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Rat growth-regulated oncogene α/melanoma growth stimulating activity,GROα /MGSA Elisa Kit

  • 中文名稱:
    大鼠生長調節致癌基因α/黑素瘤生長刺激因子(GROα/CXCL1/MGSA)酶聯免疫試劑盒
  • 貨號:
    CSB-E12997r-IS
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 別名:
    Cxcl1 ELISA Kit; Cinc1 ELISA Kit; Gro ELISA Kit; Scyb1Growth-regulated alpha protein ELISA Kit; C-X-C motif chemokine 1 ELISA Kit; Cytokine-induced neutrophil chemoattractant 1 ELISA Kit; CINC-1 ELISA Kit; Platelet-derived growth factor-inducible protein KC ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
    serum, plasma, cell culture supernates, tissue homogenates
  • 檢測范圍:
    7.8pg/mL-500pg/mL
  • 靈敏度:
    3.9pg/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Immunology
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days.

產品評價

靶點詳情

  • 功能:
    Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation.
  • 基因功能參考文獻:
    1. The results showed that after short-term incubation both CXCL1 and CXCL2 can activate TRPV1+/IB4+ DRG neurons by significantly reducing TRPV1 desensitization, while at acute application both chemokines induced an increase in [Ca2+]i although of different amplitudes, in a subset of neurons partially also itch-sensitive in the case of CXCL1, or non-itch sensitive in the case of CXCL2. PMID: 28820395
    2. remote ischemic preconditioning protects hepatic microcirculation by induction of HO and modulation of cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury PMID: 27672274
    3. Results results demonstrate that sphingosine-1-phosphate induces Ca(2+) signaling in astrocytes via Gq -coupled receptors S1P2 and S1P3 , followed by Ca(2+) influx through TRPC6 that could activate MAPK signaling, which leads to increased secretion of the proinflammatory or neuroprotective chemokine CXCL1 PMID: 28300348
    4. aging can reduce the expression of CINC and MCP-1 mRNA in lung tissues, and reduce the infiltration of neutrophils and monocyte-macrophages induced by CINC and MCP-1. This might lead to increased risk of pneumonia in elderly patients. PMID: 24464584
    5. In opioid-tolerant rats, CXCL1 is up-regulated in CSF; as it is in patients also. PMID: 25383568
    6. Function of the transient receptor potential vanilloid (TRPV)1 channel is enhanced by dorsal root ganglia inflammation. The effects (decreased tachyphylaxis) are mimicked by incubation with GRO/KC. PMID: 22466126
    7. CXCL1 inhibition of oligodendrocyte progenitor cell migration is regulated via changes in intracellular calcium flux. PMID: 22554866
    8. hyperoxia exposure led to a suppression of the HDAC1/HDAC2 expression and activity, and the overall HDAC activity, as well as arrest of alveolarization, and an elevated expression of CINC-1 in the lungs of newborn rats PMID: 21905265
    9. Advanced glycation end products promote the secretion of MCP-1 and IL-8 in vascular smooth muscle cells. PMID: 21418993
    10. Severe burn injury activates pulmonary NF-kappaB and leads to secretion of IL8 and TNF alpha in the lung. PMID: 17959522
    11. In rats with chronic nonbacterial prostatitis, the levels of TNF-alpha and IL-8 in the serum and prostate tissues were significantly lower in the curcumin-treated group than in the positive control group. PMID: 20180411
    12. ATP-stimulated C6 glioma cells showed enhanced expression of MCP-1 & IL-8; elevated levels of MCP-1 & IL-8 are predicted to enhance mobility of tumor cells & promote recruitment of microglia into developing tumors thereby supporting tumor growth. PMID: 20003523
    13. These results suggest that IL-6 and CINC-1 contribute to alpha2M production in rats only when IL-6 and CINC-1 act synergistically. PMID: 21030786
    14. The decreased serum concentration of CINC-1 as neuroprotective agent and increased CINC-2alpha in late stage of Morris hepatoma may be considered for their contribution to cerebellar degeneration. PMID: 20602290
    15. Rats treated with fullerenes showed a transient significant increase of neutrophils and expression of CINC-1,-2alphabeta and -3. PMID: 20226088
    16. CINC-1, released at sites of inflammation, mediates inflammatory hyperalgesia in rats via release of sympathomimetic amines. PMID: 12517731
    17. CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues PMID: 12709409
    18. neutrophil migration induced by IL-8 is dependent on CINC-1 release from mast cells PMID: 12824006
    19. Data show that TII alveolar epithelial cells produce three of the major proinflammatory CXC chemokines (GRO, CINC-2alpha, and MIP-2) and their cognate receptor CXCR2. PMID: 12829448
    20. CINC, in contrast to MIP-2, is selectively transported from the lung to the systemic circulation, where it promotes neutrophil migration into the lung in response to a chemotactic stimulus. PMID: 14617513
    21. reactive oxygen species and lipid peroxidation mainly derived from neutrophils, which are stimulated and mobilized by TNF-alpha and cytokine-induced neutrophil chemoattractant-1 PMID: 15942680
    22. CINC-1 may contribute to liver repair and regeneration PMID: 16271365
    23. In summary, hyperalgesia, local PGE2 production, and spinal c-Fos expression occur after CFA-induced inflammation but not after CXCL1- or CXCL2/3-induced, selective PMN recruitment. PMID: 16522746
    24. results demonstrate that ascorbic acid deficiency elevates the serum, liver and spleen concentrations of cytokine-induced neutrophil chemoattractant-1 (CINC-1 as seen in acute inflammation PMID: 16637227
    25. Following cecal ligation and puncture CINC-1 production increases in the lung, setting the stage for neutrophil accumulation in lung during sepsis. PMID: 16818791
    26. activation of PAR-2, as well as PAR-1, can rescue astrocytes from ceramide-induced apoptosis via regulating chemokine GRO/CINC-1 release. PMID: 16942465
    27. berberine dose-dependently inhibited the expression of CINC-1 induced by LPS and diminished the anterior uveitis. PMID: 17164575
    28. TNFalpha has in different forms of arthritis, but points out the idea that CINC-1 (the homologue for human IL-8) may constitute a promising target for reactive arthritis management PMID: 17166735
    29. basal level of calcium is the pre-requisite for GRO/CINC-1 protein synthesis and secretion PMID: 17666044
    30. Induction of CXCL1 by extracellular matrix and autocrine enhancement by interleukin-1 in rat pancreatic beta-cells. PMID: 17702850
    31. GGA effectively suppressed the up-regulation of GRO1 messenger ribonucleic acid, and this was validated by Northern hybridization. PMID: 18683011
    32. This is the first time that centrally injected CINC-1 has been reported to act directly on the pyrogen-sensitive neurons of the preoptic area, promoting a thermoregulatory response that seems to depend on other endogenous pyrogens synthesis and PGE2. PMID: 18694739
    33. CXCL1 incubation (1.5 nM, overnight) caused marked upregulation of Na+ currents in acutely isolated small diameter rat (adult) sensory neurons in vitro. PMID: 18816377
    34. The results suggest that GRO/KC has important effects in inflammatory processes via its direct actions on sensory neurons. PMID: 19476648
    35. CINC-1 is a neutrophil chemoattractant; findings have established that CINC-1 also functions as an early acute-phase protein after injury to the brain or to peripheral tissues. PMID: 12709409

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  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Intercrine alpha (chemokine CxC) family
  • 組織特異性:
    At least expressed in the lung and trachea.
  • 數據庫鏈接:


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