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Rat Superoxide dismutase [Mn], mitochondrial(SOD2) ELISA kit

  • 中文名稱:
    大鼠超氧化物歧化酶[錳],線粒體(SOD2)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-EL022398RA
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    大鼠超氧化物歧化酶[錳],線粒體(SOD2)酶聯(lián)免疫試劑盒(CSB-EL022398RA)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的SOD2含量。SOD2(超氧化物歧化酶2)是一種線粒體酶,主要功能是清除細(xì)胞內(nèi)的超氧陰離子自由基,保護(hù)細(xì)胞免受氧化損傷。它在多種疾病中扮演重要角色,包括癌癥。近期研究發(fā)現(xiàn),SOD2在乳腺癌中可能發(fā)揮雙重作用,即早期作為腫瘤抑制因子,晚期作為腫瘤促進(jìn)劑,其作用機(jī)制可能與JAK-STAT信號通路相關(guān)。試劑盒檢測范圍為1.87 pg/mL-120 pg/mL,適用于基礎(chǔ)研究中對氧化應(yīng)激相關(guān)模型的分子機(jī)制解析、藥物干預(yù)效果評估或疾病生物標(biāo)志物探索等科研場景,為心血管、神經(jīng)系統(tǒng)及代謝領(lǐng)域的研究提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    Sod2 ELISA Kit; Superoxide dismutase [Mn] ELISA Kit; mitochondrial ELISA Kit; EC 1.15.1.1 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    1.87 pg/mL-120 pg/mL
  • 靈敏度:
    0.47 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Metabolism
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of rat SOD2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1000Average %89
    Range %84-92
    1:2000Average %95
    Range %91-98
    1:4000Average %88
    Range %84-91
    1:8000Average %99
    Range %93-102
  • 回收率:
    The recovery of rat SOD2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9087-93
    EDTA plasma (n=4)10198-104
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    1202.427 2.398 2.413 2.307
    601.887 1.862 1.875 1.769
    301.449 1.402 1.426 1.320
    150.803 0.813 0.808 0.702
    7.50.492 0.466 0.479 0.373
    3.750.292 0.287 0.290 0.184
    1.870.202 0.213 0.208 0.102
    00.107 0.105 0.106
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

引用文獻(xiàn)

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
  • 基因功能參考文獻(xiàn):
    1. The SIRT3-SOD2 signaling pathway is involved in mitochondrial dysfunction induced by hemorrhagic shock PMID: 27067422
    2. These benefits appear to be attributed to the enhanced interaction between STAT3 and MnSOD. These findings shed a light on a new role of STAT3 in oxidative stress and suggest that ZYZ451 is likely an effective cardio-protective agent. PMID: 26721595
    3. SOD2 mediates amifostine-induced protection in PC12 cells exposed to glutamate. PMID: 26770652
    4. Selective upregulation of SOD2 in the left ventricles of rat hearts during L-NAME induced heart failure. PMID: 25978844
    5. SOD2 might regulate neuroinflammation by controlling the microglial activities. PMID: 26231211
    6. Study demonstrated that knockdown of MnSOD in vitro leads to reactive oxygene species generation as well as induction of functional mitochondrial biogenesis. PMID: 24563852
    7. Data indicate a functionally active mitochondrial pool of p38beta mitogen activated protein kinase (p38beta MAPK), and that this kinase phosphorylates manganese superoxide dismutase (MnSOD) in an 17beta-estradiol (E2)-dependent manner. PMID: 24465521
    8. Data suggest that expression of mitochondrial MnSOD/Sod2 (and CuZnSOD/Sod1) is down-regulated as retinal neurons undergo apoptosis following onset of diabetes/diabetic retinopathy. PMID: 24527463
    9. miR-146a could down-regulate the SOD2 protein expression. PMID: 23935993
    10. Hyperbaric oxygen therapy alters SOD2 protein and mRNA levels after brain injury in a time-dependent manner. PMID: 23275324
    11. The present findings suggest that oxidative stress occurring in the brain of immature rats during and following the seizures induced by DL-HCA is apparently due to both the increased free radical production and the limited antioxidant defense. PMID: 23238024
    12. Down-regulation of Mn-SOD expression may play an important role in the aggravation of oxidative stress in endemic fluorosis. PMID: 23157833
    13. SOD2 protects cardiac progenitor cells from apoptosis following xanthine/xanthine oxidase treatment. PMID: 22758933
    14. There was no difference in the expression of Mn-SOD between OLETF rats and LETO rats in type 2 diabetes. PMID: 22981416
    15. Data suggest that local overexpression of MnSOD in rat skeletal muscle in vivo (by electroporation to transfer the human gene) is sufficient to protect muscle against insulin resistance caused by oxidative stress of high-fat diet. PMID: 22829583
    16. Only the chronic administration of higher doses of alpha-tocopherol is associated with the increased activity and expression of Mn-SOD in rats. PMID: 22732938
    17. The increased expression of antioxidant SOD2, specifically in hippocampal neurons, will provide protection from age-related cognitive decline. PMID: 21942371
    18. Berry diets did not alter COX-2 levels, but blueberry diet significantly reduced MnSOD levels in rats with reflux-induced esophageal adenocarcinoma. PMID: 22043833
    19. Changes in Mn-superoxide dismutase expression in rat hippocampus induced by single and triple exposure to moderate hypobaric hypoxia PMID: 22171425
    20. Upregulation of MnSOD in the aging heart was directly associated with attenuated levels of oxidative stress, including iNOS. PMID: 19297546
    21. Cigarette smoke aggravates reflux-induced BE and potentially accelerates the progression of BE to EAC through the loss of manganese superoxide dismutase (MnSOD), and overexpression of NF-kappaB- and COX-2-mediated factors. PMID: 21506880
    22. Increased H4K20me3 at sod2 contributes to its downregulation and is important in the development of diabetic retinopathy and in the metabolic memory phenomenon. PMID: 21357467
    23. Results suggest that the upregulation of TNFalpha, NFkappaB and MnSOD after deafferentation in the vestibular nuclei may constitute a favorable neuronal environment for the vestibular compensation process. PMID: 21143912
    24. Apoptosis of the retinal neurons in early diabetic rats may correlate with the decline of the activity and mRNA expression of MnSOD. PMID: 20654064
    25. PGC-1alpha is induced by cerebral ischemia leading to upregulation of UCP2 and SOD2, thereby providing a neuroprotective effect against ischemic brain injury in the hippocampus by ameliorating oxidative stress PMID: 19774674
    26. Chronic stress isolation results in mitochondrial dysfunction and MnSOD release into the cytosol. PMID: 19893080
    27. Data highlight the role played by some residues in ratSOD2 and suggest a fine regulation of the enzyme occurring in vivo. PMID: 19384983
    28. MnSod has a role in improving neuronal survival after hypoxia/ischemia PMID: 12577622
    29. Mn-SOD may play a role in regulating ROS and matrix degradation involving mechanical deterioration of the stress-deprived tendon tissue PMID: 15375579
    30. MnSOD is not affected by acute stressors PMID: 16238459
    31. analysis of transcriptional regulation of the superoxide dismutase-2 kappaB element in rat embryonic neurons and astrocytes PMID: 17023425
    32. Experimental abdominal aortic aneurysm formation is associated with early increases in MnSOD expression PMID: 17196988
    33. loss of MnSOD protein contributes to the reduced level of its enzymatic activity and plays a key role in the induction of esophagitis PMID: 17349848
    34. upregulated in neurogenic hypertension PMID: 19047792
    35. both the proportion of SOD2 immunopositive type 1 spiral ganglion cells and the intensity of immunoreactivity were elevated near cochlear apex PMID: 19376215
    36. overexpression in renal proximal tubular cells prevents hyperglycemia-induced changes PMID: 19439219

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  • 亞細(xì)胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Iron/manganese superoxide dismutase family
  • 數(shù)據(jù)庫鏈接:


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