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  4. Rat Interleukin 1 receptor antagonist, IL-1ra ELISA kit

Rat Interleukin 1 receptor antagonist, IL-1ra ELISA kit

  • 中文名稱：
    大鼠白介素1受體拮抗劑(IL1Ra)酶聯免疫試劑盒
  • 貨號：
    CSB-E10397r
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠白介素1受體拮抗劑(IL1Ra)酶聯免疫試劑盒（CSB-E10397r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IL1RN含量。IL1RN是重要靶點。它屬于白細胞介素-1受體拮抗劑，可競爭結合IL-1受體。背景上，其失衡與多種炎癥性疾病相關。研究機制方面，主要是通過阻斷IL-1信號通路，抑制炎癥反應，在炎癥疾病治療研究里具有重要價值。試劑盒檢測范圍為125 pg/mL-8000 pg/mL，適用于科研領域中對炎癥機制、自身免疫疾病模型或藥物干預效果的動態研究。為探索IL - 1信號通路調控、評估實驗動物體內抗炎反應強度提供了可靠工具，廣泛應用于基礎醫學、藥理學及生物標志物研究等領域。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Il1rn ELISA Kit; Il-1raInterleukin-1 receptor antagonist protein ELISA Kit; IL-1RN ELISA Kit; IL-1ra ELISA Kit; IRAP ELISA Kit; IL1 inhibitor ELISA Kit
  • 縮寫：
    IL1RN
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    125 pg/mL-8000 pg/mL
  • 靈敏度：
    31.25 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Others
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IL-1ra in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　SampleSerum(n=4)
    1:1Average %102
    Range %98-105
    1:2Average %97
    Range %92-102
    1:4Average %96
    Range %90-101
    1:8Average %93
    Range %88-99
  • 回收率：
    The recovery of rat IL-1ra spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 9792-104
    EDTA plasma (n=4)8982-95
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/mlOD1OD2AverageCorrected
    80002.259 2.269 2.264 2.148
    40001.554 1.597 1.576 1.460
    20001.040 1.068 1.054 0.938
    10000.625 0.672 0.649 0.533
    5000.398 0.371 0.385 0.269
    2500.279 0.274 0.277 0.161
    1250.181 0.189 0.185 0.069
    00.114 0.118 0.116 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
  • 基因功能參考文獻：
    1. IL-1beta is the key trigger of neuroinflammation and that IL-1ra prevents the neuroinflammation entering the chronic state PMID: 24621600
    2. Interleukin-1beta and interleukin-1 receptor antagonist appear in grey matter additionally to white matter during experimental multiple sclerosis PMID: 24376764
    3. Gene expression of the natural IL-1 receptor antagonist IL-1ra and IL-18 (but not TNFalpha) is increased in the ipsilateral hippocampus during long-term potentiation. PMID: 23747799
    4. the IL-1ra gene could be transferred and expressed in corneal tissue efficiently. This may be a novel technique for gene transfection to the cornea in situ. PMID: 22827713
    5. Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. PMID: 22117073
    6. IL1Ra has a role in reducing islet endothelial activation and oxidative stress gene expression in the GK diabetic rat PMID: 19742300
    7. IL-1ra, even when applied for only 4 h, reduces neuronal cell death and the number of microglial cells after excitotoxic damage PMID: 15932594
    8. rhIL-1ra may protect renal injury after asphyxia via inhibiting intrarenal inflammatory response. PMID: 16259926
    9. IL-1ra is a modulator of gender differences in the febrile response to lipopolysaccharides. PMID: 17138728
    10. physical training has an effect on IL-1beta, IL-6 and IL-1ra concentrations in various brain areas of the rat PMID: 18299269
    11. Estrogen-induced protection is associated with a decrease in IL-1beta and an increase in IL-1ra expression in the ischemic hippocampus which suggests that modulation of IL-1beta/IL-1ra might be a part of anti-inflammatory effects of estrogen. PMID: 18455872
    12. A pro-inflammatory orientation in the interleukin-1 beta/interleukin-1 receptor antagonist balance might play a role in the initiation of perinatal brain damages. PMID: 18511291

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    IL-1 family
  • 數據庫鏈接：


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