在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Rat Protein S100-A8(S100A8) ELISA kit

  • 中文名稱:
    大鼠S100-A8蛋白(S100A8)酶聯免疫試劑盒
  • 貨號:
    CSB-EL020641RA
  • 規格:
    96T/48T
  • 價格:
    ¥3600/¥2500
  • 其他:

產品詳情

  • 產品描述:
    大鼠S100-A8蛋白(S100A8)酶聯免疫試劑盒(CSB-EL020641RA)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿樣本中的S100A8含量。S100A8是一個值得關注的靶點。它在人體免疫等生理過程中發揮作用。研究機制方面,主要圍繞其在炎癥反應、腫瘤發生發展等過程里的信號傳導、細胞間相互作用等展開,明確它的功能有助于為相關疾病治療提供新思路。試劑盒檢測范圍為3.12 ng/mL-200 ng/mL,適用于科研領域中對炎癥機制、免疫調節通路或疾病模型(如關節炎、敗血癥等)的分子機制研究,也可用于藥物開發中靶向S100A8通路的療效評估本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
  • 別名:
    S100a8 ELISA Kit; Mrp8 ELISA Kit; Protein S100-A8 ELISA Kit; Calgranulin-A ELISA Kit; Migration inhibitory factor-related protein 8 ELISA Kit; MRP-8 ELISA Kit; p8 ELISA Kit; S100 calcium-binding protein A8 ELISA Kit
  • 縮寫:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 樣本類型:
    serum, plasma, tissue homogenates
  • 檢測范圍:
    3.12 ng/mL-200 ng/mL
  • 靈敏度:
    0.78 ng/mL
  • 反應時間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領域:
    Others
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 數據處理:
  • 貨期:
    3-5 working days

產品評價

相關問答

 常見問題解答
Q:

Per customers request, please provide the following information regarding Rat Protein S100-A8, S100A8 ELISA Kit (CSB-EL020641RA):
1) What is the Uniprot/Accession number that this kit is designed for? Is the kit designed for XYZ species or is it designed for a different species such as Human and cross reacts with XYZ species?
2) Is the capture antibody a monoclonal or polyclonal?
3) What is the host of the capture antibody?
4) What’s the immunogen or immunogen range of the capture antibody?
5) What’s is the species of the immunogen of the capture antibody, human or something else?
6) Is the detection antibody a monoclonal or polyclonal?
7) What is the host of the detection antibody?
8) What is the immunogen or immunogen range of the detection antibody?
9) What is the species of the immunogen of the detection antibody? Human or something else?
10) What’s is that standard? A recombinant protein or something else? If a recombinant protein, what is the host?
11) If recombinant protein, is it full length or partial?
12) What is the species of the standard– human or something else?
13) What sample type was tested with this kit (serum? plasma? Something else?) and what were the reference values.

A:
Thanks for your inquiry!
CSB-EL020641RA
This kit is designed according to: https://www.uniprot.org/uniprot/P50115.
Capture antibody is mouse monoclonal antibody and immunogen is NS0-derived recombinant protein, full length.
Detection antibody is goat polyclonal antibody and immunogen is NS0-derived recombinant protein, partial.
Standard is NS0-derived recombinant protein.
This kit is designed for rat. Although it has homology with the protein from other species, we don't suggest you use this kit to test other species because there is matrix interference.
We tested serum and plasma samples before and the test value is ND--12.5ng/ml.
Pls let me know if you have any further questions. Thank you.

靶點詳情

  • 功能:
    S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity.
  • 基因功能參考文獻:
    1. Establish S100A8 transgenic rats to elucidate role as a regulator in acute inflammation. PMID: 28913572
    2. Recombinant rat r-S100A8 bound to r-CD68. The expression levels of S100A8 were significantly suppressed after the macrophages had been treated with an anti-CD68 antibody. Small interfering CD68 also significantly suppressed activation of macrophages through an autocrine pathway by r-S100A8. PMID: 27312849
    3. results support S100A8 as a novel therapeutic target to control ASM contraction in asthma PMID: 28088518
    4. vagus nerve electrical stimulation may produce a protective effect on septic shock in rats by decreasing the production of S100A8. PMID: 27035526
    5. Expression of S100A8 mRNA and the corresponding protein in cultured NRVCs was similar between control cells and norepinephrine-stimulated cells, but was markedly upregulated at 12 hours after the withdrawal of NE. PMID: 25820336
    6. Mrp8 may potentiate the perpetuation of mesial temporal lobe epilepsy by activating the NF-kappaB pathway in astrocytes. PMID: 23982744
    7. Report role for MRP8 for exaggerated in-stent restenosis in diabetes mellitus type 2. PMID: 22381691
    8. In vivo zinc regulates S100A8 expression and modulates the link between S100A8-RAGE interaction and downstream nuclear factor kappaBeta/COX-2 signaling PMID: 19111725
    9. The bladder uroepithelium was a prominent cell source of S100A8-S100A9 in animals with complicated urinary tract infection, which was not detected in animals with asymptomatic urinary tract infection. PMID: 19667050

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.
  • 蛋白家族:
    S-100 family
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲在av极品无码| 久久99精品久久久久久久不卡| 奇米影视色777四色在线首页 | 狠狠综合久久久久尤物| 国产精品久久国产精麻豆99网站 | 137肉体摄影日本裸交| 精品少妇爆乳无码av无码专区| 人人插人人插人人爽| 蜜桃无码一区二区三区| 无码人妻丰满熟妇区免费| 伊人精品一本久久综合| av片亚洲国产男人的天堂| 日本www网站色情乱码| 成人影院yy111111在线观看| 久久天天躁夜夜躁狠狠85麻豆 | 国内揄拍国内精品人妻| 欧洲亚洲1卡二卡三卡2021| 偷窥村妇洗澡毛毛多| 国产一区二区三区不卡在线看| 亚洲精品黑牛一区二区三区| 情侣作爱视频网站| 国产99在线 | 亚洲| 日本精品αv中文字幕| 精品无人乱码高清| 无码一区二区三区av在线播放 | 久久婷婷香蕉热狠狠综合| 射死你天天日| 欧美 日韩 亚洲 在线| 97色伦综合在线欧美视频| 97精品尹人久久大香线蕉| 精品少妇爆乳无码av无码专区| 少妇邻居内射在线| 亚洲一区二区制服在线| 亚洲妇女自偷自偷图片| 四虎永久在线精品免费网站 | 日日摸日日碰夜夜爽av| 无码丰满熟妇| 欧美熟妇的性裸交| 成人爽a毛片免费看| 日韩国产综合精选| 欧洲精品99毛片免费高清观看|