在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 試劑盒
  3. 酶聯(lián)免疫試劑盒
  4. Rat Cathepsin K,cath-K ELISA Kit

Rat Cathepsin K,cath-K ELISA Kit

  • 中文名稱：
    大鼠組織蛋白酶K(cath-K)酶聯(lián)免疫試劑盒
  • 貨號(hào)：
    CSB-E09439r
  • 規(guī)格：
    96T/48T
  • 價(jià)格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠組織蛋白酶K(cath-K)酶聯(lián)免疫試劑盒（CSB-E09439r）為雙抗夾心法ELISA試劑盒，定量檢測(cè)血清、血漿、組織勻漿樣本中的CTSK含量。CTSK（組織蛋白酶K）是一種在骨重塑過程中起關(guān)鍵作用的酶，主要在破骨細(xì)胞中表達(dá)。其研究機(jī)制涉及降解骨細(xì)胞外基質(zhì)，促進(jìn)骨吸收。CTSK在多種癌癥中表達(dá)，可能促進(jìn)腫瘤細(xì)胞增殖、侵襲和遷移。研究CTSK有助于開發(fā)新的治療策略。試劑盒檢測(cè)范圍為15.6 pg/mL-1000 pg/mL，適用于大鼠骨代謝研究、骨骼疾病動(dòng)物模型評(píng)估及骨靶向藥物作用機(jī)制探索等科研領(lǐng)域，可為骨生物學(xué)、病理機(jī)制研究及藥物開發(fā)提供穩(wěn)定可靠的定量分析支持。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Ctsk ELISA Kit; Cathepsin K ELISA Kit; EC 3.4.22.38 ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測(cè)范圍：
    15.6 pg/mL-1000 pg/mL
  • 靈敏度：
    3.9 pg/mL
  • 反應(yīng)時(shí)間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測(cè)波長(zhǎng)：
    450 nm
  • 研究領(lǐng)域：
    Signal Transduction
  • 測(cè)定原理：
    quantitative
  • 測(cè)定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%        
    Three samples of known concentration were tested twenty times on one plate to assess.    
    Inter-assay Precision (Precision between assays): CV%<10%        
    Three samples of known concentration were tested in twenty assays to assess.      
                   
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat cath-K in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
    　 Sample Serum(n=4)    
    1:1 Average % 104    
    Range % 100-107    
    1:2 Average % 99    
    Range % 95-103    
    1:4 Average % 85    
    Range % 80-90    
    1:8 Average % 107    
    Range % 103-110    
  • 回收率：
    The recovery of rat cath-K spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
     
    Sample Type Average % Recovery Range    
    Serum (n=5) 86 83-89    
    EDTA plasma (n=4) 95 90-100    
                   
                   
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
     
    pg/ml OD1 OD2 Average Corrected    
    1000 2.801 2.765 2.783 2.682    
    500 2.342 2.204 2.273 2.172    
    250 1.343 1.406 1.375 1.274    
    125 0.679 0.701 0.690 0.589    
    62.5 0.399 0.405 0.402 0.301    
    31.2 0.251 0.242 0.247 0.146    
    15.6 0.166 0.164 0.165 0.064    
    0 0.102 0.100 0.101 　    
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
  • 基因功能參考文獻(xiàn)：
    1. the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin PMID: 29207029
    2. cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies PMID: 14585819
    3. In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance. PMID: 17181996
    4. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. PMID: 18664521
    5. The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined. PMID: 18974601

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.
  • 蛋白家族：
    Peptidase C1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: rno:29175

    STRING: 10116.ENSRNOP00000028730

    UniGene: Rn.5598



主站蜘蛛池模板： 永久免费的av在线电影网无码 | 日产精品一区二区| 最近免费中文字幕中文高清百度| 国产无套粉嫩白浆在线| 一区二区精品视频日本| 一本一道色欲综合网| 久久精品aⅴ无码中文字字幕| 亚洲小说春色综合另类| 国产福利一区二区三区在线观看| 婷婷六月丁香缴 清| 无套内射chinesehd熟女| 无码av永久免费专区麻豆| 中文天堂国产最新| 三上悠亚精品一区二区久久| 日韩高清成片免费视频| 欧美日韩中文在线字幕视频| 成人国产亚洲精品a区天堂| 久久国产劲暴∨内射新川| 看成年全黄大色黄大片| 亚洲自偷自偷偷色无码中文| 久久久精品日本一区二区三区| 成在人线av无码免观看午夜网| 国产制服丝袜亚洲高清| 精品一卡2卡3卡4卡新区在线| 好吊妞人成视频在线观看27du| 未满小14洗澡无码视频网站| 大肉大捧一进一出好爽app| 久久免费视频精品在线| 亚洲成a人片在线观看中文无码| 久久精品99国产国产精| av中文字幕潮喷人妻系列| 日日橹狠狠爱欧美视频| 欧美在线观看免费专区| 再深点灬舒服灬太大了网站| 特级无码毛片免费视频尤物| 色一乱一伦一图一区二区精品| 人成午夜免费视频无码| 亚洲精品久久无码av片| 国产成人一区二区精品视频| 国产精品欧美成人| 国产精品va无码一区二区|