生等生物學過程中發揮關鍵調控作用。本產品采用雜交瘤技術制備,經嚴格的ELISA和Western Blot(WB)平臺驗證,可特異性識別天然構象的ABCB5蛋白,適用于腫瘤耐藥機制研究、干細胞特性分析及組織特異性表達檢測等基礎科研領域。該抗體具有高批次穩定性,推薦用于石蠟切片/冰凍切片的免疫組化實驗以及細胞裂解液的蛋白互作研究,為探索ABCB5在黑色素瘤、結直腸癌等惡性腫瘤中的功能提供可靠工具。在實驗方案設計中,建議結合靶蛋白分子量特征(約130kDa)進行WB結果判讀,同時可通過多模型交叉驗證提升實驗數據的可靠性。本產品專注于腫瘤生物學、分子病理學等前沿領域研究,為揭示ABCB5介導的多藥耐藥機制及開發新型抗癌策略提供優質抗體支持。
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Uniprot No.:
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基因名:ABCB5
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別名:ABCB 5 antibody; ABCB5 antibody; ABCB5 P-gp antibody; ABCB5_HUMAN antibody; ABCB5alpha antibody; ABCB5beta antibody; ATP binding cassette protein antibody; ATP binding cassette sub family B (MDR/TAP) member 5 antibody; ATP binding cassette sub family B member 5 antibody; ATP-binding cassette sub-family B member 5 antibody; EST422562 antibody; P glycoprotein ABCB5 antibody; P-glycoprotein ABCB5 antibody
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宿主:Mouse
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反應種屬:Human
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免疫原:Synthetic Peptide
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免疫原種屬:H
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標記方式:Non-conjugated
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抗體亞型:IgG
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克隆號:12F4
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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產品提供形式:Liquid
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應用范圍:ELISA,WB
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推薦稀釋比:
Application Recommended Dilution WB 1:500-1:5000 -
Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關產品
靶點詳情
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功能:Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
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基因功能參考文獻:
- Interaction analysis demonstrated that the following genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were associated with a prothrombin time >/=12 sec and with Recurrent pregnancy loss (RPL) risk PMID: 29956771
- No significant influence of the three newly identified ABCB5 polymorphisms. PMID: 26975227
- The ABCB5 activates the NF-kappaB pathway by inhibiting p65 ubiquitination to enhance p65 protein stability. PMID: 28821433
- Data indicate that the energy metabolism was virtually unaffected by ATP-binding cassette member B5 (ABCB5) expression. PMID: 27560924
- The expression of ZEB1 in tissues is positively relevant to ABCB5 in breast cancer. PMID: 28281973
- Findings demonstrated that the expression of ABCB5 was upregulated in ocular surface squamous neoplasia (OSSN) and that elevated expression of ABCB5 may be involved in the pathogenesis of OSSN. PMID: 26843453
- Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane. PMID: 26965478
- ABCB5 has a role in chemoresistance in Merkel Cell Carcinoma PMID: 26827764
- Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons. PMID: 26666373
- ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1. PMID: 26321644
- This is the first study showing the relationship between miR-340-5p and expression of ABCB5 in melanoma cells PMID: 26554847
- c-MYC confers resistance to 5-fluorouracil through regulating ABCB5 expression in human colon cancer cells. PMID: 25689483
- ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans. PMID: 25647612
- The resistance of CD133(+) melanoma subpopulation is attributed to the enhanced drug efflux mediated by ATP-binding cassette sub-family B member 5 (ABCB5), since the knockdown of ABCB5 was found to sensitize CD133(+) cells to CAPE. PMID: 25449786
- In melanoma-initiating cells, ABCB5 controls IL1beta secretion, which serves to maintain slow cycling, chemoresistant cells through an IL1beta/IL8/CXCR1 cytokine signaling circuit. PMID: 24934811
- Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression. PMID: 24525737
- ABCB5 and MDR1 gene expression correlate with drug resistance in acute leukemia patients. PMID: 24804815
- ATP-binding cassette, sub-family B, member 5 (ABCB5) marks limbal stem cells (LSCs) and is required for LSC maintenance, corneal development and repair PMID: 25030174
- Our results show that ABCB5 is preferentially expressed in the cytotrophoblast layer of placental villi. PMID: 24300535
- Novel associations of the ABCB5 K115E polymorphism with human pigmentation phenotype and melanoma risk are observed. PMID: 23770371
- Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Three ABCB5 SNPs, i.e. rs10231520, rs17817117 and rs2301641 (encoding the non-synonymous amino acid change K115E), were associated with decreased clinical melanoma risk. Additionally, the rs2301641 SNP was associated with non-red compared to red human hair color. PMID: 23770371
- High ABCB5 expression was significantly associated with tumour progression and recurrence of the tumour. PMID: 22784549
- Data show that CD133(+) and ABCB5(+) subpopulations are colocalized in melanomas in perivascular niches that contain CD144 (VE-cadherin)(+) melanoma cells forming vessel-like channels, a phenomenon termed vasculogenic mimicry (VM). PMID: 22865455
- The gradual increase in the expression of ABCB5 from benign nevus to in situ to invasive melanoma suggests that it plays a role in melanomagenesis. PMID: 22555176
- ABCB5 may be responsible for both the progression and chemotherapeutic refractoriness of advanced acute leukemia. PMID: 22044138
- the helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression PMID: 22393060
- ABCB5 mediates 5-FU resistance in cultured human colorectal cancer cells and affected tumor growth in xenografts. PMID: 21652540
- ABCB5 beta may have evolved to play a specific role in human pigment cells and/or melanoma cells where it is predominantly expressed. PMID: 21298007
- Results demonstrate that VEGFR-1 expressed by ABCB5+ malignant melanoma initiating cells functions to induce tumor vasculogenic mimicry and associated production of the pro-proliferative melanoma mitogen laminin, thereby promoting tumor growth. PMID: 21212411
- Results identify novel T-cell modulatory functions of ABCB5(+) melanoma subpopulations and suggest specific roles for these malignant melanoma initiating cells in the evasion of antitumor immunity and in cancer immunotherapeutic resistance. PMID: 20068175
- Expression of GEP and ABCB5 in liver cancer stem cells is associated with chemoresistance and reduced survival times of patients with hepatocellular carcinoma. PMID: 20682318
- Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. PMID: 20729912
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
- expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas PMID: 15760339
- 6-mercaptopurine decreased iNOS expression and increased MRP5 mRNA levels. PMID: 17661346
- ABCB5 expression identifies melanoma stem cells and correlates with clinical disease progression in melanoma patients. In vivo targeting of ABCB5+ melanoma stem cells inhibits tumor growth in human to mouse melanoma xenotransplantation models. PMID: 18202660
- ABCB5 mediates chemoresistance in stem cell phenotype-expressing human malignant melanoma cells. PMID: 15899824
- ABCB5 P-glycoprotein functions include: Regulation of progenitor cell fusion; Regulation of cell membrane potential; Rhodamine-123 transport. PMID: 12960149
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亞細胞定位:Cell membrane; Multi-pass membrane protein.
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蛋白家族:ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
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組織特異性:Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expr
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