在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat heparin-binding EGF-like growth factor (HBEGF) ELISA kit

Rat heparin-binding EGF-like growth factor (HBEGF) ELISA kit

  • 中文名稱：
    大鼠肝素結合EGF樣生長因子(HBEGF)酶聯免疫試劑盒
  • 貨號：
    CSB-EL010154RA
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠肝素結合EGF樣生長因子(HBEGF)酶聯免疫試劑盒（CSB-EL010154RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的HBEGF含量。HBEGF是一種重要的靶點。它是表皮生長因子家族成員，在細胞生長、增殖和遷移等過程中發揮作用。研究聚焦于其在腫瘤發生、發展中的機制，比如促進腫瘤細胞生長、侵襲和轉移等，有望為癌癥等疾病治療提供新方向。試劑盒檢測范圍為6.25 pg/mL-400 pg/mL，該產品適用于科研領域研究HBEGF在肝損傷、心血管疾病或腫瘤模型中的表達調控機制，例如通過檢測肝纖維化模型中組織勻漿HBEGF水平變化，或分析藥物干預后血漿因子動態變化，為探索HBEGF相關信號通路及疾病機理提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Hbegf; Dtr; Hegfl; Proheparin-binding EGF-like growth factor
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    6.25 pg/mL-400 pg/mL
  • 靈敏度：
    1.56 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat HBEGF in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 104
    Range % 91-108
    1:2 Average % 100
    Range % 91-105
    1:4 Average % 94
    Range % 87-99
    1:8 Average % 98
    Range % 90-103
  • 回收率：
    The recovery of rat HBEGF spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 89 81-95
    EDTA plasma (n=4) 102 95-107
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    400 2.727 2.586 2.657 2.537
    200 2.229 2.179 2.204 2.084
    100 1.452 1.428 1.440 1.320
    50 0.739 0.727 0.733 0.613
    25 0.423 0.411 0.417 0.297
    12.5 0.268 0.261 0.265 0.145
    6.25 0.182 0.175 0.179 0.059
    0 0.118 0.122 0.120 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
  • 基因功能參考文獻：
    1. Heterotrimeric G proteins directly regulate membrane-localized MMP14/MT1-MMP, resulting in HB-EGF release and EGFR transactivation. PMID: 25759388
    2. HB-EGF promotes hepatic stellate cell proliferation via activation of the EGFR and ErbB4 receptors PMID: 24303948
    3. FAK phosphorylation and FAK-mediated signal transduction play essential roles in HB-EGF-mediated intestinal epithelial cell migration and adhesion. PMID: 24703506
    4. Intraluminal administration of HB-EGF reduces the severity of intestinal congestion/repurfusion(C/R) injury in rats. PMID: 23534509
    5. HB-EGF induces cardiomyocyte hypertrophy through an EGFR-ERK5-MEF2A-COX-2 pathway. PMID: 21244855
    6. There were no significant changes in HB-EGF mRNA or protein expression in either the plantaris or the soleus in response to functional overload. PMID: 20696782
    7. HB-EGF contributes to vascular remodeling. PMID: 11882602
    8. HB-EGF expressed in proximity to developing mesencephalic dopaminergic neurons promotes their survival in vitro. HB-EGF may be an important molecule for developing dopaminergic neurons of the ventral midbrain. PMID: 11956950
    9. data indicate HB-EGF gene expression can be regulated by Cdx2 in intestinal epithelial (IEC-6) cells PMID: 12223343
    10. Data suggest that the interaction between HB-EGF and EGFR transactivation is closely related to the proliferation of cardiac fibroblasts and cardiac remodeling after myocardial infarction. PMID: 12237129
    11. HB-EGF mRNA expression and protein production in intestine undergoing ischemia/reperfusion injury PMID: 12746188
    12. Chelerythrine stimulated production of reactive oxygen species, and antioxidants prevented chelerythrine-induced HB-EGF shedding, suggesting that the production of intracellular peroxides is necessary for this event PMID: 15490481
    13. analysis of clearance of HB-EGF in adult and newborn rats PMID: 16364500
    14. 5-HT2A receptor induces ERK phosphorylation and proliferation through TACE enzyme activation and HB-EGF shedding in mesangial cells PMID: 16737974
    15. extracellular superoxide dismutase is related to the epidermal growth factor (EGF) signaling in two ways, competition for HSPG with heparin-binding-EGF and as an ROS scavenger PMID: 16753836
    16. It is suggested that the increased expression of HB-EGF and the inhibition of glial cell swelling may be parts of a protective role of HB-EGF in the ischemic retina. PMID: 16806064
    17. Juxtacrine activation of EGFR by membrane-anchored HB-EGF may play an important role in the regulation of tight junction proteins and transepithelial resistance. PMID: 17855771
    18. Collectively, these data demonstrate that membrane-anchored HB-EGF is targeted to the inner nuclear membrane via a retrograde membrane trafficking pathway. PMID: 18299347
    19. Pro-inflammatory stimuli induce the release of HB-EGF from mesenchyme cells, which stimulates DNA-replication in initiated/premalignant hepatocytes PMID: 18929421
    20. rapid HA accumulation after epidermal wounding occurs through a mechanism requiring cleavage of HB-EGF and activation of EGFR signaling. PMID: 19225541
    21. mechanical stretch promotes fetal type II cell differentiation via ectodomain shedding of HB-EGF and TGF-alpha PMID: 19237431
    22. Hbegf is a potent dilator of terminal mesenteric arterioles. PMID: 19389413

    顯示更多

    收起更多

  • 亞細胞定位：
    [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Most abundant in skeletal muscle, lung, spleen brain and heart.
  • 數據庫鏈接：


主站蜘蛛池模板： 凹凸精品熟女在线观看| 日本一卡2卡3卡四卡精品网站 | 98国产精品综合一区二区三区| 日日拍夜夜嗷嗷叫|日日摸| 美日欧激情av大片免费观看| 国产女人乱子对白av片| 国产午夜精品av一区二区| 性生交大片免费看l| 国产av无码专区亚洲草草| 欧美人与动性xxxxx交性| 亚洲v欧美v国产v在线观看| 日本新janpanese乱熟| 强制高潮18xxxx按摩| 国产精品亚洲a∨天堂不卡| 东京热人妻中文无码av| 国产猛男猛女超爽免费视频| 饥渴丰满少妇大力进入| 午夜福利精品导航凹凸| 国产成a人亚洲精品无码久久网| 国语精品福利自产拍在线观看| 午夜内射中出视频| 亚洲老熟女性亚洲| 亚欧美无遮挡hd高清在线视频| 2020精品自拍视频曝光| 亚洲一本一道一区二区三区| 日韩精品无码一区二区三区久久久 | 久久国产欧美日韩精品| 人妻少妇被粗大爽.9797pw| 欧洲精品va无码一区二区三区| 老司机午夜福利av无码特黄a| 欧美老人巨大xxxx做受视频| 女人爽到喷水的视频大全| 精品久久久久久久国产潘金莲| 后入内射无码人妻一区| 香蕉免费一区二区三区在 | 少妇放荡的呻吟干柴烈火免费视频 | 国产精品久久久久久久久久| 新狼窝色av性久久久久久| 一道精品视频一区二区三区| 日韩人妻中文无码一区二区三区| 永久免费看mv网站入口亚洲|