在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca mulatta Interleukin-6 protein (IL6)

In Stock
  • 中文名稱:
    獼猴IL6重組蛋白
  • 貨號:
    CSB-AP003101MOW
  • 規格:
    ¥2124
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >97% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg.
  • 基因名:
  • Uniprot No.:
  • 別名:
    IL6Interleukin-6; IL-6
  • 種屬:
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.Coli
  • 分子量:
    21.1 kDa
  • 表達區域:
    28-212aa
  • 氨基酸序列
    M+APVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered concentrated solution in 50 mM Tris-HCl, pH9.0, 600 mM NaCl, with 0.02 % Tween-20.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.; Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance. 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. Also acts as a myokine. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection. Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-6 superfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 天天爽夜夜爽人人爽一区二区 | 尤物网址在线观看| 天天看片天天av免费观看| 欧美日本日韩aⅴ在线视频| 少妇愉情理伦片bd| 中文字幕色av一区二区三区| 乱人伦xxxx国语对白| 久久综合狠狠综合久久综| 国产新婚夫妇叫床声不断| 精品国产一区二区三区av性色 | 性史性农村dvd毛片| 人妻另类 专区 欧美 制服| 亚洲另类欧美小说图片区| 国产亚洲精品a久久777777| 久久不见久久见免费影院www| 国产美女在线精品免费观看| 狠狠色综合久久丁香婷婷| 亚洲人成小说网站色| 国产免费无码一区二区三区| 好吊妞无缓冲视频观看| 亚洲综合区小说区激情区| 国色天香在线视频www| 精品人妻一区二区三区浪潮在线 | 国模冰莲极品自慰人体| 在线综合亚洲欧美日韩| 亚洲精品无码av人在线观看国产 | 人妻无码久久精品人妻| 中文乱码人妻系列一区| 无码人妻天天拍夜夜爽| 无码人妻aⅴ一区二区三区69岛 | 国产真实乱人偷精品视频| 亚洲精品无码久久毛片波多野吉衣 | 乱人伦人妻中文字幕无码久久网 | 国产精品久久久久久麻豆一区| 国产成人毛片无码视频软件| 蜜臀av性久久久久蜜臀aⅴ| 久久亚洲国产精品成人av秋霞 | 最新国产精品无码| 精品国产污污免费网站入口 | 色五月激情五月| 久久成人国产精品免费|