在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Neuritin protein (NRN1)

In Stock
  • 中文名稱:
    人NRN1重組蛋白
  • 貨號:
    CSB-AP002941HU
  • 規格:
    ¥852
  • 圖片:
  • 其他:

產品詳情

  • 純度:
    >97% as determined by SDS-PAGE.
  • 內毒素:
    Less than 1.0 EU/μg as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by by a cell proliferation assay using rat C6 cells is less than 25 ng/ml, corresponding to a specific activity of >4.0x104 IU/mg.
  • 基因名:
    NRN1
  • Uniprot No.:
  • 別名:
    Neuritin 1; Neuritin; NRN; Nrn1; NRN1_HUMAN; OTTHUMP00000015989; RP3 380B8.2 protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 來源:
    E.Coli
  • 分子量:
    9.7 kDa
  • 表達區域:
    28-115aa
  • 氨基酸序列
    AGKCDAVFKG FSDCLLKLGD SMANYPQGLD DKTNIKTVCT YWEDFHSCTV TALTDCQEGA KDMWDKLRKE SKNLNIQGSL FELCGSGN
  • 蛋白標簽:
    Tag-Free
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    0.2 μm filtered PBS, pH 7.4 ,lyophilized
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    5-10 business days
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells.
  • 基因功能參考文獻:
    1. NRN1 is expressed more extensively in melanoma than in normal melanocytes and healthy tissue. Secreted NRN1 seems to play a role also in earlier phases of melanoma development as we can discover NRN1 over-expression to be associated to primary melanoma PMID: 27901477
    2. results suggest that DTNBP1 and NRN1 genes show a joint effect on the risk for schizophrenia spectrum disorders. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate signalling suggests that our findings could be of value as a link to the schizophrenia aetiology. PMID: 27855309
    3. NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF. PMID: 28107668
    4. On analysis of the expression of NRN1 in SMA patients for the first time, NRN1 could be a potential modifier gene PMID: 27279027
    5. Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons. PMID: 27307045
    6. (i) NRN1 variability is a shared risk factor for both schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD. PMID: 26700405
    7. Data indicate that neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells PMID: 26208391
    8. Neuritin is reduced in the brains of Alzheimer's disease (AD) patients. PMID: 25101829
    9. MiR-204 promotes apoptosis in oxidative stress-induced rat Schwann cells by suppressing neuritin expression PMID: 25036738
    10. we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma PMID: 20405246
    11. Data show that SMN and HuD form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons. PMID: 21652774
    12. NRN1 polymorphisms have roles in fluid intelligence in schizophrenia PMID: 19569075
    13. CPG15 and CPG15-2 perform similar cellular functions but may play distinct roles in vivo through their cell-type- and tissue-specific transcriptional regulation PMID: 18265009

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor. Cell junction, synapse.
  • 蛋白家族:
    Neuritin family
  • 數據庫鏈接:

    HGNC: 17972

    OMIM: 607409

    KEGG: hsa:51299

    STRING: 9606.ENSP00000244766

    UniGene: Hs.103291



主站蜘蛛池模板: 在线播放国产精品三级网| 国产后入又长又硬| 人妻无码久久久久久久久久久| 无码av免费网站| 久久精品国产99国产精品亚洲 | 亚洲爱婷婷色婷婷五月| 美女露全乳无遮掩视频| 青青草无码免费一二三区 | 亚洲乱码在线卡一卡二卡新区豆瓣| 亚洲第一天堂无码专区| 日本免费一区二区三区| 极品少妇被啪到呻吟喷水| 久久精品农村毛片| 精品四虎国产在免费观看| 无码专区无码专区视频网址| 国产精品一区二区av不卡| 日本肉体xxxx裸交| 中文乱码免费一区二区| 中文字幕亚洲男人的天堂网络| 国产综合久久久久久鬼色| 精品国产a∨无码一区二区三区| 掀开奶罩边吃边摸下娇喘视频| 久久久噜噜噜久久熟女色| 国产成人无码av一区二区| 特级精品毛片免费观看| 中文字幕v亚洲ⅴv天堂| 久久精品国产一区二区免费| 国产成人毛片在线视频| 国产精品白浆无码流出| 少妇内射兰兰久久| 蜜臀色欲av在线播放国产日韩| 2018天天拍拍天天爽视频| 少妇扒开粉嫩小泬视频| 国产亚洲精品欧洲在线视频| h漫全彩纯肉无码网站| 国产成人无码精品久久久露脸| 99re6在线视频精品免费 | 羞羞视频在线观看| 成人国产一区二区三区精品不卡 | 一道久久爱综合久久爱| 爱性久久久久久久久|