在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat Insulin-like growth factor binding protein 2,IGFBP-2 ELISA kit

Rat Insulin-like growth factor binding protein 2,IGFBP-2 ELISA kit

  • 中文名稱：
    大鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒
  • 貨號：
    CSB-E07351r
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒（CSB-E07351r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGFBP2含量。IGFBP2（胰島素樣生長因子結合蛋白2）是一種高親和力結合蛋白，在中樞神經系統的IGF（胰島素樣生長因子）調節中發揮重要作用。研究發現，IGFBP2在膠質瘤的發生、發展及預后中具有重要作用，其通過IGF依賴/非依賴通路、β-catenin通路等多種信號通路參與調節膠質瘤細胞的增殖、侵襲、轉移及血管生成等生理過程。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于科研場景中探索IGFBP - 2在糖脂代謝調控、生長發育異?；蚰[瘤微環境中的作用機制，為研究IGF信號通路及相關疾病模型提供靈敏可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Igfbp2 ELISA Kit; Igfbp-2Insulin-like growth factor-binding protein 2 ELISA Kit; IBP-2 ELISA Kit; IGF-binding protein 2 ELISA Kit; IGFBP-2 ELISA Kit; BRL-BP ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IGFBP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:20 Average % 107
    Range % 95-111
    1:40 Average % 104
    Range % 95-108
    1:80 Average % 90
    Range % 83-94
    1:160 Average % 97
    Range % 87-103
  • 回收率：
    The recovery of rat IGFBP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 90 82-94
    EDTA plasma (n=4) 101 90-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    40 2.631 2.568 2.600 2.439
    20 2.014 1.964 1.989 1.828
    10 1.126 1.083 1.105 0.944
    5 0.589 0.567 0.578 0.417
    2.5 0.347 0.356 0.352 0.191
    1.25 0.266 0.277 0.272 0.111
    0.625 0.219 0.212 0.216 0.055
    0 0.159 0.163 0.161 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻：
    1. Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. PMID: 24352370
    2. Abnormal expression of IGFBP-2 correlates with hyperoxia-induced lung injury in neonatal rats. PMID: 18549709
    3. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. PMID: 11914028
    4. results show that liver growth and cell proliferation in association with insulin-like growth factor-I and insulin-like growth factor binding proteins 1 and 2 levels are affected in utero by fetal undernutrition PMID: 12902319
    5. In proliferating astrocytes, IGFBP-2 may help target insulin-like growth factors (IGFs) to IGF-1 receptors, and IGFBP-2 proteases may play a role in enhancing the availability of IGFs. PMID: 15248291
    6. cathepsin L created a 14-kDa carboxyl IGFBP-2 fragment that corresponded to the sole antigen detected in IEC-18 cell lysates as well as a 16.5-kDa fragment found in the media PMID: 15705658
    7. retinoic acid modulates the secreted IGFBP-2 and -3 during O(2) exposure and inhibits the increase in collagen that occurs during lung injury PMID: 16055936
    8. Growth inhibition, which was supported by the strong induction of p21CIP1/WAF1, was correlated with increased secretion of IGFBP-2 and, unexpectedly, with its increased localization in the nucleus and particularly in the cytoplasm. PMID: 16131350
    9. IGFBP-2 plays a role in the lamellar bone formation process. PMID: 17308996
    10. In conclusion, MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of PMID: 18563800
    11. A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus. PMID: 18946176

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.
  • 數據庫鏈接：

    KEGG: rno:25662

    STRING: 10116.ENSRNOP00000023068

    UniGene: Rn.6813



主站蜘蛛池模板： 永久免费观看国产裸体美女| 日韩免费无码人妻波多野| 成人免费无码不卡毛片视频| 怡红院一区二区三区在线| 激情 小说 亚洲 图片 伦 | 综合网日日天干夜夜久久| 国产亚洲精品久久久ai换| 国产自偷在线拍精品热| 欧美丰满熟妇多毛xxxxx| 精品亚洲麻豆1区2区3区| 一本色道无码道dvd在线观看| 肉大捧一进一出免费视频| 国产一区二区三区在线视頻| 久久天堂av综合合色| 波多野结衣在线观看一码 | 久久精品道一区二区三区| 中文字幕乱码免费| 日本乱子人伦在线视频| 亚洲午夜无码极品久久| 一边摸一边叫床一边爽av| 国产综合内射日韩久| 欧美老肥妇做爰bbww| 亚洲制服 视频在线观看| 国产精品久久自在自线不| 亚洲成av人片香蕉片| 色综合天天综合网中文| 无码日韩人妻av一区免费| 天天摸天天做天天爽水多| 无码人中文字幕| 一道精品视频一区二区三区| 国产成人久久av免费| 久久久久久免费毛片精品| 午夜精品电影你懂的| 国产裸体歌舞一区二区| 久久人人爽人人爽人人片av东京热| 国产老熟女网站| 亚洲色老汉av无码专区最| 亚洲午夜精品久久久久久浪潮 | 国产清纯在线一区二区www| 午夜亚洲国产理论片二级港台二级 | 国产亚洲婷婷香蕉久久精品|