在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Macaca mulatta Interleukin-6 protein (IL6)

In Stock
  • 中文名稱:
    獼猴IL6重組蛋白
  • 貨號:
    CSB-AP003101MOW
  • 規格:
    ¥2124
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >97% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg.
  • 基因名:
  • Uniprot No.:
  • 別名:
    IL6Interleukin-6; IL-6
  • 種屬:
    Macaca mulatta (Rhesus macaque)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.Coli
  • 分子量:
    21.1 kDa
  • 表達區域:
    28-212aa
  • 氨基酸序列
    M+APVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from a 0.2 μm filtered concentrated solution in 50 mM Tris-HCl, pH9.0, 600 mM NaCl, with 0.02 % Tween-20.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.; IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury. In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.; Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance. 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. Also acts as a myokine. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection. Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-6 superfamily
  • 數據庫鏈接:


主站蜘蛛池模板: 麻花豆传媒剧国产免费mv入口| 曰本av中文字幕一区二区| 18禁超污无遮挡无码免费动态图| 香蕉久久精品日日躁夜夜躁夏| 伊伊人成亚洲综合人网7777| 粗大挺进尤物人妻中文字幕 | 欧美黑人巨大videos精品男男| 欧美日韩国产中文高清视频| 免费精品国产自在| 亚洲美女又黄又爽在线观看 | 国产日产欧产美| 亚洲婷婷综合色香五月| 免费网禁国产you女网站下载| 区二区三区国产精华液区别大吗| 一二三四社区在线中文视频 | 国产精成人品一区| 77se77亚洲欧美在线| 国产熟女高潮视频| 97精品国产一区二区三区| 狠狠躁夜夜躁人人爽蜜桃| 水蜜桃精品一二三| 国产午夜福利在线观看视频_| 久久久亚洲精品一区二区三区浴池| 99精品免费久久久久久久久日本| 小雪好紧好滑好湿好爽视频 | 国产午夜福利小视频合集| 中文字幕亚洲情99在线| 一区二区三区在线 | 网站| 久久人人97超碰爱香蕉| 青青草国产免费久久久下载| 欧美成a人片在线观看久| 国产精品亚洲一区二区三区| 97色成人综合网站| 中文字幕精品一区二区2021年 | 久久亚洲美女精品国产精品| 非洲黑人性xxxx精品| 高潮迭起av乳颜射后入| 亚洲va国产va天堂va久久| 国产成人午夜福利在线观看| 亚洲大码熟女在线观看| 亚洲午夜成人av电影|