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  4. Rat Angiopoietin 1,ANG-1 ELISA Kit

Rat Angiopoietin 1,ANG-1 ELISA Kit

  • 中文名稱：
    大鼠血管生成素1(ANG-1)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-E07303r
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3900/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    大鼠血管生成素1(ANG-1)酶聯(lián)免疫試劑盒（CSB-E07303r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的ANGPT1含量。ANGPT1即血管生成素1，為血管生成素家族成員，在血管生成、維持血管穩(wěn)定和調(diào)節(jié)內(nèi)皮細(xì)胞功能等方面起重要作用。其研究機(jī)制主要圍繞與受體Tie-2結(jié)合，激活下游信號通路，促進(jìn)內(nèi)皮細(xì)胞存活、遷移和血管成熟。相關(guān)研究有助于探索血管相關(guān)疾病治療策略。試劑盒檢測范圍為6.25 ng/mL-400 ng/mL，適用于研究血管生成相關(guān)疾病模型（如缺血再灌注損傷、腫瘤血管化）中ANG - 1的動態(tài)變化，或探索其與血管內(nèi)皮生長因子（VEGF）等分子的協(xié)同調(diào)控機(jī)制，為心血管生物學(xué)、腫瘤微環(huán)境及再生醫(yī)學(xué)等科研領(lǐng)域提供靈敏、特異的檢測工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    Angpt1Angiopoietin-1 ELISA kit; ANG-1 ELISA kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    6.25 ng/mL-400 ng/mL
  • 靈敏度：
    1.56 ng/mL
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cardiovascular
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of rat ANG-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    　 Sample Serum(n=4)
    1:1 Average % 104
    Range % 93-109
    1:2 Average % 112
    Range % 103-116
    1:4 Average % 94
    Range % 84-98
    1:8 Average % 90
    Range % 83-94
  • 回收率：
    The recovery of rat ANG-1 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 90 83-94
    EDTA plasma (n=4) 103 92-108
  • 標(biāo)準(zhǔn)曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/ml OD1 OD2 Average Corrected
    400 2.985 2.845 2.915 2.781
    200 2.681 2.579 2.630 2.496
    100 2.297 2.213 2.255 2.121
    50 1.684 1.622 1.653 1.519
    25 1.001 0.956 0.979 0.845
    12.5 0.449 0.441 0.445 0.311
    6.25 0.251 0.242 0.247 0.113
    0 0.132 0.136 0.134 　
  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of Ang-1 enhanced the tube formation, migration, and proliferation ability of endothelial progenitor cells. EPC transplantation facilitated occlusion of carotid aneurysms. PMID: 29197611
    2. The study showed for the first time that ANG-1 plays a vital role in the early rather than late phase of adjuvant-induced arthritis pathogenesis making it an attractive non-invasive tool for early diagnosis and prediction of disease prognosis PMID: 24664592
    3. Ang-1-EPC improved cell survival during inflammation. PMID: 24606182
    4. Ang1 was implicated in ASC-induced suppression of neointimal formation. PMID: 23486192
    5. Endothelin-1 regulates ANG-1 production and vascular endothelial growth factor (VEGF)A in proliferating astrocytes. PMID: 22927341
    6. responsible for the vascular hyperreactivity at early hemorrhagic shock through the Tie2-Akt-eNOS pathway PMID: 22869617
    7. The expression of Ang-1 mRNA and TSP-1 in renal tissue of rats after subtotal nephrectomy was significantly up-regulated. PMID: 19821086
    8. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation PMID: 22843181
    9. Prolonged exposure of high concentration of oxygen may cause impairment of lung vascular development by inhibiting expression of Ang-1 in neonatal rats. PMID: 22336306
    10. The change of Ang-1, which is early upregulation and late downregulation, exists in diabetic renal tissue. PMID: 17294737
    11. Wenyang Huoxue Recipe can up-regulate the expression of Ang-l mRNA rats with chronic aristolochic acid nephropathy. PMID: 18471417
    12. Expression of angiopoietin-1 and the angiopoietin receptor dropped markedly after stroke in SHR stroke-prone rats, but was not different after ischemia in SHR and WKY rat strains PMID: 11822892
    13. ang 1 stabilizes testicular microvessels under basal conditions and that a shift in this balance caused by increased ang 2, together with increased VEGF-A, allows vascular leakage, high endothelial cell proliferation PMID: 12773423
    14. Rats engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop severe pulmonary hypertension. PMID: 14512515
    15. Overexpression of angiopoietin-1 using an adeno-associated virus vector causes pulmonary hypertension in rats. These data provide a novel physiologic animal model for pulmonary hypertension. PMID: 14759414
    16. E2 increases Ang-1 and enhances capillary density in brain under basal conditions through estrogen receptor-alpha, priming the middle cerebral artery territory for survival after experimental focal ischemia PMID: 15637314
    17. Ang-1 promotes neurite outgrowth from dorsal root ganglia cells positive for Tie2. PMID: 15714275
    18. It is concluded that adipocyte-secreted Ang-1 supports neurite outgrowth, which is involved in synaptogenesis. The novel function of Ang-1 appears to play a physiological role in WAT plasticity. PMID: 16493688
    19. Ang1 protects cardiomyocytes from oxidative stress-induced apoptosis by regulating the activity of Proto-Oncogene Proteins c-akt PMID: 17559808
    20. ANGPT1 is necessary for follicular development induced by gonadotropins. PMID: 17989359
    21. Expression of angiopoietin-1 significantly decreased in the pulmonary arteries in chronic hypoxic pulmonary hypertension. PMID: 18073453
    22. Abnormal expression and reciprocal egulation of Angpt1 may play important roles in the development of chronic allograft nephropathy in rat renal allografts. PMID: 18929864
    23. Ang1 modifies basal microvessel permeability coefficients, in keeping with previous reports demonstrating reduced solute flux in inflamed vessels. PMID: 19297368
    24. Ang1 induces neurite outgrowth in PC12 cells in a Tie2-independent, beta1-integrin-FAK-PI3K-Akt-dependent manner. NGF and Ang1 mediate neurite outgrowth via two independent signaling mechanisms. PMID: 19379779
    25. Vascular endothelial growth factor and angiopoietin-1 are involved in liver regeneration following partial hepatectomy. PMID: 11549276

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  • 亞細(xì)胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：


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