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  4. Rat Fibronectin type III domain-containing protein 5(FNDC5) ELISA kit

Rat Fibronectin type III domain-containing protein 5(FNDC5) ELISA kit

  • 中文名稱：
    大鼠纖維連接蛋白Ⅲ型結(jié)構(gòu)域蛋白5(FNDC5)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL008770RA
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠纖維連接蛋白Ⅲ型結(jié)構(gòu)域蛋白5(FNDC5)酶聯(lián)免疫試劑盒（CSB-EL008770RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的FNDC5含量。FNDC5即纖維連接蛋白結(jié)構(gòu)域蛋白5，是一種跨膜蛋白。其剪切產(chǎn)物鳶尾素具多種生理功能。研究機(jī)制方面，它參與能量代謝調(diào)節(jié)，能增加脂肪氧化和能量消耗，還對骨骼、肌肉等組織的生長和修復(fù)有影響，在代謝疾病防治等領(lǐng)域受關(guān)注。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL，適用于科研領(lǐng)域?qū)NDC5表達(dá)水平的分析；尤其適用于探究運(yùn)動干預(yù)、代謝調(diào)控機(jī)制、肌肉生理學(xué)及神經(jīng)退行性疾病模型中的FNDC5動態(tài)變化；為代謝研究、運(yùn)動生理學(xué)及分子機(jī)制探索提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Fndc5Fibronectin type III domain-containing protein 5 [Cleaved into: Irisin] ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.625 ng/mL-40 ng/mL
  • 靈敏度：
    0.156 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Metabolism
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%      
    Three samples of known concentration were tested twenty times on one plate to assess.  
    Inter-assay Precision (Precision between assays): CV%<10%      
    Three samples of known concentration were tested in twenty assays to assess.    
                 
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat FNDC5 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)  
    1:1 Average % 84  
    Range % 80-88  
    1:2 Average % 102  
    Range % 98-109  
    1:4 Average % 93  
    Range % 89-97  
    1:8 Average % 90  
    Range % 86-98  
  • 回收率：
    The recovery of rat FNDC5 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range  
    Serum (n=5) 95 90-99  
    EDTA plasma (n=4) 89 84-95  
                 
                 
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected  
    40 2.548 2.452 2.500 2.308  
    20 1.876 1.931 1.904 1.712  
    10 1.251 1.314 1.283 1.091  
    5 0.780 0.792 0.786 0.594  
    2.5 0.497 0.483 0.490 0.298  
    1.25 0.402 0.385 0.394 0.202  
    0.625 0.273 0.279 0.276 0.084  
    0 0.195 0.188 0.192    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA.
  • 基因功能參考文獻(xiàn)：
    1. The results of the study suggest that irisin values increase in thyroid dysfunction, hypo- and hyperthyroidism, and that when hypothyroidism is corrected by thyroxin administration and hyperthyroidism by PTU injection, plasma irisin values go back to normal. PMID: 29182513
    2. e suggested that levels of circulating irisin are the result of the sum of the irisin produced by different depots of adipose tissue and skeletal muscle. This study shows for the first time that there are differences in FNDC5 expression depending on white adipose tissue depots. PMID: 27432282
    3. The secretion of FNDC5 from myotubes and beta-cells in response to exogenous fatty acids, the effects of recombinant FNDC5 on insulin biosynthesis and glucose-stimulated insulin secretion, and beta-cell apoptosis are reported. PMID: 28724742
    4. results firstly revealed that irisin mitigated oxygen-glucose deprivation-induced neuronal injury in part via inhibiting ROS-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke. PMID: 28961497
    5. Irisin could affects the nutrition behavior and energy metabolism. PMID: 28242329
    6. Study demonstrated that irisin promotes beta cell proliferation through the ERK and p38 MAPK signaling pathways. Irisin can also inhibit the high-glucose-induced apoptosis of INS-1 cells and improve the function of pancreatic beta cells. Findings suggest that irisin may have applications in the prevention and treatment of type 2 diabetes mellitus because of its protective effect on the secretion of pancreatic beta cells. PMID: 28394923
    7. Swimming exercise increases serum Fndc5 level. PMID: 27177924
    8. the expression of FNDC5 in the stomach of rats and its regulation by body composition, suggesting a potential role of gastric FNDC5 in energy homeostasis. PMID: 26961074
    9. the irisin affects the expression of the UCPs in a central way. PMID: 26926562
    10. Methylprednisolone and carnosine and the combination of the two, significantly increased irisin in plasma and were accompanied by a significant rise in irisin immunoreactivity of brain and spinal cord tissues of the injured rats PMID: 26142757
    11. studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities. PMID: 25820670
    12. the fat-burning protein irisin locally produced in peripheral and central tissues could act as a gatekeeper of metabolic energy regulation in those tissues PMID: 25261800
    13. changes in irisin mRNA and protein levels in rat muscle after acute exercise are limited and depend on training status and the muscle type; irisin serum levels remained stable after acute exercise or endurance training PMID: 24930518
    14. Irisin increases near myocardial connective tissue, with production in skeletal muscle, liver and kidney after myocardial infarction. PMID: 24576483
    15. High supernatant irisin could come from connective tissues around skeletal muscle, especially nerve sheaths located within it. Skeletal muscle is probably not a main irisin source. PMID: 24345335
    16. This immunohistochemical results demonstrate the expression of irisin immunoreactivity in three types of cells: skeletal, cardiac muscle, and Purkinje cells of the cerebellum. PMID: 23470775
    17. Further research is needed to examine whether other adipose tissue-derived factors up-regulate FNDC5 transcription and/or inhibit irisin biosynthesis from FNDC5 PMID: 23498898
    18. In addition to skeletal muscles, white adipose tissue also secretes FNDC5; hence, it may behave as an adipokine as well as a myokine. PMID: 23593248

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Peroxisome membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫鏈接：


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