在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Rat Cathepsin K,cath-K ELISA Kit

Rat Cathepsin K,cath-K ELISA Kit

  • 中文名稱：
    大鼠組織蛋白酶K(cath-K)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09439r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠組織蛋白酶K(cath-K)酶聯(lián)免疫試劑盒（CSB-E09439r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CTSK含量。CTSK（組織蛋白酶K）是一種在骨重塑過程中起關(guān)鍵作用的酶，主要在破骨細(xì)胞中表達(dá)。其研究機(jī)制涉及降解骨細(xì)胞外基質(zhì)，促進(jìn)骨吸收。CTSK在多種癌癥中表達(dá)，可能促進(jìn)腫瘤細(xì)胞增殖、侵襲和遷移。研究CTSK有助于開發(fā)新的治療策略。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL，適用于大鼠骨代謝研究、骨骼疾病動(dòng)物模型評(píng)估及骨靶向藥物作用機(jī)制探索等科研領(lǐng)域，可為骨生物學(xué)、病理機(jī)制研究及藥物開發(fā)提供穩(wěn)定可靠的定量分析支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ctsk ELISA Kit; Cathepsin K ELISA Kit; EC 3.4.22.38 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat cath-K in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 104    
    Range % 100-107    
    1:2 Average % 99    
    Range % 95-103    
    1:4 Average % 85    
    Range % 80-90    
    1:8 Average % 107    
    Range % 103-110    
  • 回收率：
    The recovery of rat cath-K spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 86 83-89    
    EDTA plasma (n=4) 95 90-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    1000 2.801 2.765 2.783 2.682    
    500 2.342 2.204 2.273 2.172    
    250 1.343 1.406 1.375 1.274    
    125 0.679 0.701 0.690 0.589    
    62.5 0.399 0.405 0.402 0.301    
    31.2 0.251 0.242 0.247 0.146    
    15.6 0.166 0.164 0.165 0.064    
    0 0.102 0.100 0.101 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
  • 基因功能參考文獻(xiàn)：
    1. the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin PMID: 29207029
    2. cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies PMID: 14585819
    3. In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance. PMID: 17181996
    4. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. PMID: 18664521
    5. The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined. PMID: 18974601

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.
  • 蛋白家族：
    Peptidase C1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:29175

    STRING: 10116.ENSRNOP00000028730

    UniGene: Rn.5598



主站蜘蛛池模板： 越南女子杂交内射bbwxz| 色欲av巨乳无码一区二区| 亚洲中文字幕无码中文| 欧美丰满美乳xxⅹ高潮www| 国产办公室秘书无码精品99| 波多野结衣人妻| 香蕉av福利精品导航| 午夜福利无遮挡十八禁视频| 牛和人交videos欧美| 亚洲v欧美v国产v在线观看| 人妻妺妺窝人体色www聚色窝| 国内无遮挡18禁无码网站免费| 亚洲欧洲日产国码无码| 无套内谢孕妇毛片免费看| 柠檬福利精品视频导航| 欧美亚洲色aⅴ大片| 亚洲国产福利一区二区三区| 草草影院发布页| 曰韩欧美群交p片内射| 高潮射精日本韩国在线播放| 国产特级毛片aaaaaa高清| 永久免费无码日韩视频| 色老99久久九九爱精品| 女人国产香蕉久久精品| 波多野结衣在线观看一码| 国色天香天天影院综合网| 国产美女裸身网站免费观看视频| 久久精品久久久久观看99水蜜桃| 久久综合88熟人妻| 国产成人精品永久免费视频| 亚洲中文字幕aⅴ天堂| 欧美黑人又大又粗xxxxx| 亚洲欧美日韩国产综合在线一区 | 亚洲国产欧美在线观看| 国产亚洲情侣一区二区无| 国产丰满麻豆vⅰde0sex| 亚洲国产精久久久久久久| 日韩人妻熟女中文字幕a美景之屋 高h纯肉无码视频在线观看 | 下面一进一出好爽视频| 亚洲综合在线另类色区奇米| 粉嫩小泬视频无码视频软件|