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  4. Rat macrophage inflammatory protein 2,MIP-2 ELISA kit

Rat macrophage inflammatory protein 2,MIP-2 ELISA kit

  • 中文名稱：
    大鼠巨噬細胞炎性蛋白2(MIP-2)酶聯免疫試劑盒
  • 貨號：
    CSB-E07419r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠巨噬細胞炎性蛋白2(MIP-2)酶聯免疫試劑盒（CSB-E07419r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的CXCL2含量。CXCL2是重要靶點。它屬于趨化因子家族，在炎癥反應、腫瘤微環境等中起關鍵作用。其研究機制主要圍繞與受體結合，介導細胞趨化和激活，影響免疫細胞招募、腫瘤細胞遷移與增殖，目前是炎癥性疾病和腫瘤治療研究熱點。試劑盒檢測范圍為78 pg/mL-5000 pg/mL，靈敏度為19.5 pg/mL。適用于科研領域中對炎癥機制、藥物干預效果及疾病動物模型的研究，例如通過檢測組織勻漿中的MIP - 2水平評估局部炎癥程度，或分析血液樣本中趨化因子動態變化以探索全身性炎癥反應的調控通路。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Cxcl2 ELISA kit; Cinc3 ELISA kit; Mip-2 ELISA kit; Mip2 ELISA kit; Scyb2C-X-C motif chemokine 2 ELISA kit; Cytokine-induced neutrophil chemoattractant 3 ELISA kit; CINC-3 ELISA kit; Macrophage inflammatory protein 2 ELISA kit; MIP2 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    78 pg/mL-5000 pg/mL
  • 靈敏度：
    19.5 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of rat MIP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    88

    Range %

    80-95

    1:2

    Average %

    90

    Range %

    85-99

    1:4

    Average %

    98

    Range %

    94-101

    1:8

    Average %

    93

    Range %

    86-98

  • 回收率：

    The recovery of rat MIP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    95

    89-98

    EDTA plasma (n=4)

    89

    84-97

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    5000

    2.899

    2.934

    2.916

    2.778

    2500

    2.437

    2.567

    2.502

    2.364

    1250

    1.817

    1.828

    1.822

    1.684

    625

    1.228

    1.229

    1.229

    1.091

    312

    0.736

    0.721

    0.729

    0.591

    156

    0.445

    0.453

    0.449

    0.311

    78

    0.263

    0.254

    0.259

    0.121

    0

    0.141

    0.135

    0.138

    　

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展：
    CXCL2是介導中性粒細胞、嗜酸性粒細胞和巨噬細胞趨化的重要化學趨化因子。最新研究表明，CXCL2在許多炎癥疾病中起重要作用，如哮喘、炎性腸病、骨關節炎等。此外，CXCL2還參與了腫瘤發生、發展和轉移過程，是潛在的抗腫瘤治療靶點。
  • 功能：
    Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation.
  • 基因功能參考文獻：
    1. this study shows elevated expression of CINC-3 at the site of inflammation as well as their significant reflection in the circulation, thereby suggesting their frontline role in carrageenan-induced acute inflammation PMID: 27967265
    2. rutin is a potential protective agent in spinal cord injury enhancing the neurotrophic effect by inhibiting the expression of MIP-2 and activation of MMP-9, and downregulating the expression of p-Akt. PMID: 26502930
    3. The rat spiral ligament fibrocytes were found to release CXCL2 in response to nontypeable H. influenzae via activation of c-Jun, leading to the recruitment of polymorphonuclear cells to the cochlea. PMID: 22379036
    4. CsA has no significant effect on serum levels of MCP-1 and MIP-2 following renal transplantation in rats. PMID: 20034917
    5. Results identify FQHPSFI peptide may be used for the modulation of lipopolysaccharide-stimulated MIP-2 production in alveolar macrophagess. PMID: 20186460
    6. chemokine production by rat alveolar macrophages is inhibited by taurine chloramine PMID: 11716962
    7. Intratracheal LPS induced a significant increase in MIP-2 in bronchoalveolar lavage (BAL) fluid with no detectable MIP-2 in the plasma. PMID: 11837784
    8. demonstrated that the beta-glucan component of the Pneumocystis carinii cell wall is able to stimulate alveolar epithelial cells to produce MIP-2 PMID: 11906040
    9. role for the nitric oxide pathway in the overproduction of pro-inflammatory mediators IL-6 and MIP-2 during GBS-induced lung inflammation. PMID: 12661899
    10. junctional epithelium cells produced MIP-2 and CINC-2 in response to LPS stimulation, suggesting that MIP-2 and CINC-2 may be responsible for PMN migration toward the periodontal pathogen and may play an important role in the initiation of inflammation PMID: 15045510
    11. macrophage inflammatory protein 2 mediates platelet-activating factor-induced intestinal injury PMID: 15319184
    12. no significant differences were detected for MIP-2 levels in diabetic rats when compared with non-diabetic rats after hypoxia PMID: 16132691
    13. Following cecal ligation and puncture Cxcl2 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. PMID: 16818791
    14. MIP-2/CXCL2 and MCP-1/CCL2 are increased after injury, and neurons appear to be the source of this expression. Chemokine expression was selectively inhibited by dexamethasone. PMID: 19210118

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine alpha (chemokine CxC) family
  • 組織特異性：
    At least expressed in the lung and trachea.
  • 數據庫鏈接：


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