在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat Insulin-like growth factor binding protein 2,IGFBP-2 ELISA kit

Rat Insulin-like growth factor binding protein 2,IGFBP-2 ELISA kit

  • 中文名稱：
    大鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒
  • 貨號：
    CSB-E07351r
  • 規格：
    96T/48T
  • 價格：
    ￥3200/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠胰島素樣生長因子結合蛋白2(IGFBP-2)酶聯免疫試劑盒（CSB-E07351r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的IGFBP2含量。IGFBP2（胰島素樣生長因子結合蛋白2）是一種高親和力結合蛋白，在中樞神經系統的IGF（胰島素樣生長因子）調節中發揮重要作用。研究發現，IGFBP2在膠質瘤的發生、發展及預后中具有重要作用，其通過IGF依賴/非依賴通路、β-catenin通路等多種信號通路參與調節膠質瘤細胞的增殖、侵襲、轉移及血管生成等生理過程。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于科研場景中探索IGFBP - 2在糖脂代謝調控、生長發育異?；蚰[瘤微環境中的作用機制，為研究IGF信號通路及相關疾病模型提供靈敏可靠的檢測工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Igfbp2 ELISA Kit; Igfbp-2Insulin-like growth factor-binding protein 2 ELISA Kit; IBP-2 ELISA Kit; IGF-binding protein 2 ELISA Kit; IGFBP-2 ELISA Kit; BRL-BP ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Signal Transduction
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat IGFBP-2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:20 Average % 107
    Range % 95-111
    1:40 Average % 104
    Range % 95-108
    1:80 Average % 90
    Range % 83-94
    1:160 Average % 97
    Range % 87-103
  • 回收率：
    The recovery of rat IGFBP-2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 90 82-94
    EDTA plasma (n=4) 101 90-105
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    40 2.631 2.568 2.600 2.439
    20 2.014 1.964 1.989 1.828
    10 1.126 1.083 1.105 0.944
    5 0.589 0.567 0.578 0.417
    2.5 0.347 0.356 0.352 0.191
    1.25 0.266 0.277 0.272 0.111
    0.625 0.219 0.212 0.216 0.055
    0 0.159 0.163 0.161 　
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 基因功能參考文獻：
    1. Insulin-like growth factor 2 (IGF2) is an important regulator of fetal growth. PMID: 24352370
    2. Abnormal expression of IGFBP-2 correlates with hyperoxia-induced lung injury in neonatal rats. PMID: 18549709
    3. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. PMID: 11914028
    4. results show that liver growth and cell proliferation in association with insulin-like growth factor-I and insulin-like growth factor binding proteins 1 and 2 levels are affected in utero by fetal undernutrition PMID: 12902319
    5. In proliferating astrocytes, IGFBP-2 may help target insulin-like growth factors (IGFs) to IGF-1 receptors, and IGFBP-2 proteases may play a role in enhancing the availability of IGFs. PMID: 15248291
    6. cathepsin L created a 14-kDa carboxyl IGFBP-2 fragment that corresponded to the sole antigen detected in IEC-18 cell lysates as well as a 16.5-kDa fragment found in the media PMID: 15705658
    7. retinoic acid modulates the secreted IGFBP-2 and -3 during O(2) exposure and inhibits the increase in collagen that occurs during lung injury PMID: 16055936
    8. Growth inhibition, which was supported by the strong induction of p21CIP1/WAF1, was correlated with increased secretion of IGFBP-2 and, unexpectedly, with its increased localization in the nucleus and particularly in the cytoplasm. PMID: 16131350
    9. IGFBP-2 plays a role in the lamellar bone formation process. PMID: 17308996
    10. In conclusion, MMP-9-induced IGFBP2 proteolysis may be regarded as an important post-translational event involved in astrocytoma aggressiveness. These new findings support drug targeting of MMP-9 as an interesting approach in the treatment of PMID: 18563800
    11. A brain region- and cell type-specific responses to estrogen in rat brain, suggesting that Igf signaling may mediate the estrogen function in the hippocampus. PMID: 18946176

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.
  • 數據庫鏈接：

    KEGG: rno:25662

    STRING: 10116.ENSRNOP00000023068

    UniGene: Rn.6813



主站蜘蛛池模板： 中文字幕在线观看| 豆国产95在线 | 亚洲| 亚洲愉拍99热成人精品| 亚欧无线一线二线三线区别| 免费国产成人高清在线观看网站| 国产欧美国日产高清| 亚洲精品nv久久久久久久久久 | 免费人妻精品一区二区三区| 亚洲综合色噜噜狠狠网站超清| 超清精品丝袜国产自在线拍| 青青草免费公开视频| 国产精品久久国产三级国| 亚洲日本va午夜中文字幕久久| 国产98在线 | 免费| 免费人成无码大片在线观看| 欧美性xxxx极品少妇| 久久亚洲精品中文字幕一区| 伊人久久大香线蕉无码不卡| ass日本丰满熟妇pics| 色与欲影视天天看综合网| 国产在线播放精品视频| 色久悠悠婷婷综合在线亚洲| 中文字幕色av一区二区三区| 特级a做爰全过程片| 亚洲线精品一区二区三八戒| 国产成人精品电影在线观看| 99久久国产综合精品swag| 久久精品aⅴ无码中文字字幕不卡| 99精品视频免费热播在线观看| 老鲁夜夜老鲁| 日产精品高潮呻吟av久久| 国产精品久久久久电影网| 99久久人妻无码精品系列蜜桃| 国产精品久久久久久亚洲毛片 | 女人爽到高潮视频免费直播| 乱中年女人伦av三区| 一本色道无码道dvd在线观看| 欧美亚洲色aⅴ大片| 人人爽人人爽人人爽| 国产成人无码综合亚洲日韩| 人妻出轨av中文字幕|