在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

Rat Advanced glycosylation end product-specific receptor(AGER) ELISA kit

  • 中文名稱：
    大鼠晚期糖基化終產物特異性受體(AGER)酶聯免疫試劑盒
  • 貨號：
    CSB-EL001441RA
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠晚期糖基化終產物特異性受體(AGER)酶聯免疫試劑盒（CSB-EL001441RA）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿,組織勻漿樣本中的AGER含量。AGER即晚期糖基化終末產物受體，在炎癥、氧化應激等病理過程發揮重要作用。研究顯示，它可與多種配體結合，激活下游信號通路，引發細胞內一系列反應，參與糖尿病并發癥、神經退行性疾病、腫瘤等疾病發生發展，是潛在治療靶點。試劑盒檢測范圍為31.25 pg/mL-2000 pg/mL，靈敏度為7.81 pg/mL。該產品主要應用于基礎研究領域，如糖尿病相關器官損傷的分子機制探索、神經炎癥模型的蛋白表達分析，或藥物干預下AGER信號通路變化的體外評估，為科研人員提供可靠的實驗工具。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Ager ELISA Kit; Rage ELISA Kit; Advanced glycosylation end product-specific receptor ELISA Kit; Receptor for advanced glycosylation end products ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma,tissue homogenates
  • 檢測范圍：
    31.25 pg/mL-2000 pg/mL
  • 靈敏度：
    7.81 pg/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

    　

    Intra-Assay Precision

    Inter-Assay Precision

    Sample

    1

    2

    3

    1

    2

    3

    n

    20

    20

    20

    20

    20

    20

    Mean(pg/ml)

    224.423

    224.423

    225.339

    224.377

    225.431

    224.881

    SD

    0.034

    0.030

    0.031

    0.040

    0.037

    0.039

    CV(%)

    4.433

    3.911

    4.031

    5.216

    4.810

    5.078

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of rat AGER in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    92

    Range %

    90-94

    1:2

    Average %

    96

    Range %

    90-102

    1:4

    Average %

    102

    Range %

    99-105

    1:8

    Average %

    87

    Range %

    80-94

  • 回收率：

    The recovery of rat AGER spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    90

    87-95

    EDTA plasma (n=4)

    101

    97-106

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    pg/ml

    OD1

    OD2

    Average

    Corrected

    2000

    2.703

    2.878

    2.791

    2.615

    1000

    1.903

    1.856

    1.880

    1.704

    500

    1.245

    1.154

    1.200

    1.024

    250

    0.731

    0.747

    0.739

    0.563

    125

    0.556

    0.533

    0.545

    0.369

    62.5

    0.402

    0.392

    0.397

    0.221

    31.25

    0.272

    0.275

    0.274

    0.098

    0

    0.173

    0.179

    0.176

    　

  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 最新研究進展：
        最新研究發現，AGER基因的多態性可能與各種疾病的發生有關，包括糖尿病、肺炎、慢性阻塞性肺病等。此外，AGER的表達也與肺癌、乳腺癌、胃癌等腫瘤的發生和發展有關。
     
  • 功能：
    Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Endothelial cells and cardiomyocytes.
  • 數據庫鏈接：


主站蜘蛛池模板： 中文字幕无码无码专区| 无码丰满熟妇| 亚洲日本一区二区一本一道| 日韩久久无码免费毛片软件| 亚洲中文字幕在线第二页| 好了av四色综合无码久久| 午夜福利18以下勿进免费| 日韩做a爰片久久毛片a片| 国产乱码二卡3卡四卡| 极品少妇的粉嫩小泬视频| 亚洲国产无线乱码在线观看| 国内大量揄拍人妻精品視頻| 果冻传媒2021精品一区| 国产剧情无码播放在线观看| 无码专区久久综合久中文字幕| 92国产精品午夜福利| 国产伦子沙发午休系列资源曝光| 久久婷婷五月综合色欧美蜜芽 | 动漫精品专区一区二区三区| 精品无码久久久久国产app| 国产亚洲精品精品国产亚洲综合| 99热这里有精品| 国产97公开成人免费视频在线观看| 天天爽天天狠久久久综合麻豆| 一道久在线无码加勒比| 久久超乳爆乳中文字幕| 国产精品美女www爽爽爽视频| 中文av岛国无码免费播放| 一級特黃色毛片免費看| 亚洲熟妇自偷自拍另类| 看曰本女人大战黑人视频| 国产成人啪精品视频网站| 日日摸日日碰夜夜爽无| 50岁熟妇大白屁股真爽| 小sao货水好多真紧h无码视频 | 国产午夜福利小视频合集| 国产熟女内射oooo| 中国大陆高清aⅴ毛片| 激情射精爆插热吻无码视频| 美女又大又黄www免费网站| 亚洲色无码中文字幕yy51999|