Rat Mucin-4(MUC4) ELISA kit

產品詳情

產品描述：

大鼠粘蛋白-4(MUC4)酶聯免疫試劑盒（CSB-EL015227RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的MUC4含量。MUC4是一種跨膜黏蛋白，在多種惡性腫瘤中高表達。其背景上，與腫瘤的發生、發展及轉移密切相關。研究機制方面，它能參與細胞信號傳導，調節細胞黏附、增殖和凋亡等過程，還可影響腫瘤微環境，成為腫瘤治療有潛力的靶點。試劑盒檢測范圍為0.78 ng/mL-50 ng/mL，適用于科研領域中對呼吸道、消化道等黏膜相關疾病模型、腫瘤微環境研究或藥物干預實驗中MUC4蛋白動態變化的定量分析，為探索黏膜屏障功能調節機制及生物標志物研究提供可靠工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
別名：

Muc4; Smc; Mucin-4; MUC-4; Ascites sialoglycoprotein; ASGP; Pancreatic adenocarcinoma mucin; Pre-sialomucin complex; pSMC; Sialomucin complex; Testis mucin
縮寫：

MUC4
Uniprot No.：

Q63661
種屬：

Rattus norvegicus (Rat)
樣本類型：

serum, plasma, tissue homogenates
檢測范圍：

0.78 ng/mL-50 ng/mL
靈敏度：

0.195 ng/mL
反應時間：

1-5h
樣本體積：

50-100ul
檢測波長：

450 nm
研究領域：

Signal Transduction
測定原理：

quantitative
測定方法：

Sandwich
數據處理：

ELISA操作視頻及標曲繪制軟件下載
貨期：

3-5 working days

功能：

Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation.
亞細胞定位：

[Mucin-4 beta chain]: Cell membrane; Multi-pass membrane protein.; [Mucin-4 alpha chain]: Secreted.
組織特異性：

Expression is developmentally regulated in the mammary gland, dramatically increases in the lactating gland compared with the virgin mammary gland, while decreasing again during mammary gland involution. Expressed in 13762 ascites cells. Overexpressed in