在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Interleukin-36 beta (IL36B) (Active)

In Stock
  • 中文名稱:
    人IL36B重組蛋白
  • 貨號:
    CSB-AP002011HU
  • 規格:
    ¥2124
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >97% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The specific activity is determined by its binding ability in a functional ELISA. Immobilized rHuIL-36β at 1 ug/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 ug/mL.
  • 基因名:
    IL36B
  • Uniprot No.:
  • 別名:
    2310043N20Rik; Family of interleukin 1 eta; FIL1 (ETA); FIL1; FIL1 eta; FIL1H; FILI-(ETA); IL 1F8 (FIL1 eta; IL 1F8; IL 1H2; IL-1 eta; IL-1F8; IL-1H2; IL1 ETA; IL1F8 (Canonical product IL 1F8a); IL1F8; IL1F8_HUMAN; IL1H2; IL36 beta; IL36B; Interleukin 1 family, member 8 (eta); Interleukin 1 family, member 8; Interleukin 1 homolog 2; Interleukin 1 Superfamily e; Interleukin 36 beta; Interleukin-1 eta; Interleukin-1 family member 8; Interleukin-1 homolog 2; MGC126880; MGC126882; OTTMUSP00000012797; RP23-176J12.1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Isoform 2
  • 來源:
    E.Coli
  • 分子量:
    17.7 kDa
  • 表達區域:
    1-157aa
  • 氨基酸序列
    MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN MVYLGIKGKD LCLFCAEIQG KPTLQLKEKN IMDLYVEKKA QKPFLFFHNK EGSTSVFQSV SYPGWFIATS TTSGQPIFLT KERGITNNTN FYLDSVE
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.
  • 基因功能參考文獻:
    1. IL-36-mediated IL-6 and CXCL8 production in human lung fibroblasts and bronchial epithelial cells may be involved in pulmonary inflammation especially caused by bacterial or viral infections. PMID: 28869889
    2. With a focus on the skin as a target for microbial and viral invasion, the current knowledge of IL-36: IL-36alpha, IL-36beta and IL-36gamma, functions is reviewed. One physiological function of the IL-36smay be to counteract microbial immune evasion. [Review] PMID: 28811383
    3. IL36B expression is induced in keratinocytes by Toll-like receptor ligands suggesting a function in barrier immune defense. PMID: 22318382
    4. IL-1F8 functions as an inducer of antimicrobial peptide and matrix metalloproteinase expression by keratinocytes; IL-1F8 is overexpressed in transgenic psoriatic model mouse skin. PMID: 21242515
    5. IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells PMID: 14734551
    6. Joint and serum IL-1F8 protein levels did not correlate with inflammation, but they were high in samples from patients with rheumatoid arthritis PMID: 16646978

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Secreted.
  • 蛋白家族:
    IL-1 family
  • 組織特異性:
    Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy
  • 數據庫鏈接:

    HGNC: 15564

    OMIM: 605508

    KEGG: hsa:27177

    STRING: 9606.ENSP00000259213

    UniGene: Hs.278909



主站蜘蛛池模板: 日本熟妇浓毛hdsex| 国产在线观看免费人成视频| 琪琪午夜伦埋影院77| 情人伊人久久综合亚洲| 国产精品人人妻人人爽| 成年性午夜无码免费视频| 亚洲.欧美.在线视频| 精品国产三级a∨在线| 99国产精品久久久久久久成人| 国内精品久久久久影院老司机| 无码视频免费一区二区三区| 在线观看的av网站| 久久久噜噜噜久久中文字幕色伊伊| 亚洲最大av一区二区三区| 青青草99久久精品国产综合| 66亚洲一卡2卡新区成片发布| 老妇肥熟凸凹丰满刺激| 小说区 综合区 首页| 日韩不卡1卡2卡三卡2021精品推荐 | 日本三级吃奶头添泬| 尤物色综合欧美五月俺也去 | 中文字幕乱码一区二区免费| 337p日本欧洲亚洲大胆精品| 国产强被迫伦姧在线观看无码| 国产农村乱人伦精品视频| 少妇被又大又粗又爽毛片| 免费观看美女裸体网站| 国产精品乱码一区二区三区| 国产精品鲁鲁鲁| 亚洲一区二区三区中文字幕在线| 中文国产成人精品久久不卡 | 一区二区三区乱码在线 | 欧洲| 国产免费艾彩sm调教视频| 亚洲欧洲成人av每日更新| 精品久久久无码中文字幕一丶| 亚洲中文字幕无码久久| 男阳茎进女阳道视频大全| 国产清纯在线一区二区www| 精品国产成人网站一区在线| 午夜片无码区私人影院 | 欧美做受又硬又粗又大视频|